Protein Alignment CG10445 and IRC20

DIOPT Version :10

• Sequence 1: NP_649751.2
• Gene: CG10445 / 40938
• FlyBaseID: FBgn0037531
• Length: 945
• Species: Drosophila melanogaster
• Sequence 2: NP_013348.1
• Gene: IRC20 / 850949
• SGDID: S000004237
• Length: 1556
• Species: Saccharomyces cerevisiae
• Alignment Length: 1128
• Identity: 197/1128 - (17%)
• Similarity: 375/1128 - (33%)
• Gaps: 486/1128 - (43%)

  Fly     9 TTEIHKQSCSIQDQSSV--PVPDSSGEINNWMEP-EPVDSLELSGEYADNESAIFVSASEY---- 66
            |.::.|....:.:.:||  .:|:.....||..:. :.:..:|:.....|||:.:.||:...
Yeast    46 TQKVSKNGKELINVASVNIEIPERISLSNNGRQLFKFIVDIEILPCENDNEATLVVSSDSVSLFQ 110

  Fly    67 ------NEKKAQIDQ---LVQKILTMEQQQR----QLE-----------------ENASETKELC 101
                  |..|..:|:   |:..|...:.|:|    |||                 .|.::.::|.
Yeast   111 IGFKMENNSKIAVDKQLPLILDICAHKNQERALRNQLENRKSLERKPSRKRRKKNSNVNDPEKLL 175

  Fly   102 DLKLH-------------------------LEKLNARLEALGEFLDTLRLREDQQEIKIEDNSEL 141
            ..::|                         :...|.:|:.|....:         ...:|.| ::
Yeast   176 KSRIHELSLSYKDFECSPVVFRYNDSSLTWVLSFNLKLKFLNNKFN---------RFSVEAN-QI 230

  Fly   142 VDHTEQPKWSNLYSGLNRYRQKANHTAAQFYQHK--SNIIDSLKTLYEPIQP--RPAIDDLEKQP 202
            :|.|...:..|.:   .|| .|.:|..:.|.|.:  |.|::..|.....|:|  ..:|.||:
Yeast   231 LDLTFSNRDENEF---ERY-HKHSHIHSNFIQKQFISQILEYSKDRLSKIKPFLPQSIPDLK--- 288

  Fly   203 ALLLVRLLKHQQSCLKWMQFRE------------------------------------------- 224
                |.||..|:..::||..:|
Yeast   289 ----VNLLPFQRESVEWMLIKEGHGNSLSDTPTVIDEVGLIDFMNEYYAYGYELIARSPDEVGPS 349

  Fly   225 ------------------------RQKISG-------GILADDMGLGKTLSMIALILASEETKNR 258
                                    ::::||       |:||::||||||:.:::|||.     ||
Yeast   350 LLWNKLTGYILTTEDAAHLYNQYRKERLSGDYPVCAKGVLAEEMGLGKTIEILSLILL-----NR 409

  Fly   259 KREEKKKALTLKWTQEFNRVYCKEIRKISMFDDEEESGKEEEQYEPPEKRTCHVKTKKINQFRIL 323
            ::.:..:|                    :..||              |.||. .|||
Yeast   410 RKLKDSEA--------------------TFIDD--------------ENRTI-TKTK-------- 431

  Fly   324 DDDDNDAGDKAVVEDEQKDLLAKTPEPEVFSSDEEEEHLSNGRYPSANTLVVCPMSVMCQWAHEV 388
                                                           .||::||.:::.||..|:
Yeast   432 -----------------------------------------------TTLIICPNAILKQWLEEI 449

  Fly   389 ASKVAQNAIRVLTFHGPNRHEI---------GIEAFRSYDLVITSYNLVVNEL------------ 432
              ::..|:::..|:.|.|  ||         .::....||:::||||::..|:
Yeast   450 --ELHANSLKWYTYRGYN--EIMKDCKTVDEAVQQLCQYDIIVTSYNIIATEVHHAEFNRSIRSR 510

