DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10445 and EDA16

DIOPT Version :9

Sequence 1:	NP_001246974.1	Gene:	CG10445 / 40938	FlyBaseID:	FBgn0037531	Length:	945	Species:	Drosophila melanogaster
Sequence 2:	NP_176309.2	Gene:	EDA16 / 842407	AraportID:	AT1G61140	Length:	1280	Species:	Arabidopsis thaliana

Alignment Length:	1132	Identity:	287/1132 - (25%)
Similarity:	433/1132 - (38%)	Gaps:	364/1132 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 SDTTEIHKQSCSIQDQ------------------SSVP----VPDS---SGEINNW--------- 37
            ||....:..|||.||.                  ||||    |.|.   |||.|.|
plant   314 SDLDRPNNYSCSFQDNKTVHVKVKPEAESEKVVYSSVPGEFSVRDDAYLSGETNRWWSGASSSAV 378

  Fly    38 ------------MEPEPV----DSLELSG----------EYADNESAIFVSASEYNEKKAQIDQL 76
                        |.|:..    ||.::|.          :|...:.:.....:||  |..||.|.
plant   379 SYQTDIEKGYSYMAPQTALPSQDSGKISSNHFYDSDTCLQYVVEDPSPVTQNNEY--KDFQIQQG 441

  Fly    77 VQKILTMEQQQRQLEENASETKELCDLKLHLEKLNARLEAL-GEFLDTLRLREDQQEIKIED--N 138
            .::.:    |.|.::...|               ||..|:: ....:.:...:|..::.|.:  .
plant   442 DREYI----QPRGIDSQFS---------------NASFESVQSHSSECISDSDDDSDVCIIEPYG 487

  Fly   139 SELVDH----TEQPKWSNLYSGLNRYRQKANHTAAQFYQHKSNII--DSLKTLYEP----IQPRP 193
            ...:.|    .:.|..|:.||.::....::.....|  .:|.|:|  .:|:.|.:|    |.|
plant   488 QSAIPHRPLAMKMPVVSSEYSTVSHNFNQSGGLKLQ--SNKENMIFQAALQDLTQPNSEAILP-- 548

  Fly   194 AIDDLEKQPALLLVRLLKHQQSCLKWMQFRERQ--KISGGILADDMGLGKTLSMIALILASEETK 256
                    ..:|.|.||:||:..|.||..:|..  ..||||||||.|||||:|.|||||
plant   549 --------DGVLTVPLLRHQRIALSWMAQKETSGFPCSGGILADDQGLGKTVSTIALIL------ 599

  Fly   257 NRKREEKKKALTLKWTQEFNRVYCKEIRKISMFDDEEESGKEEEQYEP--PEKRTCHVKTKKINQ 319
               :|..|.|..           |:|..|..:||.|.|:|    :..|  |..|:.|     ...
plant   600 ---KERSKPAQA-----------CEESTKKEIFDLESETG----ECAPLKPSGRSKH-----FEH 641

  Fly   320 FRILDDDDNDAGDKAVVEDEQKDLLAKTPEPEVFSSDEEEEHLSNGRYPSANTLVVCPMSVMCQW 384
            .::|.:::...||.          :.|.                .|| |:|.||||||.|||.||
plant   642 SQLLSNENKVGGDS----------VGKV----------------TGR-PAAGTLVVCPTSVMRQW 679

  Fly   385 AHEVASKVAQNA-IRVLTFHGPNR----HEIGIEAFRSYDLVITSYNLVVNEL------------ 432
            |.|:..||...| :.||.:||.:|    ||:.     .||:|:|::::|..|:
plant   680 ADELHKKVTSEANLSVLVYHGSSRTKDPHELA-----KYDVVVTTFSIVSMEVPKQPLVDDEDEE 739

  Fly   433 --------------------------KRYGN--------TSPLFAVYWNRVILDEAHIIRNSKTN 463
                                      |:.|:        :.||..|.|.||:||||..|:|.||.
plant   740 KDGVHDGGTAATGFCSNKKRKYPPDSKKKGSKKKKVEFLSGPLAKVSWFRVVLDEAQSIKNYKTQ 804

