Protein Alignment CG10445 and RDH54

DIOPT Version :10

• Sequence 1: NP_649751.2
• Gene: CG10445 / 40938
• FlyBaseID: FBgn0037531
• Length: 945
• Species: Drosophila melanogaster
• Sequence 2: NP_009629.6
• Gene: RDH54 / 852365
• SGDID: S000000277
• Length: 958
• Species: Saccharomyces cerevisiae
• Alignment Length: 964
• Identity: 201/964 - (20%)
• Similarity: 322/964 - (33%)
• Gaps: 338/964 - (35%)

  Fly    55 NESAIFVSASEYNEKKAQIDQLVQKILTMEQQQRQLEENASETKELCDLKLHLEKLNARLEALGE 119
            ||:..|:.:|..   .:..|.|.:.:......:.||:....|..|:...|          |||.:
Yeast   142 NEAGKFLGSSML---PSDSDSLFETLFKAGSNEVQLDYELKENAEIRSAK----------EALSQ 193

  Fly   120 FLDTLRLREDQQEIKIEDNSELVDHTE------QPKWSNLYSGLNRYRQKANHTAAQFYQHKSNI 178
            .:       ..........:|.|..|:      |...|.|:| ||..::..:.| .|..:|.:.:
Yeast   194 NM-------GNPSPPTTSTTETVPSTKNDGGKYQMPLSQLFS-LNTVKRFKSVT-KQTNEHMTTV 249

  Fly   179 ----IDSLKTLYEPIQPRPAIDD---LEKQPAL--------LLVRLLK-HQQSCLKWMQ------ 221
                .:|....|.|:.....||:   :.|..|.        ||.:.|: ||:..:|:|.
Yeast   250 PKTSQNSKAKKYYPVFDVNKIDNPIVMNKNAAAEVDVIVDPLLGKFLRPHQREGVKFMYDCLMGL 314

  Fly   222 ------------------FRERQKISGGILADDMGLGKTLSMIALILASEETKNRKREEKKKALT 268
                              ......|||.:|||||||||||..|.||..                .
Yeast   315 ARPTIENPDIDCTTKSLVLENDSDISGCLLADDMGLGKTLMSITLIWT----------------L 363

  Fly   269 LKWTQEFNRVYCKEIRKISMFDDEEESGKEEEQYEPPEKRTCHVKTKKINQFRILDDDDNDAGDK 333
            ::.|...::|.|            .:||       .|....|    |||
Yeast   364 IRQTPFASKVSC------------SQSG-------IPLTGLC----KKI---------------- 389

  Fly   334 AVVEDEQKDLLAKTPEPEVFSSDEEEEHLSNGRYPSANTLVVCPMSVMCQWAHEVASKVAQNAIR 398
                                                   |||||::::..|..|....:..:.|.
Yeast   390 ---------------------------------------LVVCPVTLIGNWKREFGKWLNLSRIG 415

  Fly   399 VLTF---HGPNRHEIGIEAF----RSYDLVITSYNLVVNELKRYGNTSPLFAVYWNRVILDEAHI 456
            |||.   :.|:..::.:..|    |:|.::|..|..:::..:.......|.    :.::.||.|.
Yeast   416 VLTLSSRNSPDMDKMAVRNFLKVQRTYQVLIIGYEKLLSVSEELEKNKHLI----DMLVCDEGHR 476

  Fly   457 IRNSKTNCCNSVCQLRAHCHWALTGTPVQNRGVDVFALLRFVNVPNFQDLQQWKKNL-------- 513
            ::|..:...|::..|.......|||||:||...:.|.::.|:|.........:|:..
Yeast   477 LKNGASKILNTLKSLDIRRKLLLTGTPIQNDLNEFFTIIDFINPGILGSFASFKRRFIIPITRAR 541

  Fly   514 ------NESML--GHRRLNFII---KPLMLRRTKQKLQASGDMPALPSLKIELICVQLSKTEMAV 567
                  ||.:|  |..|...:|   |..:||||...|:..  :|  |...|.|.|...|:..:|.
Yeast   542 DTANRYNEELLEKGEERSKEMIEITKRFILRRTNAILEKY--LP--PKTDIILFCKPYSQQILAF 602

  Fly   568 YQILSAISKKIFTQFLLQREKGNSDLNYYSLERTPQFIAGHMSDERYNEIYERFLKSLGYNPGEK 632
            ..||.                 .:.|::..|                     .|..|||
Yeast   603 KDILQ-----------------GARLDFGQL---------------------TFSSSLG------ 623

  Fly   633 ILGIYILVLLLRLRQFCCHPGLMIGMLRGALTAEDVQNVKVDASDVEGQLKMDVLAELDKFDETD 697
                    |:..|::.|..|||:                   .||
Yeast   624 --------LITLLKKVCNSPGLV-------------------GSD-------------------- 641

  Fly   698 SEDDCCDEEDSTRRDGNFKLEVIKDEIKEENVPWDSGDDLPTASSFEDQLDSARALKLLNPQNPI 762
                                ...|..||          |..:..|:...|:
Yeast   642 --------------------PYYKSHIK----------DTQSQDSYSRSLN-------------- 662

  Fly   763 FQFIRPSAKLKMVIDKLEELLTGTNDKIIVTSQWVSYLAIVRKRLQDLSWETLDFNGQLTAKERE 827
                  |.|||:::..||.:..||.:|::|.|.:...|.|:...:..........:|.:.||:|:
Yeast   663 ------SGKLKVLMTLLEGIRKGTKEKVVVVSNYTQTLDIIENLMNMAGMSHCRLDGSIPAKQRD 721

  Fly   828 IVLRDFNANNEKRVLLLSLTAGGVGLNLNVANHMLIVDLHWNPQLERQAQDRIYRYGQTKPTFIY 892
            .::..||.|......|||..:|||||||..|:.:::.|..|||.::.||..||:|.||.||.|||
Yeast   722 SIVTSFNRNPAIFGFLLSAKSGGVGLNLVGASRLILFDNDWNPSVDLQAMSRIHRDGQKKPCFIY 786

  Fly   893 RYMCQDTVEQRIKSLQDCKLEIAKVVLPEEGGEVTKCVGGGL-NLAELKKLFEM 945
            |.:....::::|...|..|..:::..|.:......:.....| |..:||.||.:
Yeast   787 RLVTTGCIDEKILQRQLMKNSLSQKFLGDSEMRNKESSNDDLFNKEDLKDLFSV 840

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10445	NP_649751.2	HepA	<113..919	CDD:440319	183/877 (21%)
		DEAD-like_helicase_N	209..534	CDD:475120	75/375 (20%)
RDH54	NP_009629.6	DUF2439	108..>158	CDD:463065	4/18 (22%)
		DEXHc_RAD54	296..573	CDD:350762	75/374 (20%)
		SF2_C_SNF	663..789	CDD:350180	48/125 (38%)