DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10445 and RAD16

DIOPT Version :9

Sequence 1:	NP_001246974.1	Gene:	CG10445 / 40938	FlyBaseID:	FBgn0037531	Length:	945	Species:	Drosophila melanogaster
Sequence 2:	NP_009672.1	Gene:	RAD16 / 852411	SGDID:	S000000318	Length:	790	Species:	Saccharomyces cerevisiae

Alignment Length:	985	Identity:	207/985 - (21%)
Similarity:	384/985 - (38%)	Gaps:	311/985 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 EYADNESAIFVSASEYNEKKAQIDQLVQKILTMEQQQRQLEENASETKELCDLKLHLEKLNARLE 115
            |.:|:::|:      .|.|..|:....:.:  .:.|..:..::|:..|...|     :..:..::
Yeast    23 ELSDDDTAV------KNSKTLQLKGNSENV--NDSQDEEYRDDATLVKSPDD-----DDKDFIID 74

  Fly   116 ALGEFLDTLRLREDQQEIKIEDNSELVDHTEQPKWSNLYSGLNR-----YRQKANHTAA------ 169
            ..|...:.....|:...|| .||.|:::..|:...|:....|.:     .|:|...|:.
Yeast    75 LTGSDKERTATDENTHAIK-NDNDEIIEIKEERDVSDDDEPLTKKRKTTARKKKKKTSTKKKSPK 138

  Fly   170 ---------QFYQHK---SNIIDSLKTLYEPIQPRPAIDDLEKQPALLLVRLLKHQQSCLKWMQF 222
                     :.|:|.   .|:...||      ...|.:....|||..:.::||..|...|.|:..
Yeast   139 VTPYERNTLRLYEHHPELRNVFTDLK------NAPPYVPQRSKQPDGMTIKLLPFQLEGLHWLIS 197

  Fly   223 RERQKISGGILADDMGLGKTLSMIALILASEETKNRKREEKKKALTLKWTQEFNRVYCKEIRKIS 287
            :|....:||:|||:||:|||:..|||::
Yeast   198 QEESIYAGGVLADEMGMGKTIQTIALLM------------------------------------- 225

  Fly   288 MFDDEEESGKEEEQYEPPEKRTCHVKTKKINQFRILDDDDNDAGDKAVVEDEQKDLLAKTPEPEV 352
                                                    ||              |.|:|
Yeast   226 ----------------------------------------ND--------------LTKSP---- 232

  Fly   353 FSSDEEEEHLSNGRYPSANTLVVCPMSVMCQWAHEVASKVAQNAIRVLTFHGPNRHEIGIEAFRS 417
                               :|||.|...:.||.:|: .:..:..:::..:||.:| ...|:..:.
Yeast   233 -------------------SLVVAPTVALMQWKNEI-EQHTKGQLKIYIYHGASR-TTDIKDLQG 276

  Fly   418 YDLVITSYNLVVNELKR--YG---------NTSPLFAVYWNRVILDEAHIIRNSKTNCCNSVCQL 471
            ||:|:|:|.::.:..::  ||         ..|.|..:.:.||||||||.|::.::|...:|..|
Yeast   277 YDVVLTTYAVLESVFRKQNYGFRRKNGLFKQPSVLHNIDFYRVILDEAHNIKDRQSNTARAVNNL 341

  Fly   472 RAHCHWALTGTPVQNRGVDVFALLRFVNVPNFQDL---------QQWK----------------- 510
            :....|.|:|||:|||..::::|:||:|:..|...         :.||
Yeast   342 KTQKRWCLSGTPLQNRIGEMYSLIRFLNINPFTKYFCTKCDCASKDWKFTDRMHCDHCSHVIMQH 406

  Fly   511 ---------KNLNE------SMLGHRRLNFIIKPLMLRRTKQKLQASGDMPALPSLKIELICVQ- 559
                     ||:.:      .:.....:..::|.:|||||  |::.:.|:...|    .::.|:
Yeast   407 TNFFNHFMLKNIQKFGVEGPGLESFNNIQTLLKNIMLRRT--KVERADDLGLPP----RIVTVRR 465

  Fly   560 --LSKTEMAVYQILSAISKKIFTQFLLQREKGNSDLNYYSLERTPQFIAGHMSDERYNEIYERFL 622
              .::.|..:|:.|...||:.:..|:   |:|....||.:
Yeast   466 DFFNEEEKDLYRSLYTDSKRKYNSFV---EEGVVLNNYAN------------------------- 502

  Fly   623 KSLGYNPGEKILGIYILVLLLRLRQFCCHPGLMIGMLRGALTAEDVQNVKVDASDVEGQ------ 681
                           |..|:.|:||...||.|::..|.. ...:|:..|.....:.|.:
Yeast   503 ---------------IFTLITRMRQLADHPDLVLKRLNN-FPGDDIGVVICQLCNDEAEEPIESK 551

  Fly   682 -----LKMDVLAELDKFDETDSEDDC--CDEEDSTRRDGNFKLEVIKDEIKEENVPWDSGDDLPT 739
                 .::.:...::.|.|.:::..|  |          :..|.:                || :
Yeast   552 CHHKFCRLCIKEYVESFMENNNKLTCPVC----------HIGLSI----------------DL-S 589

  Fly   740 ASSFEDQLDSARALKLLNPQNPIFQFIRPSAKLKMVIDKLEELLTGTND-KIIVTSQWVSYLAIV 803
            ..:.|..|||.:...:::..|...:: :.|.|::.::::|.:|.:.... |.||.||:.|.|.:|
Yeast   590 QPALEVDLDSFKKQSIVSRLNMSGKW-QSSTKIEALVEELYKLRSNKRTIKSIVFSQFTSMLDLV 653

  Fly   804 RKRLQDLSWETLDFNGQLTAKEREIVLRDFNANNEKRVLLLSLTAGGVGLNLNVANHMLIVDLHW 868
            ..||:...::|:...|.::..:|:..::.|..|.:..|.|:||.||||.|||..|:.:.|:|..|
Yeast   654 EWRLKRAGFQTVKLQGSMSPTQRDETIKYFMNNIQCEVFLVSLKAGGVALNLCEASQVFILDPWW 718

  Fly   869 NPQLERQAQDRIYRYGQTKPTFIYRYMCQDTVEQRIKSLQDCKLEIAKVVLPEEGGEVTKCVGGG 933
            ||.:|.|:.||::|.||.:|..|.|:..:|::|.||..||:.|..:....:.::...:::
Yeast   719 NPSVEWQSGDRVHRIGQYRPVKITRFCIEDSIEARIIELQEKKANMIHATINQDEAAISR----- 778

  Fly   934 LNLAELKKLF 943
            |..|:|:.||
Yeast   779 LTPADLQFLF 788

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10445	NP_001246974.1	HepA	<90..945	CDD:223627	200/946 (21%)
CG10445	NP_001246974.1	DEAD-like_helicase_N	209..534	CDD:421690	76/376 (20%)
RAD16	NP_009672.1	HepA	<55..788	CDD:223627	198/943 (21%)
RAD16	NP_009672.1	RAD18	537..>642	CDD:227719	18/132 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0141
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3486
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000507
OrthoInspector	1	1.000	-	-		mtm9251
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2250
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.790