DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10445 and ULS1

DIOPT Version :9

Sequence 1:	NP_001246974.1	Gene:	CG10445 / 40938	FlyBaseID:	FBgn0037531	Length:	945	Species:	Drosophila melanogaster
Sequence 2:	NP_014834.1	Gene:	ULS1 / 854363	SGDID:	S000005717	Length:	1619	Species:	Saccharomyces cerevisiae

Alignment Length:	1074	Identity:	244/1074 - (22%)
Similarity:	395/1074 - (36%)	Gaps:	360/1074 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 LELSGEYADNESA------------IFVSASEYN-----------EKKAQ-------IDQLVQKI 80
            ::::..:..:|||            :|.:..:|.           :::||       ...|:.|.
Yeast   725 IDINRRHVAHESAQILFTNGVKMPIVFETLQDYGIKFSNPAIVNPDRRAQYFKSIEVARDLISKS 789

  Fly    81 LTMEQQQRQLEENASETKEL-CDLKLHLEKLNARLEALGEFLDTL--------RLREDQQEIKIE 136
            ...|..:|::....:..:|. .|:.........:.|.:|:.:..|        ||.|:.:..||.
Yeast   790 TRSEDAKRKITRFLNIIEEFRKDIDTGFPPTPLKREGVGKAVVGLRQQGLKMDRLYENLRRYKIP 854

  Fly   137 DNSELV-----------DHTEQPKWSNLYSGLNRYRQKANHTAAQFYQHKSNI-----IDSLKTL 185
            ..||.:           |......| |:..........||..:.|...|.||:     .:.::.|
Yeast   855 ITSEELLQQSYLFPVNADQRPPSNW-NIVENTEDTSSTANDLSMQDEFHISNMHAAEDQEQIRAL 918

  Fly   186 YEPIQPRPAIDDLEK-QPALLLVRLLKHQQSCLKWMQFRERQKISGGILADDMGLGKTLSMIALI 249
            .|.::...:|.|.|. .|..:.|.|||||:..|.|:...|.....||:||||||||||:..|||:
Yeast   919 LENVKQSESIIDGEALTPEDMTVNLLKHQRLGLHWLLQVENSAKKGGLLADDMGLGKTIQAIALM 983

  Fly   250 LASEETKNRKREEKKKALTLKWTQEFNRVYCKEIRKISMFDDEEESGKEEEQYEPPEKRTCHVKT 314
            ||     ||..|.|                ||
Yeast   984 LA-----NRSEESK----------------CK--------------------------------- 994

  Fly   315 KKINQFRILDDDDNDAGDKAVVEDEQKDLLAKTPEPEVFSSDEEEEHLSNGRYPSANTLVVCPMS 379
                                                                    ..|:|.|:|
Yeast   995 --------------------------------------------------------TNLIVAPVS 1003

  Fly   380 VMCQWAHEVASKVAQNAIRVLTF------HGPNRHEIGIEAFRS---YDLVITSYNLVVNELKRY 435
            |:..|..|:.:||.:.| :..||      :|..:|      :|.   ||.|:.||..:.||.|::
Yeast  1004 VLRVWKGELETKVKKRA-KFTTFIFGGSGNGKVKH------WRDLARYDAVLVSYQTLANEFKKH 1061

  Fly   436 ------GNTSPLFAV--------------YWN----------RVILDEAHIIRNSKTNCCNSVCQ 470
                  |..:.|.||              |::          |::|||...|:|..|....:.|.
Yeast  1062 WPKKLDGEQNQLPAVPHIQALNRLKTSNEYYSPFFCNDSTFYRILLDEGQNIKNKNTRASKACCT 1126

  Fly   471 LRAHCHWALTGTPVQNRGVDVFALLRFVNVPNFQDLQQWKKNL-------------NESMLGH-R 521
            :.....|.|:|||:||...::::|:||:.:|.:...|::|.::             ||..... |
Yeast  1127 INGMYRWVLSGTPIQNSMDELYSLIRFLRIPPYHKEQRFKLDIGRFFQRNKQYQYDNEDRKNALR 1191

