Protein Alignment CG10445 and CHD9

DIOPT Version :10

• Sequence 1: NP_649751.2
• Gene: CG10445 / 40938
• FlyBaseID: FBgn0037531
• Length: 945
• Species: Drosophila melanogaster
• Sequence 2: XP_005256225.1
• Gene: CHD9 / 80205
• HGNCID: 25701
• Length: 2898
• Species: Homo sapiens
• Alignment Length: 1066
• Identity: 226/1066 - (21%)
• Similarity: 396/1066 - (37%)
• Gaps: 330/1066 - (30%)

  Fly     3 SSSPSD---------TTEIH-----KQSCSIQDQS-----------SVPVPDSSGEIN--NWMEP 40
            ||..||         .|::.     ||...::.:|           ::......||.|  ..|.|
Human   487 SSKKSDGSGTYTKLQNTQVRVMSEKKQRKKVESESKQEKANRIISEAIAKAKERGERNIPRVMSP 551

  Fly    41 EPVDSLELSGEYADNESAIFVSASEYNEKKAQIDQLVQKILTMEQQQRQLEENASETKELCDLKL 105
            |...:..:.|:               .|||.:           ..:.:..::::.:||....||
Human   552 ENFPTASVEGK---------------EEKKGR-----------RMKSKPKDKDSKKTKTCSKLK- 589

  Fly   106 HLEKLNARLEALGEFLDTL---RLREDQQEIKIEDNSELVDHTEQPKWSNLYSGLNRYRQKANHT 167
              ||..     :|:.:.||   :.|:::...:|.|..::..||.:.:.|.......:.::|....
Human   590 --EKTK-----IGKLIITLGKKQKRKNESSDEISDAEQMPQHTLKDQDSQKRRSNRQIKRKKYAE 647

  Fly   168 AAQFYQHKSNIIDSLKTLYEPIQPRPAIDDLEKQPALLLVRLLKHQQSCL--KWMQFRE-RQKIS 229
            ..:..|.:..:..|:| :.:...|.|.     :||..|.|.....:.:.:  |.:..|. :::||
Human   648 DIEGKQSEEEVKGSMK-IKKNSAPLPG-----EQPLQLFVENPSEEDAAIVDKILSSRTVKKEIS 706

  Fly   230 GGILADDMGL---GKTLSMIALILASEE--TKNRKREEKKKALTLKWTQE-----------FNRV 278
            .|::.|....   .|..|.:....|:||  .|:::.::|.|...|:..|.           ||..
Human   707 PGVMIDTEEFFVKYKNYSYLHCEWATEEQLLKDKRIQQKIKRFKLRQAQRAHFFADMEEEPFNPD 771

  Fly   279 YCKEIRKISM-FDDEEESGKEEEQY------EPPEKRTCHVK----TKKINQF----------RI 322
            |.:..|.:.: |.:::::|:....|      .|.|..|..:|    ..||.:|          |.
Human   772 YVEVDRVLEVSFCEDKDTGEPVIYYLVKWCSLPYEDSTWELKEDVDLAKIEEFEQLQASRPDTRR 836

  Fly   323 LDDDDNDAGDKAVVEDEQKDL----------------------------------LAKTPEPEVF 353
            ||...::...|.   |:.:|.                                  |.||.:...|
Human   837 LDRPPSNIWKKI---DQSRDYKNGNQLREYQLEGLNWLLFNWYNRRNCILADEMGLGKTIQSITF 898

  Fly   354 SSDEEEEHLSNGRYPSANTLVVCPMSVMCQWAHEVASKVAQNAIRVLTFHGP-------NRHEIG 411
            .   .|..|:..|.|   .|::.|:|.:..|..|..:   ...|.|:.:||.       .::|:.
Human   899 L---YEILLTGIRGP---FLIIAPLSTIANWEREFRT---WTDINVVVYHGSLISRQMIQQYEMY 954

