DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10445 and RAD5

DIOPT Version :9

Sequence 1:	NP_001246974.1	Gene:	CG10445 / 40938	FlyBaseID:	FBgn0037531	Length:	945	Species:	Drosophila melanogaster
Sequence 2:	NP_013132.1	Gene:	RAD5 / 850719	SGDID:	S000004022	Length:	1169	Species:	Saccharomyces cerevisiae

Alignment Length:	1097	Identity:	256/1097 - (23%)
Similarity:	445/1097 - (40%)	Gaps:	364/1097 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 SSGEINNWMEPEPVDSLELSGEYADNE-----------------SAIFVSASEYNEKKAQIDQLV 77
            ||.||          |.|::..:.||:                 |.||       |::...:.|:
Yeast   255 SSHEI----------SFEVTLIFCDNKRLSIGDSFILQLDCFLTSLIF-------EERNDGESLM 302

  Fly    78 QKILTMEQQQRQLEENASETKELCDLKLHLEKLNARLEALGEFLDTLRLRE--DQQEI----KIE 136
            ::..|....:|: ::|.:..:.|.:....||..:.|| ||.:..|.|||:.  |:|:.    |||
Yeast   303 KRRRTEGGNKRE-KDNGNFGRTLTETDEELESRSKRL-ALLKLFDKLRLKPILDEQKALEKHKIE 365

  Fly   137 DNS--ELVDHTEQPKWSNLYSGLNRYRQKANHTAAQFYQHKSNIIDSLKTLYEPIQPRPAIDDL- 198
            .||  |::|.......||..:.::...:...|      :.::..::.|||.|:..|...::..|
Yeast   366 LNSDPEIIDLDNDEICSNQVTEVHNNLRDTQH------EEETMNLNQLKTFYKAAQSSESLKSLP 424

  Fly   199 EKQPA--LLLVRLLKHQQSCLKWMQFRERQ----------------------------------- 226
            |.:|:  :..:.|..:|:..|.||..||::
Yeast   425 ETEPSRDVFKLELRNYQKQGLTWMLRREQEFAKAASDGEASETGANMINPLWKQFKWPNDMSWAA 489

  Fly   227 ----------------------------------KISGGILADDMGLGKTLSMIALILASEETKN 257
                                              .|.||||:|:||||||::..:|:|:
Yeast   490 QNLQQDHVNVEDGIFFYANLHSGEFSLAKPILKTMIKGGILSDEMGLGKTVAAYSLVLS------ 548

  Fly   258 RKREEKKKALTLKWTQEFNRVYCKEIRKISMFDDEEESGKEEEQYEPPEKRTCHVKTKKINQFRI 322
                                  |..
Yeast   549 ----------------------CPH---------------------------------------- 551

  Fly   323 LDDDDNDAGDKAVVEDEQ---KDLLAKTPEPEVFSSDEEEEHLSNGRYPSANTLVVCPMSVMCQW 384
                |:|..||.:.:.|.   .|.|     |..:..:::.       |.|..||:|.|||::.||
Yeast   552 ----DSDVVDKKLFDIENTAVSDNL-----PSTWQDNKKP-------YASKTTLIVVPMSLLTQW 600

  Fly   385 AHEVASKVAQNAIRVLTFHGPNR-HEI----GIEAFRSY--------DLVITSYNLVVNELKRYG 436
            ::|...  |.|:        |:. ||:    .:.:.::.        .:|:|:|.:|.||..::.
Yeast   601 SNEFTK--ANNS--------PDMYHEVYYGGNVSSLKTLLTKTKTPPTVVLTTYGIVQNEWTKHS 655

  Fly   437 N----------TSPLFAVYWNRVILDEAHIIRNSKTNCCNSVCQLRAHCHWALTGTPVQNRGVDV 491
            .          :|.||:|.:.|:|:||.|.|||..|....:|..|:..|.|.|||||:.||..|:
Yeast   656 KGRMTDEDVNISSGLFSVNFYRIIIDEGHNIRNRTTVTSKAVMALQGKCKWVLTGTPIINRLDDL 720