  Fly   522 RLNFIIKPLMLRRTKQKLQASGDMPALPSLKIELICVQLSKTEMAVYQIL----SAISKKIFTQF 582
            ::..::..:||||:|........:..||...:|:...:|...|:..|..|    .|::||:.
Yeast  1192 KVRVLLNAIMLRRSKADKIDGKPLLELPPKIVEVDESRLKGEELKFYTALESKNQALAKKLL--- 1253

  Fly   583 LLQREKGNSDLNYYSLERTPQFIAGHMSDERYNEIYERFLKSLGYNPGEKILGIYILVLLLRLRQ 647
                  .||....||                                       .:|.|||||||
Yeast  1254 ------NNSTRGSYS---------------------------------------SVLTLLLRLRQ 1273

  Fly   648 FCCHPGLMIGMLRGALTAE--DVQNVKVDASD----------VEGQLKMDVLAELDK------FD 694
            .|||..|::   .|...||  .|.|.|....|          :.|:.:..|:..::.      .:
Yeast  1274 ACCHSELVV---MGEKKAEGTKVANGKSFEDDWLRLYYKITHMSGEAQAQVITSMNSMTCFWCME 1335

  Fly   695 ETDSE-------------DDCCD---EEDS------TRRDGNFKL-------------------- 717
            :.:.|             |.|.:   ||.|      ..:.|.|.:
Yeast  1336 QLEPEAMSVLTGCGHLICDTCIEPFIEESSMLPQAKKTKGGAFAIPCKDCQRLTNEKDIVSHKLY 1400

  Fly   718 -EVIKDEIKEENVPWDSGDDLPTASSFEDQLDSARALKLLNPQNPIFQFIRPSAKLKMVIDKLEE 781
             :||.....||::      .....|..|.|     .::..|...|.|:.:.||.|::..|..::.
Yeast  1401 DQVINQGFTEEDL------HAEYLSEMEKQ-----KIQQKNVYVPNFESLEPSTKIEQCIQVIQR 1454

  Fly   782 LL-TGTNDKIIVTSQWVSYLAIVRKRLQD-LSWETLDFNGQLTAKEREIVLRDFNANNEKRVLLL 844
            :. ....:|||:.||:.::..|:...|:: |::..|.:.|.:.|:.|..|:.:|..:.|||:||:
Yeast  1455 VFDESATEKIIIFSQFTTFFEILEHFLKNKLNFPYLKYIGSMNAQRRSDVINEFYRDPEKRILLI 1519

  Fly   845 SLTAGGVGLNLNVANHMLIVDLHWNPQLERQAQDRIYRYGQTKPTFIYRYMCQDTVEQRIKSLQD 909
            |:.||..||.|..|||::|||..|||.:|.|||||.||..|||...:::...:|:||.||..||.
Yeast  1520 SMKAGNSGLTLTCANHVVIVDPFWNPYVEEQAQDRCYRISQTKKVQVHKLFIKDSVEDRISELQK 1584

  Fly   910 CKLEIAKVVLPEEGGEVTKCVGGGLNLAELKKLF 943
            .|.|:....:  :.|::.:.  ..|...||..||
Yeast  1585 RKKEMVDSAM--DPGKIKEV--NSLGRRELGFLF 1614

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10445	NP_001246974.1	HepA	<90..945	CDD:223627	233/1000 (23%)
CG10445	NP_001246974.1	DEAD-like_helicase_N	209..534	CDD:421690	85/377 (23%)
ULS1	NP_014834.1	HepA	629..1617	CDD:223627	244/1074 (23%)
ULS1	NP_014834.1	DEXDc_SHPRH-like	943..1204	CDD:350766	85/377 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	305	1.000	Inparanoid score	I488
Isobase	1	0.950	-	0	Normalized mean entropy	S3486
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000507
OrthoInspector	1	1.000	-	-		mtm9251
orthoMCL	1	0.900	-	-		OOG6_101296
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2250
SonicParanoid	1	1.000	-	-		X1278
TreeFam	1	0.960	-	-
	9	8.800