Protein Alignment CG10445 and HIS4

DIOPT Version :9

• Sequence 1: NP_001246974.1
• Gene: CG10445 / 40938
• FlyBaseID: FBgn0037531
• Length: 945
• Species: Drosophila melanogaster
• Sequence 2: NP_009900.2
• Gene: HIS4 / 850327
• SGDID: S000000535
• Length: 799
• Species: Saccharomyces cerevisiae
• Alignment Length: 851
• Identity: 166/851 - (19%)
• Similarity: 277/851 - (32%)
• Gaps: 308/851 - (36%)

  Fly   193 PAIDDLEKQPALLLVRLLKHQQSCLKWMQFRERQKISGGILADDMGLGKTLSMIALILASEETKN 257
            |.||||                  ..|...:|...:.|.:|.|    |.:||       :||...
Yeast     7 PLIDDL------------------ASWNSKKEYVSLVGQVLLD----GSSLS-------NEEILQ 42

  Fly   258 RKREEKKKALTL-----KWTQEFNRVYCKEIRKI------SMFDDEEESGKEE---EQYEPPEKR 308
            ..:||:...:.|     |::.:       ||...      |:|...:::...|   ||...|::|
Yeast    43 FSKEEEVPLVALSLPSGKFSDD-------EIIAFLNNGVSSLFIASQDAKTAEHLVEQLNVPKER 100

  Fly   309 TCHVKTKKI--NQFRILDDDDNDAGDKAV-VEDEQKDLLAK-------TPEPE------------ 351
            .. |:...:  |||.:   ....:.||.| ::...||:|.|       |..|:
Yeast   101 VV-VEENGVFSNQFMV---KQKFSQDKIVSIKKLSKDMLTKEVLGEVRTDRPDGLYTTLVVDQYE 161

  Fly   352 -----VFSSDE---EEEHLSNGRY-------------PSANTLVVCPMSVMCQWAHEVASKVAQN 395
                 |:||.:   :...|..|.|             .|.|...:..:|..|. :..:...|.|.
Yeast   162 RCLGLVYSSKKSIAKAIDLGRGVYYSRSRNEIWIKGETSGNGQKLLQISTDCD-SDALKFIVEQE 225

  Fly   396 AI-----RVLTFHGPNRHE-IGIEAF---RSYDLVITSYNLVVNELKRYGNTSPLFAVYWNRVIL 451
            .:     ..::..|..:|. :|:|:.   |..|....||.      :|..|.|.|.    :..|.
Yeast   226 NVGFCHLETMSCFGEFKHGLVGLESLLKQRLQDAPEESYT------RRLFNDSALL----DAKIK 280

  Fly   452 DEAHIIRNSKTNCCNSVCQLRAHCHWALTGTPVQNRGVDVFALLRFVNVPNFQDLQQWKKNLNES 516
            :||..:..:|.         :....|         ...|:|.......|.|...|:..:.|||..
Yeast   281 EEAEELTEAKG---------KKELSW---------EAADLFYFALAKLVANDVSLKDVENNLNMK 327

  Fly   517 ML------GHRRLNFIIKPLMLRRTKQKLQASGDMPALPSLKIELICVQLSKTEMAVYQILS-AI 574
            .|      |..:..|:.:|   :..::||..          .|.|..|:.| .::.|.:.|| .|
Yeast   328 HLKVTRRKGDAKPKFVGQP---KAEEEKLTG----------PIHLDVVKAS-DKVGVQKALSRPI 378

  Fly   575 SKKIFTQFLLQ------REKGNSDLNYY------------------------------------S 597
            .|......|:.      |:||||.|..|                                    |
Yeast   379 QKTSEIMHLVNPIIENVRDKGNSALLEYTEKFDGVKLSNPVLNAPFPEEYFEGLTEEMKEALDLS 443

  Fly   598 LERTPQFIAGHMSDERYN-EIYERFLKSLGYNPGEKILGIYILVLLLRLRQFCCHPG-------- 653
            :|...:|.|..:..|... |.....|.|....|.||: |:||             ||
Yeast   444 IENVRKFHAAQLPTETLEVETQPGVLCSRFPRPIEKV-GLYI-------------PGGTAILPST 494

  Fly   654 -LMIGM------------------LRGALTAEDVQNV-KVDASDV------EGQLKM----DVLA 688
             ||:|:                  ..|.::.|.|... ||.||.:      :....|    :.:.
Yeast   495 ALMLGVPAQVAQCKEIVFASPPRKSDGKVSPEVVYVAEKVGASKIVLAGGAQAVAAMAYGTETIP 559

  Fly   689 ELDK--------------FDETDSEDDCCDEEDSTRRDGNFKLEVIKDEIKEENVPWDSGDDLPT 739
            ::||              :.:.|::..|..:..:    |..::.||.||  :.:|.:.:.|.|
Yeast   560 KVDKILGPGNQFVTAAKMYVQNDTQALCSIDMPA----GPSEVLVIADE--DADVDFVASDLL-- 616

  Fly   740 ASSFEDQLDSARALKLLNPQNPIFQFIRPSAKLKMVIDKLEELLTGTND------KIIVTSQWVS 798
             |..|..:||...|..:|                :...|::|:....::      ::.:..:.::
Yeast   617 -SQAEHGIDSQVILVGVN----------------LSEKKIQEIQDAVHNQALQLPRVDIVRKCIA 664

  Fly   799 YLAIVRKRLQDLSWETLDFNGQLTAKEREIVLRDFNAN-------NEKRVLLLSLTAGGVGLNLN 856
            :..||   |.|...|.|:.:.|...:  .::|:..|||       |...|.:.:.|....|...:
Yeast   665 HSTIV---LCDGYEEALEMSNQYAPE--HLILQIANANDYVKLVDNAGSVFVGAYTPESCGDYSS 724

  Fly   857 VANHML 862
            ..||.|
Yeast   725 GTNHTL 730

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10445	NP_001246974.1	HepA	<90..945	CDD:223627	166/851 (20%)
		DEAD-like_helicase_N	209..534	CDD:421690	77/396 (19%)
HIS4	NP_009900.2	PLN02346	140..341	CDD:215196	41/229 (18%)
		Histidinol_dh	374..788	CDD:395657	77/401 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0141
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900