DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10445 and AT5G43530

DIOPT Version :9

Sequence 1:	NP_001246974.1	Gene:	CG10445 / 40938	FlyBaseID:	FBgn0037531	Length:	945	Species:	Drosophila melanogaster
Sequence 2:	NP_199166.1	Gene:	AT5G43530 / 834373	AraportID:	AT5G43530	Length:	1277	Species:	Arabidopsis thaliana

Alignment Length:	1164	Identity:	270/1164 - (23%)
Similarity:	438/1164 - (37%)	Gaps:	391/1164 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SSSPSDTTEIHKQSCSIQDQSSV--------PVP---------------DSSGEIN-NWMEPEPV 43
            ||..||.|...::...::..:.|        |.|               |...|.: ..::.|||
plant   281 SSGDSDGTSAKRRKMEMESYAPVGVESCILAPTPLRVVKPEKLDTPEVIDLESEKSYTHVKMEPV 345

  Fly    44 DSLELSG----------EYADNESAIFVSASEYNEKKAQIDQ----------LVQKIL---TMEQ 85
            :.:::..          :::..:.:::|.......:|.:::.          ||.:.|   |...
plant   346 EEIKVEAVKMSSQVEDVKFSREQKSVYVKKEPVGARKVKVEDGDFPVEKDWYLVGRSLVTATSTS 410

  Fly    86 QQRQLEEN-------------------ASETKELCDL-KLHLE--------------KLNARLEA 116
            :.|:||:|                   ...||...:: :|.:|              |:..|..|
plant   411 KGRKLEDNEIVNFTFSSVAKWKVPNIVRFSTKRCGEIGRLPMEWSNWAVSLLRSGKVKMLGRCVA 475

  Fly   117 LGEFLDTLRLREDQQEIKIEDNSELVDHTEQPKW-----SNLYSGLNRYRQKANHTAAQFYQHKS 176
            ...||  ..::|....:....:|.:.....:..|     .||.|.|:...|...|...:.||...
plant   476 APPFL--TMMQEIMLYVSFYIHSSIFTDVSKSTWRIGSSPNLESTLHPLLQLFKHLTIKPYQKAE 538

  Fly   177 NIIDSLKT------LYEPIQPRPAIDDLEKQ---------------------------------- 201
            ...:.|.:      |.:....|.|:..:.|:
plant   539 FTPEELNSRKRSLNLEDDYDERAALLAIAKRRKGCQQSLEQNKDEEEAPESYMNRVVGAADSYNL 603

  Fly   202 -----PALLLVRLLKHQQSCLKWMQFRER------------------------------------ 225
                 |:.|...|..:|:..|.||...|:
plant   604 EEMEAPSTLTCNLRPYQKQALYWMSESEKGIDVEKAAETLHPCWEAYRICDERAPSIYLNIFSGE 668

  Fly   226 ---------QKISGGILADDMGLGKTLSMIALILASEETKNRKREEKKKALTLKWTQEFNRVYCK 281
                     |...||||||.||||||:..||||||.....|.:.|:
plant   669 ATIQFPTATQMARGGILADAMGLGKTVMTIALILARPGRGNPENED------------------- 714

  Fly   282 EIRKISMFDDEEESGKEEEQYEPPEKRTCHVKTKKINQFRILDDDDNDAGDKAVVEDEQKDLLAK 346
                                                                .:|.|...|
plant   715 ----------------------------------------------------VLVADVNAD---- 723

  Fly   347 TPEPEVFSSDEEEEHLSNGRYPS-ANTLVVCPMSVMCQWAHEVASKVAQNAIRVLTFHGPNR-HE 409
                   ..:.:|.|::.....: ..||::|||:::.||..|:.:....:.:.||.::|.:| |:
plant   724 -------KRNRKEIHMALTTVKAKGGTLIICPMALLSQWKDELETHSKPDTVSVLVYYGGDRTHD 781

  Fly   410 IGIEAFRSYDLVITSYNLVVNELKRYGNTSPLFAVYWNRVILDEAHIIRNSKTNCCNSVCQLRAH 474
              .:|..|:|:|:|:|.::.:..|:....|....:.|.|::|||||.|::.||....:..:|.:|
plant   782 --AKAIASHDVVLTTYGVLTSAYKQDMANSIFHRIDWYRIVLDEAHTIKSWKTQAAKATFELSSH 844

