Protein Alignment CG10445 and FUN30

DIOPT Version :10

• Sequence 1: NP_649751.2
• Gene: CG10445 / 40938
• FlyBaseID: FBgn0037531
• Length: 945
• Species: Drosophila melanogaster
• Sequence 2: NP_009383.1
• Gene: FUN30 / 851214
• SGDID: S000000017
• Length: 1131
• Species: Saccharomyces cerevisiae
• Alignment Length: 1000
• Identity: 213/1000 - (21%)
• Similarity: 372/1000 - (37%)
• Gaps: 285/1000 - (28%)

  Fly     1 MESSSPSDTTEIHKQSCSIQDQSSVPVPDSSGEINNWMEPEPVDSLELSGEYADNESAIFVSASE 65
            ::.|..|||| :||....   .|..|....:..:|.....:..:      |.|.|:.....:||.
Yeast   293 VDLSDLSDTT-MHKAQLI---ASHRPYSSLNAFVNTNFNDKDTE------ENASNKRKRRAAASA 347

  Fly    66 YNEKKAQIDQLVQKILTMEQQQRQLEENASETKELCDL-KLHLEKLNARLEALGEFLDTLRLRED 129
             ||.:..:|::.|.|    :....:|....:.....|| ...::|...::|.....||.:.|.||
Yeast   348 -NESERLLDKITQSI----RGYNAIESVIKKCSSYGDLVTSQMKKWGVQVEGDNSELDLMNLGED 407

  Fly   130 QQEIKIEDNSELVDHTEQPKWSNLYSGLNRYRQKANHTAAQFYQHKSNIIDSLKTLYEPIQPRPA 194
            ..    :||.   |.......||     |.....|:.|:.:....|:.:....:|..|| .|.||
Yeast   408 DD----DDND---DGNNDNNNSN-----NNNTAGADATSKEKEDTKAVVEGFDETSAEP-TPAPA 459

  Fly   195 IDDLEKQPALLLVRLLKHQQSCLKWMQFRERQKISGGILADDMGLGKTLSMIALILASEETKNRK 259
            ...:|                       ||.::|                       ...||.:.
Yeast   460 PAPVE-----------------------RETKRI-----------------------RNTTKPKV 478

  Fly   260 REEKKKALTLKWTQEFNRVYCKEIRKISMFDDEEESGKEEEQYEPPEKRTCHVKTKKINQFRILD 324
            .|::...:.|:...:       |:.:....||:.|  :|:|.|...|:..         ::...|
Yeast   479 VEDEDDDVDLEAIDD-------ELPQSEHEDDDYE--EEDEDYNDEEEDV---------EYDDGD 525

  Fly   325 DDDNDAGDKAVVEDEQKDLLAKTP------------------EPEVFSSDEEEEHLS--NGRYPS 369
            |||:| .|:.|...:...:::.|.                  .||:...|.::..::  |..|.:
Yeast   526 DDDDD-DDEFVATRKNTHVISTTSRNGRKPIVKFFKGKPRLLSPEISLKDYQQTGINWLNLLYQN 589

  Fly   370 ANT-------------------------------LVVCPMSVMCQWAHEVASKVAQNAIRVLTFH 403
            ..:                               |||.|.|.:..|..|. .|.|. |:::..::
Yeast   590 KMSCILADDMGLGKTCQVISFFAYLKQINEPGPHLVVVPSSTLENWLREF-QKFAP-ALKIEPYY 652

  Fly   404 G--PNRHEIGIEAFRS---YDLVITSYNLVVNELKRYGNTSPLFAVYWNRVILDEAHIIRNSKTN 463
            |  ..|.|:.....|:   ||:::|:|||...  .:| :.|.|....:|.|:.||.|:::||.:.
Yeast   653 GSLQEREELRDILERNAGKYDVIVTTYNLAAG--NKY-DVSFLKNRNFNVVVYDEGHMLKNSTSE 714

  Fly   464 CCNSVCQLRAHCHWALTGTPVQNRGVDVFALLRFVNVPN--------FQDLQQWKKNLNESMLGH 520
            ....:.::||:....|||||:||...::.:||.|: :||        |..:.:.:....:....|
Yeast   715 RFAKLMKIRANFRLLLTGTPLQNNLKELMSLLEFI-MPNLFISKKESFDAIFKQRAKTTDDNKNH 778

  Fly   521 R---------RLNFIIKPLMLRRTKQKLQASGDMPALPSLKIELICVQLSKTEMAVYQILSAISK 576
            .         |...::||.:|||.|.::     :..||           .|.....|..|:||.|
Yeast   779 NPLLAQEAITRAKTMMKPFILRRRKDQV-----LKHLP-----------PKHTHIQYCELNAIQK 827

  Fly   577 KIFTQFLLQREKGNSDLNYYSLERTPQFIAGHMSDERYNEIYERFLKSLGYNPGE-----KILGI 636
            ||:                   ::..|.:..|          :|.:|. |..|.:     |:...
Yeast   828 KIY-------------------DKEIQIVLEH----------KRMIKD-GELPKDAKEKSKLQSS 862

  Fly   637 YILVLLLRLRQFCCHPGLMIGMLRGALTAEDVQNVKVDASDVEGQLKMDVLAELDKFDETDSEDD 701
            ....|::.||:...||          |...::.|.|:..       ||               .|
Yeast   863 SSKNLIMALRKASLHP----------LLFRNIYNDKIIT-------KM---------------SD 895

  Fly   702 CCDEEDSTRRDGNFKLEVIKDEIKEENVPWDSGDDLPTASSFEDQLDSARALKL-LNPQNPIFQF 765
            ...:|.:...:||      |:.|||         |:...:.||       ..|| .|..|.:.::
Yeast   896 AILDEPAYAENGN------KEYIKE---------DMSYMTDFE-------LHKLCCNFPNTLSKY 938

  Fly   766 ------IRPSAKLKMVIDKLEELLTGTNDKIIVTSQWVSYLAIVRKRLQDLSWETLDFNGQLTAK 824
                  ...|.|:..:...|:.::....:|:::.|.:...|.|:...|..|.::.|..:|.....
Yeast   939 QLHNDEWMQSGKIDALKKLLKTIIVDKQEKVLIFSLFTQVLDILEMVLSTLDYKFLRLDGSTQVN 1003

  Fly   825 EREIVLRDFNANNEKRVLLLSLTAGGVGLNLNVANHMLIVDLHWNPQLERQAQDRIYRYGQTKPT 889
            :|::::..|..:.:..:.:||..|||.|:||..||:::|.|..:||..:|||.||.:|.||||..
Yeast  1004 DRQLLIDKFYEDKDIPIFILSTKAGGFGINLVCANNVIIFDQSFNPHDDRQAADRAHRVGQTKEV 1068

  Fly   890 FIYRYMCQDTVEQRIKSLQDCKLEI 914
            .|...:.:|::|::|..|...||.:
Yeast  1069 NITTLITKDSIEEKIHQLAKNKLAL 1093

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10445	NP_649751.2	HepA	<113..919	CDD:440319	189/886 (21%)
		DEAD-like_helicase_N	209..534	CDD:475120	78/397 (20%)
FUN30	NP_009383.1	HepA	<571..1093	CDD:440319	142/627 (23%)