  Fly   433 ----KRYGNTSPLFAVYWNRVILDEAHIIRNSKTNC--CNSVCQLRAHCHWALTGTPVQNRGVDV 491
                .:|..:|||..:.:.|:||||..::|:|.|..  |.|:.. |.|. |.::|||:||    :
Yeast   511 RLKSPKYDYSSPLALMQFYRIILDEVQMLRSSSTYSAKCTSLLH-RIHT-WGVSGTPIQN----I 569

  Fly   492 F---ALLRFVNVPNFQDLQQWKKNLNESMLGHRRLNFIIKPLMLRRTKQKLQASGDMPALPSLKI 553
            :   .::.::.:..|.|...:.:.|.|.             :.||...:...::..:..|..::.
Yeast   570 YNFRMIMSYLKLHPFCDEVDFIRTLQEE-------------IKLRNEAKDYTSNDFVCQLKGVRF 621

  Fly   554 EL-----------ICVQLSKTEMAVYQILSAISKKIFTQFLLQREKGNSDLNY-YSLERTPQFIA 606
            .:           :|::.||..:|             :|..:.|:.     |: ..||..|
Yeast   622 SIKDCMNIFYRYDLCIRHSKANVA-------------SQIHIPRQH-----NFIIPLEFAP---- 664

  Fly   607 GHMSDERYNEIYERFLKSLGYNP----GEKILGIYILVLLLRLRQFCCH---PGLMI-------G 657
              :..:.|..::..||:..|||.    ..::...::...|.|||..|||   |.::.       |
Yeast   665 --IEWDNYLNLWNNFLELSGYNSDGSGSPRVSNAFLNEWLSRLRYICCHALFPEILSTRQKRLHG 727

  Fly   658 MLRGALTAEDVQ-NVKVDASD------------------------------VEGQLKM--DVLAE 689
            .|......:|:. ::::||.|                              :|..:|:  |::..
Yeast   728 HLSRISNIDDILISMRMDAFDSLIGYYRERFHLSIKQAQYELEISNTPAKALESFIKIRDDLMIH 792

  Fly   690 L-------DKFDE----TDSEDDCCDEE---------DSTRRD---------------------- 712
            :       |.||:    ::.||:..||.         |.:.|:
Yeast   793 IRQKFNVEDPFDKSLNLSEDEDEHMDERFGEKETSSGDESDREINGAKNHDNHNNDGMLSNHLKK 857

  Fly   713 ------------------------GNFKLEVIKDEIKEENVPWDSGDDLPTASSF-EDQLDSARA 752
                                    |..|||...|:.::|..     :::..:..| :::|:....
Yeast   858 KGLRAMMNLLHDCYFFLGSVYYNLGTRKLEEADDKHRKEKT-----EEVVYSDVFPKNELEEIEE 917

  Fly   753 LKLLNPQN-PIFQFIRPS----------AKLKMVIDKLEELLTGTNDKII-----VTSQWVSYLA 801
            .:||..:| ...:.:|.|          ..:||...|...:.:....::|     ..:.:.|.||
Yeast   918 NRLLEQENYANAEILRKSILSSEARKVDMTIKMARTKFAPMTSNIPLRLINIEFDHKNDYSSNLA 982

  Fly   802 IVR------KRLQDLSWETLDFN 818
            :.|      |.::.|:.:|.:||
Yeast   983 VSRCFKSLSKLIEGLNEQTKNFN 1005

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10445	NP_649751.2	HepA	<113..919	CDD:440319	170/962 (18%)
		DEAD-like_helicase_N	209..534	CDD:475120	78/428 (18%)
IRC20	NP_013348.1	DEXQc_SHPRH	383..602	CDD:350828	70/336 (21%)
		RAD18	1234..>1327	CDD:227719
		RING-HC_IRC20-like	1234..1277	CDD:438497
		SF2_C_SNF	1356..1485	CDD:350180