Protein Alignment CG10445 and RAD26

DIOPT Version :10

• Sequence 1: NP_649751.2
• Gene: CG10445 / 40938
• FlyBaseID: FBgn0037531
• Length: 945
• Species: Drosophila melanogaster
• Sequence 2: NP_012569.1
• Gene: RAD26 / 853492
• SGDID: S000003796
• Length: 1085
• Species: Saccharomyces cerevisiae
• Alignment Length: 928
• Identity: 193/928 - (20%)
• Similarity: 328/928 - (35%)
• Gaps: 347/928 - (37%)

  Fly    51 EYADNESAIFVSASEYNEKKAQ-----IDQLVQKI------LTMEQQQRQLEENASETKELCDLK 104
            |||.|:           |:|.:     .:|:|:.:      |:.:..|...:|:..:.:|..|.|
Yeast   168 EYAKND-----------EQKDEDFEMATEQMVENLTDEDDNLSDQDYQMSGKESEDDEEEENDDK 221

  Fly   105 LHLEKLNARLEALGEFLDTLRLREDQQEIKIEDNSELVDHTEQPKW-------SNLYSGLNRYRQ 162
            :..|            |:.||.|....|.| :|..||.......||       |...|.|..:|
Yeast   222 ILKE------------LEDLRFRGQPGEAK-DDGDELYYQERLKKWVKQRSCGSQRSSDLPEWR- 272

  Fly   163 KANHTAAQFYQHKSNIIDSLKTLYEPIQPRPAIDDLE-----KQPALLLVRLLKHQQSCLKWMQF 222
                                       :|.|.|.|.:     |.|..:...|..:|::|::|: :
Yeast   273 ---------------------------RPHPNIPDAKLNSQFKIPGEIYSLLFNYQKTCVQWL-Y 309

  Fly   223 RERQKISGGILADDMGLGKTLSMIALILASEETKNRKREEKKKALT------------LKWTQEF 275
            ...|:..|||:.|:||||||:.:||.|.|...:         ..||            .:|..||
Yeast   310 ELYQQNCGGIIGDEMGLGKTIQVIAFIAALHHS---------GLLTGPVLIVCPATVMKQWCNEF 365

  Fly   276 NRVYCKEIRKISMFDDEEESGKEEEQYEPPEKRTCHVKTKKINQFRILDDDDNDAGDKAVVEDEQ 340
            .. :...:|.:.:  ....||...:|                 :|::   |:||.
Yeast   366 QH-WWPPLRTVIL--HSMGSGMASDQ-----------------KFKM---DENDL---------- 397

  Fly   341 KDLLAKTPEPEVFSSDEEEEHLSNGRYPSANTLVVCPMSVMCQWAHEVASKVAQNAIRVLTFHGP 405
             :.|....:|..||.::                          |.:...:|.|..:    ::|
Yeast   398 -ENLIMNSKPSDFSYED--------------------------WKNSTRTKKALES----SYH-- 429

  Fly   406 NRHEIGIEAFRSYDLVITSYNLVVNELKRYG---NTSPLFAVYWNRVILDEAHIIRNSKTNCCNS 467
                    ..:..|.|:|..::::...  .|   ::..|..|.|...:|||.|.|||..:....:
Yeast   430 --------LDKLIDKVVTDGHILITTY--VGLRIHSDKLLKVKWQYAVLDEGHKIRNPDSEISLT 484

  Fly   468 VCQLRAHCHWALTGTPVQNRGVDVFALLRFV------NVPNFQDLQQWKKNLN----------ES 516
            ..:|:.|....|:|||:||...::::|..|:      .:|.||  ||:...:|          :.
Yeast   485 CKKLKTHNRIILSGTPIQNNLTELWSLFDFIFPGKLGTLPVFQ--QQFVIPINIGGYANATNIQV 547

  Fly   517 MLGHR---RLNFIIKPLMLRRTKQKLQASGDMPALPSLKIELICVQLSKTEMAVYQILSAISKKI 578
            ..|::   .|..:|.|.:|||.  |...:.|:|              .|.||.::..|:...:..
Yeast   548 QTGYKCAVALRDLISPYLLRRV--KADVAKDLP--------------QKKEMVLFCKLTKYQRSK 596

  Fly   579 FTQFLLQREKGNSDLNYYSLERTPQFIAGHMSDERYNEIYERFLKSLGYNPGEKILGIYILVLLL 643
            :.:||     .:||||             .:.:.:.|.::                ||.|
Yeast   597 YLEFL-----HSSDLN-------------QIQNGKRNVLF----------------GIDI----- 622

  Fly   644 RLRQFCCHPGLMIGMLRGALTAEDVQNVKVDASDVEGQLKMDVLAELDKFDETDSEDDCCDEEDS 708
             ||:.|.||.|:         ..|.:....|..|
Yeast   623 -LRKICNHPDLL---------DRDTKRHNPDYGD------------------------------- 646

  Fly   709 TRRDGNFKLEVIKDEIKEENVPWDSGDDLPTASSFEDQLDSARALKLLNPQNPIFQFIRPSAKLK 773
            .:|.|  |::|:|..:    :.|..                 :..|.|     :|      .:.:
Yeast   647 PKRSG--KMQVVKQLL----LLWHK-----------------QGYKAL-----LF------TQSR 677

  Fly   774 MVIDKLEELLTGTNDKIIVTSQWVSYLAIVRKRLQDLSWETLDFNGQLTAKEREIVLRDFNANNE 838
            .::|.|||.:: |.|..:      |:|..:|            .:|....|.|:.::..|| |..
Yeast   678 QMLDILEEFIS-TKDPDL------SHLNYLR------------MDGTTNIKGRQSLVDRFN-NES 722

  Fly   839 KRVLLLSLTAGGVGLNLNVANHMLIVDLHWNPQLERQAQDRIYRYGQTKPTFIYRYMCQDTVEQR 903
            ..|.||:...||:|:||..||.::|.|..|||..:.||::|.:|.||.:...|||.|...::|::
Yeast   723 FDVFLLTTRVGGLGVNLTGANRIIIFDPDWNPSTDMQARERAWRIGQKREVSIYRLMVGGSIEEK 787

  Fly   904 IKSLQDCKLEIAKVVLPE 921
            |...|..|..:...:|.:
Yeast   788 IYHRQIFKQFLTNRILTD 805

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10445	NP_649751.2	HepA	<113..919	CDD:440319	177/851 (21%)
		DEAD-like_helicase_N	209..534	CDD:475120	75/358 (21%)
RAD26	NP_012569.1	HepA	<222..792	CDD:440319	176/848 (21%)
		CSB_WHD	1019..1080	CDD:439329