  Fly   464 CCNSVCQLRAHCHWALTGTPVQNRGVDVFALLRFVNVPNFQDLQQWKKNLNESML-----GHRRL 523
            ...:...|||...|.|:|||:||...|:::..||:....:.....:...:...:.     |:::|
plant   805 VARACWGLRAKRRWCLSGTPIQNSIDDLYSYFRFLKYDPYSSYVLFCSTIKNPITRNPVKGYQKL 869

  Fly   524 NFIIKPLMLRRTKQKLQASGDMPALPSLKIELICVQLSKTEMAVYQILSAISKKIFTQFLLQREK 588
            ..|:|.:||||||..|.....:.:||...|||..|..:..|...|..|.|.|:   |||....|.
plant   870 QAILKTVMLRRTKGSLLDGKPIISLPPKSIELRKVDFTVEERDFYSKLEAESR---TQFREYAEA 931

  Fly   589 GNSDLNYYSLERTPQFIAGHMSDERYNEIYERFLKSLGYNPGEKILGIYILVLLLRLRQFCCHPG 653
            |....||                                        :.||::||||||.|.||.
plant   932 GTVKQNY----------------------------------------VNILLMLLRLRQACDHPL 956

  Fly   654 LM-----------IGMLRGALTA--------------EDVQ------------------------ 669
            |:           :|:.:..:.:              ||..
plant   957 LVNGEYSFTWESSVGLAKKQIQSDASLAICGICNDAPEDAVASVCGHVFCKQCIYERLTGDSNHC 1021

  Fly   670 -----NVKVDASDVEGQLKM-DVLAELDKFDETDSEDDCCDEEDSTRRDGNFK--LEVIKDEIKE 726
                 ||::..|.:..:.:: |.:.::.:...::|...|.| ||........|  ||:::
plant  1022 PFANCNVRLTISSLSSKTRLDDAMPDMQERATSNSLSPCSD-EDLPYGSSKIKAALEILQ----- 1080

  Fly   727 ENVPWDSGDDLPTASSFED--QLDSARALKLLNPQNPIFQFIRPSAKLKMVIDKLEELLTGTNDK 789
                     .||.|....|  |:...|....|:        |.|.....|.:|...::   ..:|
plant  1081 ---------SLPKAHDLTDSNQISENREYSGLS--------ITPVKNEGMSVDVPIKV---AGEK 1125

  Fly   790 IIVTSQWVSYLAIVRKRL--QDLSWETLDFNGQLTAKEREIVLRDFNANNEKRVLLLSLTAGGVG 852
            .||.|||...|.::...|  ..:.:..||  |.::...|:..::|||...|..|:::||.|..:|
plant  1126 AIVFSQWTKMLNLLEASLVSSHIQYRRLD--GTMSVAARDKAVQDFNTLPEVTVMIMSLKAASLG 1188

  Fly   853 LNLNVANHMLIVDLHWNPQLERQAQDRIYRYGQTKPTFIYRYMCQDTVEQRIKSLQDCK-LEIAK 916
            ||:..|.|:|::||.|||..|.||.||.:|.|||:|..:.|:..:||||.||.:||..| :.:|.
plant  1189 LNMVAACHVLMLDLWWNPTTEDQAIDRAHRIGQTRPVTVVRFTVKDTVEDRILALQQKKRMMVAS 1253

  Fly   917 VVLPEEGGEVTKCVGGGLNLAELKKLF 943
            ....:|.|...    ..|.:.:|..||
plant  1254 AFGEDEKGSRQ----SHLTVEDLSYLF 1276

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10445	NP_001246974.1	HepA	<90..945	CDD:223627	255/989 (26%)
CG10445	NP_001246974.1	DEAD-like_helicase_N	209..534	CDD:421690	114/384 (30%)
EDA16	NP_176309.2	SNF2_N	559..958	CDD:278600	146/502 (29%)
		zf-C3HC4_2	986..1023	CDD:290634	2/36 (6%)
		Helicase_C	1124..1220	CDD:278689	37/97 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	180	1.000	Domainoid score	I1043
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D132523at2759
OrthoFinder	1	1.000	-	-		FOG0000507
OrthoInspector	1	1.000	-	-		mtm1031
orthoMCL	1	0.900	-	-		OOG6_101296
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1278
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.820