Protein Alignment CG10445 and ISW2

DIOPT Version :10

• Sequence 1: NP_649751.2
• Gene: CG10445 / 40938
• FlyBaseID: FBgn0037531
• Length: 945
• Species: Drosophila melanogaster
• Sequence 2: NP_014948.1
• Gene: ISW2 / 854480
• SGDID: S000005831
• Length: 1120
• Species: Saccharomyces cerevisiae
• Alignment Length: 981
• Identity: 187/981 - (19%)
• Similarity: 333/981 - (33%)
• Gaps: 379/981 - (38%)

  Fly     2 ESSSPSDTTEIHKQSCSIQDQSSVPVPDSSGEINNWMEPEPVDSLELSGEYADNESAIFVSASEY 66
            :|:..||...| .||..:.|:....|.|...|.  |.:.:....|::..:||..:.    .:..|
Yeast    31 KSNGSSDDDNI-GQSEELSDKEIYTVEDRPPEY--WAQRKKKFVLDVDPKYAKQKD----KSDTY 88

  Fly    67 NE----------------KKAQIDQLVQKILTMEQQQRQLEENASETKELCDLKLHLEKLNARLE 115
            ..                .||:.|:.:||:|      :||:.:|::..:.........:.:.:.|
Yeast    89 KRFKYLLGVTDLFRHFIGIKAKHDKNIQKLL------KQLDSDANKLSKSHSTVSSSSRHHRKTE 147

  Fly   116 ALGEFLDTLRLREDQQEIKIEDNSELVDHTEQPKWSNLYSGLNRYRQKANHTAAQFYQHKSNIID 180
                       :|:..|:..::..|:||               .|::..      |.....:.:.
Yeast   148 -----------KEEDAELMADEEEEIVD---------------TYQEDI------FVSESPSFVK 180

  Fly   181 SLKTLYEPIQPRPAIDDLEKQPALLLVRLLKHQQSCLKWMQFRERQKISGGILADDMGLGKTLSM 245
            |.|                         |..:|...|.|:......|:| |||||:|||||||..
Yeast   181 SGK-------------------------LRDYQVQGLNWLISLHENKLS-GILADEMGLGKTLQT 219

  Fly   246 IALILASEETKNRKREEKKKALTLKWTQEFNRVYCKEIRKISMFDDEEESGKEEEQYEPPEKRTC 310
            |:.:                            .|.:.:::|                |.|
Yeast   220 ISFL----------------------------GYLRYVKQI----------------EGP----- 235

  Fly   311 HVKTKKINQFRILDDDDNDAGDKAVVEDEQKDLLAKTPEPEVFSSDEEEEHLSNGRYPSANTLVV 375
                                                                         .|::
Yeast   236 -------------------------------------------------------------FLII 239

  Fly   376 CPMSVMCQWAHEVASKVAQNAIRVLTFHGPNR------HEIGIEAFRSYDLVITSYNLVV---NE 431
            .|.|.:..|..|.. |...| :.||..||...      ..|.:||  .:|::||||.:|:   |.
Yeast   240 VPKSTLDNWRREFL-KWTPN-VNVLVLHGDKDTRADIVRNIILEA--RFDVLITSYEMVIREKNA 300

  Fly   432 LKRYGNTSPLFAVYWNRVILDEAHIIRNSKTNCCNSVCQLRAHCHWALTGTPVQNRGVDVFALLR 496
            |||         :.|..:::||||.|:|.::.....:....:.....:||||:||...:::|||.
Yeast   301 LKR---------LAWQYIVIDEAHRIKNEQSALSQIIRLFYSKNRLLITGTPLQNNLHELWALLN 356

  Fly   497 FVNVPNFQD---LQQWKKNLN---ESMLGHRRLNFIIKPLMLRRTKQKLQASGDMPALPSLKIEL 555
            |:....|.|   ..:|.:..|   :..:..::|:.::.|.:|||.|..::.|
Yeast   357 FLLPDIFGDSELFDEWFEQNNSEQDQEIVIQQLHSVLNPFLLRRVKADVEKS------------- 408

  Fly   556 ICVQLSKTEMAVYQILSAISKKIFTQFLLQREKGNSDLNYYSLERTPQFIAGHMSDERYNEIYER 620
               .|.|.|..||                   .|.:|                |..:.|..:.|:
Yeast   409 ---LLPKIETNVY-------------------VGMTD----------------MQIQWYKSLLEK 435

  Fly   621 FLKSLGYNPGEKILGIYILVLLLRLRQFCCHPGLMIGMLRGALTAEDVQNVKVDASDVEGQLKMD 685
            .:.::....|::.....:|.::::||:.|.||.|..|
Yeast   436 DIDAVNGAVGKREGKTRLLNIVMQLRKCCNHPYLFEG---------------------------- 472

  Fly   686 VLAELDKFDETDSEDDCCDEEDSTRRDGNFKLEVIKDEIKEENVPWDSGDDLPTASSFEDQLDSA 750
                                                   .|...|:.:.:.|
Yeast   473 ---------------------------------------AEPGPPYTTDEHL------------- 485

  Fly   751 RALKLLNPQNPIFQFIRPSAKLKMVIDKLEELLTGTNDKIIVTSQWVSYLAIVRKRLQDLSWETL 815
                       ||.    |.|: :::|||.:.|.....::::.||....|.|:........:|..
Yeast   486 -----------IFN----SGKM-IILDKLLKRLKEKGSRVLIFSQMSRLLDILEDYCYFRDFEYC 534

  Fly   816 DFNGQLTAKEREIVLRDFN-ANNEKRVLLLSLTAGGVGLNLNVANHMLIVDLHWNPQLERQAQDR 879
            ..:|..:.:||...:.::| .|:||.|.||:..|||:|:||..|:.:::.|..||||.:.||.||
Yeast   535 RIDGSTSHEERIEAIDEYNKPNSEKFVFLLTTRAGGLGINLVTADTVILFDSDWNPQADLQAMDR 599

  Fly   880 IYRYGQTKPTFIYRYMCQDTVEQRIKSLQDCKLEIAKVVLPEEGGEVTKCVGGG----LNLAEL- 939
            .:|.||.|...:||::.::.:|:::......||.:.::|:.:..|:.|..:|..    |::.:.
Yeast   600 AHRIGQKKQVHVYRFVTENAIEEKVIERAAQKLRLDQLVIQQGTGKKTASLGNSKDDLLDMIQFG 664

  Fly   940 -KKLFE 944
             |.:||
Yeast   665 AKNMFE 670

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10445	NP_649751.2	HepA	<113..919	CDD:440319	155/821 (19%)
		DEAD-like_helicase_N	209..534	CDD:475120	71/339 (21%)
ISW2	NP_014948.1	PLN03142	1..1093	CDD:215601	187/981 (19%)