  Fly   475 CHWALTGTPVQNRGVDVFALLRFVNVPNFQDLQQWKKNL-----NESMLGHRRLNFIIKPLMLRR 534
            |.|.|||||:||:..|:::||.|::|..:.:...|.|.:     |....|.:.:..|::||||||
plant   845 CRWCLTGTPLQNKLEDLYSLLCFLHVEPWCNWAWWSKLIQKPYENGDPRGLKLIKAILRPLMLRR 909

  Fly   535 TKQKLQASGDM-PALPSLKIELICVQLSKTEMAVYQILSAISKKIFTQFLLQREKGNSDLNYYSL 598
            ||:.....|.: ..||...:::|..:.|:.|...|..|...||..|.||:.|
plant   910 TKETRDKEGSLILELPPTDVQVIECEQSEAERDFYTALFKRSKVQFDQFVAQ------------- 961

  Fly   599 ERTPQFIAGHMSDERYNEIYERFLKSLGYNPGEKILGIY--ILVLLLRLRQFCCHPGLMIGMLRG 661
                                            .|:|..|  ||.|||||||.|.||.|:
plant   962 --------------------------------GKVLHNYANILELLLRLRQCCNHPFLV------ 988

  Fly   662 ALTAEDVQNVKVDASDVEGQLKMDVLAELDKFDETDSEDDCCDEEDSTR----------RDGNFK 716
                       :..:|.:....:|.||.  :|  .|:..|...:...:|          ||||
plant   989 -----------MSRADSQQYADLDSLAR--RF--LDNNPDSVSQNAPSRAYIEEVIQDLRDGN-- 1036

  Fly   717 LEVIKDEIKEENVPWDSGDD---LPTASSF--EDQLDSARA---------------LKLLN-PQN 760
                   .||..:..:|.||   .|.|...  |..|.|.|:               .:|:: |.:
plant  1037 -------SKECPICLESADDPVLTPCAHRMCRECLLTSWRSPSCGLCPICRTILKRTELISCPTD 1094

  Fly   761 PIFQF-----IRPSAKLKMVIDKLEEL-LTGTNDKIIVTSQWVSYLAIVRKRLQDLSWETLDFNG 819
            .||:.     .:.|:|:..::..||:: .:|:.:|.||.|||.|:|.::...|:...:|.|.|:|
plant  1095 SIFRVDVVKNWKESSKVSELLKCLEKIKKSGSGEKSIVFSQWTSFLDLLEIPLRRRGFEFLRFDG 1159

  Fly   820 QLTAKEREIVLRDFNANNEKRVLLLSLTAGGVGLNLNVANHMLIVDLHWNPQLERQAQDRIYRYG 884
            :|..|.||.||::||...:|.:||:||.||||||||..|:.:.::|..|||.:|.||..||:|.|
plant  1160 KLAQKGREKVLKEFNETKQKTILLMSLKAGGVGLNLTAASSVFLMDPWWNPAVEEQAIMRIHRIG 1224

  Fly   885 QTKPTFIYRYMCQDTVEQRIKSLQDCKLEIAKVVLPEEGGEVTKCVGGGLNLAELKKLF 943
            |.:..|:.|::.:||||:|::.:|..|..:....|.:|  ||...     .|.|||.||
plant  1225 QKRTVFVRRFIVKDTVEERMQQVQARKQRMIAGALTDE--EVRSA-----RLEELKMLF 1276

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10445	NP_001246974.1	HepA	<90..945	CDD:223627	250/1030 (24%)
CG10445	NP_001246974.1	DEAD-like_helicase_N	209..534	CDD:421690	88/376 (23%)
AT5G43530	NP_199166.1	HIRAN	402..490	CDD:214906	16/89 (18%)
		SNF2_N	680..988	CDD:278600	114/436 (26%)
		DEXDc	681..853	CDD:238005	63/255 (25%)
		RING	1039..1083	CDD:238093	10/43 (23%)
		Helicase_C	1112..1224	CDD:278689	48/111 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	180	1.000	Domainoid score	I1043
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D132523at2759
OrthoFinder	1	1.000	-	-		FOG0000507
OrthoInspector	1	1.000	-	-		mtm1031
orthoMCL	1	0.900	-	-		OOG6_101296
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1278
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.820