  Fly   412 IE---------AFRSYDLVITSYNLVVNELKRYGNTSPLFAVYWNRVILDEAHIIRNSKTNCCNS 467
            ..         |:| :..:||::.:::      |....|.|:.|..||:||||.::|........
Human   955 FRDSQGRIIRGAYR-FQAIITTFEMIL------GGCGELNAIEWRCVIIDEAHRLKNKNCKLLEG 1012

  Fly   468 VCQLRAHCHWALTGTPVQNRGVDVFALLRFVNVPNFQD----LQQWKKNLNESMLGHRRLNFIIK 528
            :..:.......|||||:||...::|:||.|:....|..    :|::.....|..:  ::|..|:|
Human  1013 LKLMNLEHKVLLTGTPLQNTVEELFSLLHFLEPLRFPSESTFMQEFGDLKTEEQV--QKLQAILK 1075

  Fly   529 PLMLRRTKQKLQASGDMPALPSLKIELICVQLSKTEMAVYQILSAISKKIFTQFLLQREKGNSDL 593
            |:||||.|:.::..     |...:..:|.|:|:..:...|:   ||.:|.|: ||   .||....
Human  1076 PMMLRRLKEDVEKK-----LAPKEETIIEVELTNIQKKYYR---AILEKNFS-FL---SKGAGQT 1128

  Fly   594 NYYSLERTPQFIAGHMSDERYNEIYERFLKSLGYNPGEKILGIYILVLLLRLRQFCCHPGLMIGM 658
            |..:|..|                                        ::.||:.|.||.|:.|
Human  1129 NVPNLVNT----------------------------------------MMELRKCCNHPYLIKG- 1152

  Fly   659 LRGALTAEDVQNVKVDASDVEGQLKMDVLAELDKFDETDSEDDCCDEEDSTRRDGNFKLEVIKDE 723
                  ||:    |:                |.:|.:|.:
Human  1153 ------AEE----KI----------------LGEFRDTYN------------------------- 1166

  Fly   724 IKEENVPWDSGDDLPTASSFEDQLDSARALKLLNPQNPIFQFIRPSAKLKMVIDKLEELLTGTND 788
                          |.||.|..|                 ..|:.:.|| ::||||...:.....
Human  1167 --------------PAASDFHLQ-----------------AMIQSAGKL-VLIDKLLPKMKAGGH 1199

  Fly   789 KIIVTSQWVSYLAIVRKRL--QDLSWETLDFNGQLTAKEREIVLRDFN-ANNEKRVLLLSLTAGG 850
            |:::.||.|..|.|:...|  :...:|.:|  |::....|:..:..|: .::::.|.||...|||
Human  1200 KVLIFSQMVRCLDILEDYLIHKRYLYERID--GRVRGNLRQAAIDRFSKPDSDRFVFLLCTRAGG 1262

  Fly   851 VGLNLNVANHMLIVDLHWNPQLERQAQDRIYRYGQTKPTFIYRYMCQDTVEQRIKSLQDCKLEIA 915
            :|:||..|:..:|.|..||||.:.|||.|.:|.||.|...:||.:.:::.|:.:......||.:.
Human  1263 LGINLTAADTCIIFDSDWNPQNDLQAQARCHRIGQNKAVKVYRLVTRNSYEREMFDRASLKLGLD 1327

  Fly   916 KVVLPEEGGEVTKCVGGGLNLAELKK 941
            |.||....|..:. |||   :.:|.|
Human  1328 KAVLQSMSGRESN-VGG---IQQLSK 1349

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10445	NP_649751.2	HepA	<113..919	CDD:440319	194/905 (21%)
		DEAD-like_helicase_N	209..534	CDD:475120	89/418 (21%)
CHD9	XP_005256225.1	GAT1	161..558	CDD:227928	14/70 (20%)
		ROM1	176..>362	CDD:227709
		CD1_tandem_CHD5-9_like	686..750	CDD:349315	14/63 (22%)
		CD2_tandem_CHD5-9_like	770..828	CDD:349310	12/57 (21%)
		PLN03142	811..>1480	CDD:215601	157/702 (22%)
		BRK	2483..2532	CDD:197800
		BRK	2557..2601	CDD:197800