Protein Alignment CG10445 and MOT1

DIOPT Version :10

• Sequence 1: NP_649751.2
• Gene: CG10445 / 40938
• FlyBaseID: FBgn0037531
• Length: 945
• Species: Drosophila melanogaster
• Sequence 2: NP_015243.1
• Gene: MOT1 / 856023
• SGDID: S000006003
• Length: 1867
• Species: Saccharomyces cerevisiae
• Alignment Length: 974
• Identity: 212/974 - (21%)
• Similarity: 381/974 - (39%)
• Gaps: 287/974 - (29%)

  Fly    13 HKQSCSIQDQSSVPVPDSSGEINNWMEPEPVDSLELSGEYA----------DNESAIFVSASEYN 67
            ::::..:.::....:.||.|.:.. :.|...|||..|..:.          .|.|....||:...
Yeast  1073 NEEASKVDNEQGQKIVDSFGVLRA-LFPFMSDSLRSSEVFTRFPVLLTFLRSNLSVFRYSAARTF 1136

  Fly    68 EKKAQIDQL------VQKILTMEQQQRQLEENASETKELCDLKLHLEK------LNARLEALGEF 120
            ...|:|..:      :::||.:......|.:....|:.:..|.|.:|.      :...:..||..
Yeast  1137 ADLAKISSVEVMAYTIREILPLMNSAGSLSDRQGSTELIYHLSLSMETDVLPYVIFLIVPLLGRM 1201

  Fly   121 LDTLRLREDQQEIKIEDNSELVDHTEQPKWSNLYSGL------------NRYRQKANHTAAQFYQ 173
            .|:   .||.:.:.....:.::      |...|.:|:            :|.|::
Yeast  1202 SDS---NEDVRNLATTTFASII------KLVPLEAGIADPKGLPEELVASRERER---------- 1247

  Fly   174 HKSNIIDSLKTLYEPIQPRPAIDDLEKQPALLLVRLLKHQQSCLKWMQFRERQKISGGILADDMG 238
                  |.::.:.:|.:.:|.     |.|..:...|.|:||..:.|:.|..:..:. |||.||||
Yeast  1248 ------DFIQQMMDPSKAKPF-----KLPIAIKATLRKYQQDGVNWLAFLNKYHLH-GILCDDMG 1300

  Fly   239 LGKTLSMIALILASEETKNRKREEKKKALTLKWTQEFNRVYCKEIRKISMFDDEEESGKEEEQYE 303
            |||||..|. |:||::                           .:||              |.||
Yeast  1301 LGKTLQTIC-IIASDQ---------------------------YLRK--------------EDYE 1323

  Fly   304 PPEKRTCHVKTKKINQFRILDDDDNDAGDKAVVEDEQKDLLAKTPEPEVFSSDEEEEHLSNGRYP 368
                     ||:.:                     |.:.|                        |
Yeast  1324 ---------KTRSV---------------------ESRAL------------------------P 1334

  Fly   369 SANTLVVCPMSVMCQWAHEVASKVAQNA--IRVLTFHGPNRHEIGIE-AFRSYDLVITSYNLVVN 430
            |   |::||.|:...|.:|    ..|.|  ::|:.:.|.....:.:. .....|:::|||::..|
Yeast  1335 S---LIICPPSLTGHWENE----FDQYAPFLKVVVYAGGPTVRLTLRPQLSDADIIVTSYDVARN 1392

  Fly   431 ELKRYGNTSPLFAVYWNRVILDEAHIIRNSKTNCCNSVCQLRAHCHWALTGTPVQNRGVDVFALL 495
            :|.....|.      :|..:|||.|||:||::....:|.::.|:....|||||:||..:::::|.
Yeast  1393 DLAVLNKTE------YNYCVLDEGHIIKNSQSKLAKAVKEITANHRLILTGTPIQNNVLELWSLF 1451

  Fly   496 RFVNVPNFQDLQQWKKNLNESMLGHRRLNFIIKPLMLRR---TKQKLQASGDMPALPSLKIELIC 557
            .|: :|.|..        .|.|...|    ..||:...|   |..|.|.:|.: ||.:|..:::.
Yeast  1452 DFL-MPGFLG--------TEKMFQER----FAKPIAASRNSKTSSKEQEAGVL-ALEALHKQVLP 1502

  Fly   558 VQLSKTEMAVYQILSAISKKIFTQFLLQREKGNSDLNYYSLERTPQFIAGHMSDERYNEIYERFL 622
            ..|.:.:   ..:||.:..||...:..  |.|:.....| ::.|          ::...:.|:.:
Yeast  1503 FMLRRLK---EDVLSDLPPKIIQDYYC--ELGDLQKQLY-MDFT----------KKQKNVVEKDI 1551

  Fly   623 KSLGYNPGEKILGIYILVLLLRLRQFCCHPGLMIGMLRGALT-AED-VQNVKVDASDVEGQLKMD 685
            ::.....|::    :|...|..:|:.|.||.|::......|. .:| ::...:|..|:....|:.
Yeast  1552 ENSEIADGKQ----HIFQALQYMRKLCNHPALVLSPNHPQLAQVQDYLKQTGLDLHDIINAPKLS 1612

  Fly   686 VLAELDKFDETDSEDDCCDEEDSTRRDGNFKLEVIKDEIKEENVPWDSGDDLPTASSFEDQLDSA 750
            .|..| .|:....|:| .|::.|  :|.||.:         :||                 :...
Yeast  1613 ALRTL-LFECGIGEED-IDKKAS--QDQNFPI---------QNV-----------------ISQH 1647

  Fly   751 RALKLLNPQNPIFQFIRPSAKLKMVIDKLEELLTGTNDKIIVTSQWVSYLAIVRKRLQDLSWETL 815
            |||        ||      .:||.::|.:|      ||             :.:|.:..:::..|
Yeast  1648 RAL--------IF------CQLKDMLDMVE------ND-------------LFKKYMPSVTYMRL 1679

  Fly   816 DFNGQLTAKEREIVLRDFNANNEKRVLLLSLTAGGVGLNLNVANHMLIVDLHWNPQLERQAQDRI 880
            |  |.:..::|:.|:|.||.:.....|||:...||:||||..|:.::.|:..|||..:.||.||.
Yeast  1680 D--GSIDPRDRQKVVRKFNEDPSIDCLLLTTKVGGLGLNLTGADTVIFVEHDWNPMNDLQAMDRA 1742

  Fly   881 YRYGQTKPTFIYRYMCQDTVEQRIKSLQDCKLEIAKVVLPEEGGEVTKCVGGGLNLAELKKLFE 944
            :|.||.|...:||.:.:.|:|::|..||..|:.||..|:.::...:     ..::..:|..||:
Yeast  1743 HRIGQKKVVNVYRIITKGTLEEKIMGLQKFKMNIASTVVNQQNSGL-----ASMDTHQLLDLFD 1801

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10445	NP_649751.2	HepA	<113..919	CDD:440319	187/825 (23%)
		DEAD-like_helicase_N	209..534	CDD:475120	77/327 (24%)
MOT1	NP_015243.1	HEAT repeat	360..385	CDD:293787
		HEAT repeat	406..438	CDD:293787
		HEAT repeat	449..481	CDD:293787
		HEAT repeat	490..519	CDD:293787
		HEAT repeat	543..572	CDD:293787
		DUF3535	611..1063	CDD:463447
		HepA	<1258..1781	CDD:440319	175/736 (24%)