  Fly   492 FALLRFVNVPNFQDLQQWK---------KNLNESMLGHRRLNFIIKPLMLRRTKQKLQASGDMPA 547
            ::|::|:.:..::.:..||         ||..::.   ..:|.|::|::||||||.....|..
Yeast   721 YSLVKFLELDPWRQINYWKTFVSTPFESKNYKQAF---DVVNAILEPVLLRRTKQMKDKDGKP-- 780

  Fly   548 LPSLKIELICVQLSKTEMAVYQILSAISKKIFTQFLLQREKGNSDLNYYSLERTPQFIAGHMSDE 612
                     .|:|...|:.:.::..:.|:.:..:|||.:.
Yeast   781 ---------LVELPPKEVVIKRLPFSKSQDLLYKFLLDKA------------------------- 811

  Fly   613 RYNEIYERFLKSLGYNPGEKILGIY--ILVLLLRLRQFCCHPGLMIGMLRGALTAEDVQNVKVDA 675
                  |..:|| |...|: :|..|  |||.:|||||.||||||:     |:....|....|.:.
Yeast   812 ------EVSVKS-GIARGD-LLKKYSTILVHILRLRQVCCHPGLI-----GSQDENDEDLSKNNK 863

  Fly   676 SDVEGQLKMDVLAEL--DKFDETDSED----------------------DC--CDEEDS------ 708
            ...|..:::|.|..:  ::||.:.|::                      :|  |..|..
Yeast   864 LVTEQTVELDSLMRVVSERFDNSFSKEELDAMIQRLKVKYPDNKSFQSLECSICTTEPMDLDKAL 928

  Fly   709 -TRRDGNFKLEVIKDEIKEENVPWDSGDDLPTASSFEDQLDSARALKLL----NPQNPIFQFIRP 768
             |....:|..:.:.:.|:.:|.. :.|...|..   .:|:|:.|.|.|:    |.:|..|:...|
Yeast   929 FTECGHSFCEKCLFEYIEFQNSK-NLGLKCPNC---RNQIDACRLLALVQTNSNSKNLEFKPYSP 989

  Fly   769 SAKLKMVIDKLEELL----TGTNDKIIVTSQWVSYLAIVRKRL-----QDLSWETLDFNGQLTAK 824
            ::|...:...|:||.    :...:::::.||:.:||.|:.|.|     :|:: :...|:|:|:.|
Yeast   990 ASKSSKITALLKELQLLQDSSAGEQVVIFSQFSTYLDILEKELTHTFSKDVA-KIYKFDGRLSLK 1053

  Fly   825 EREIVLRDFNAN--NEKRVLLLSLTAGGVGLNLNVANHMLIVDLHWNPQLERQAQDRIYRYGQTK 887
            ||..||.||...  :.:::|||||.||||||||..|:|..::|..|:|.:|.||.||::|.|||.
Yeast  1054 ERTSVLADFAVKDYSRQKILLLSLKAGGVGLNLTCASHAYMMDPWWSPSMEDQAIDRLHRIGQTN 1118

  Fly   888 PTFIYRYMCQDTVEQRIKSLQDCKLEIAKVVLPEEGGEVTKCVGGGLNLAELKKLFE 944
            ...:.|::.||::|:::..:|:.|..|.:.:..:|.....:      .:.|::.|||
Yeast  1119 SVKVMRFIIQDSIEEKMLRIQEKKRTIGEAMDTDEDERRKR------RIEEIQMLFE 1169

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10445	NP_001246974.1	HepA	<90..945	CDD:223627	241/1020 (24%)
CG10445	NP_001246974.1	DEAD-like_helicase_N	209..534	CDD:421690	87/428 (20%)
RAD5	NP_013132.1	HepA	116..1169	CDD:223627	254/1095 (23%)
RAD5	NP_013132.1	zf-C3HC4	914..960	CDD:306580	9/46 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	143	1.000	Domainoid score	I997
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000507
OrthoInspector	1	1.000	-	-		mtm9251
orthoMCL	1	0.900	-	-		OOG6_101296
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2250
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.840