DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10445 and Ttf2

DIOPT Version :9

Sequence 1:	NP_001246974.1	Gene:	CG10445 / 40938	FlyBaseID:	FBgn0037531	Length:	945	Species:	Drosophila melanogaster
Sequence 2:	XP_036019252.1	Gene:	Ttf2 / 74044	MGIID:	1921294	Length:	1155	Species:	Mus musculus

Alignment Length:	1012	Identity:	281/1012 - (27%)
Similarity:	448/1012 - (44%)	Gaps:	263/1012 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 HKQSCSIQDQSSVPVPDSSGE---INNWMEPEPVDSLELSGEYADNESAIFVSASEYNEKKAQID 74
            |..:.|.:|.....|....|.   .::.::.:...||:.|.:....:   ..:||..::|....|
Mouse   324 HHATSSSEDSEDDGVSSRPGSPLLFDSTVDSQKKGSLQHSDQSVQRQ---MPAASGVSKKGDSSD 385

  Fly    75 QLVQKI-LTMEQQQRQLEENASETKELCDLKLHLEKLNARLEALGEFLDTLRLREDQQEIKIEDN 138
            ...|:. ||.:.:|::....|...:.|.|..   |||..:::||.:.|..|.|..:|       .
Mouse   386 PAAQRANLTTQLKQKKGTLAAVNIQALPDKG---EKLLKQIQALEDALSALALSPEQ-------G 440

  Fly   139 SELVDHTEQPKWSNLYS-------------------------GLNRYRQKANHTAAQF------- 171
            ::.....::|:.||:..                         ||...||:....|:|.
Mouse   441 TKEKCSAQEPEQSNITKAAAAPLHLVPPQPLPRPLIQPASSLGLKAGRQETPEGASQCSGEGWPG 505

  Fly   172 ----------------YQHKSNI----IDSLKTLYEPIQPRPAIDDLEKQPALLLVRLLKHQQSC 216
                            ..|..|:    .:::..|:..::..|....:.:.||.|.|.||.||:..
Mouse   506 TCCMDQVGLQALGHMNQHHLYNVWKITSEAIDELHRSLKSCPGETAVAEDPAGLKVPLLLHQKQA 570

  Fly   217 LKWMQFRERQKISGGILADDMGLGKTLSMIALILASEETKNRKREEKKKALTLKWTQEFNRVYCK 281
            |.|:.:||.||..||||||||||||||:||||||..:..:..|.:|:.:.:|  |..:
Mouse   571 LAWLLWRESQKPQGGILADDMGLGKTLTMIALILTKKNQQKSKEKERSEPVT--WLSK------- 626

  Fly   282 EIRKISMFDDEEESGKEEEQYEPPEKRTCHVKTKKINQFRILDDDDNDAGDKAVVEDEQKDLLAK 346
                                                          ||:
Mouse   627 ----------------------------------------------NDS---------------- 629

  Fly   347 TPEPEVFSSDEEEEHLSNGRYPSANTLVVCPMSVMCQWAHEVASKVAQNAIRVLTFHGPNRHEIG 411
                .||:              |:.||:|||.|::..|.:||..:|..|.:|:..:|||||.. .
Mouse   630 ----SVFT--------------SSGTLIVCPASLIHHWKNEVEKRVTSNRLRIYLYHGPNRSR-H 675

  Fly   412 IEAFRSYDLVITSYNLVVNE--------------LKRYGNTSPLFAVYWNRVILDEAHIIRNSKT 462
            .:...:||:|||:|:|:..|              |...|.::||..|.|.|:||||||.::|.:.
Mouse   676 AKVLSTYDIVITTYSLLAKEIPTTKQEGEVPGANLSVEGTSAPLLQVVWARIILDEAHNVKNPRV 740

  Fly   463 NCCNSVCQLRAHCHWALTGTPVQNRGVDVFALLRFVNVPNFQDLQQWKKNL-NESMLGHRRLNFI 526
            ....:||:|:|...||:||||:||..:|:::|::|:....|.:...||..: |.||.|..||:.:
Mouse   741 QTSIAVCKLQAQARWAVTGTPIQNNLLDMYSLMKFLRCSPFDEFSLWKSQVDNGSMKGGERLSIL 805

  Fly   527 IKPLMLRRTKQKLQASG-DMPALPSLKIELICVQLSKTEMAVYQILSAISKKIFTQFLLQREKGN 590
            .|.|:|||||.:|.::| .:.|||:.:.:|..::||:.|.|||.|..|.|:... |..|:|::|.
Mouse   806 TKSLLLRRTKDQLDSTGKPLVALPARRCQLHRLKLSEDERAVYDIFLARSRSAL-QSYLKRQEGR 869

  Fly   591 SDLNYYSLERTPQFIAGHMSDERYNEIYERFLKSLGYN----PGEKILGIYILVLLLRLRQFCCH 651
            ...:            |...|..::.:.:.|..|:...    ..::...:::|..||||||.|||
Mouse   870 GSHH------------GRSPDNPFSRVAQEFGSSVSQGCPAADSQRPSTVHVLSQLLRLRQCCCH 922

  Fly   652 PGLMIGMLRGALTAEDVQNVKVDASDVEGQLKMDVLAELDKFD--ETDSEDDCCDEEDSTRRDGN 714
                :.:|:.||...::::..:..| :|.||....|:::|..:  .|.|.:..|
Mouse   923 ----LSLLKSALDPTELESEGLVLS-LEEQLSALTLSKVDVSEPSPTVSLNGTC----------- 971

  Fly   715 FKLEVIKDEIKEENVPWDSGDDLPTASSFEDQLDSARALKLLNPQNPIFQFIRPSAKLKMVIDKL 779
            ||.|:..|                                           .|.|.|:..::.:|
Mouse   972 FKAELFDD-------------------------------------------TRRSTKVSSLLAEL 993

  Fly   780 EELLTGT-NDKIIVTSQWVSYLAIVRKRLQD--LSWETLDFNGQLTAKEREIVLRDFNANNEKRV 841
            |.:..|. :.|.::.|||.|.|.:|...|:.  |::.|:|  |.:..|:|..::..||.:...:|
Mouse   994 EAIQKGPGSQKSVIVSQWTSMLQVVALHLKKNRLTYATID--GSVNPKQRMDLVEAFNHSQGPQV 1056

  Fly   842 LLLSLTAGGVGLNLNVANHMLIVDLHWNPQLERQAQDRIYRYGQTKPTFIYRYMCQDTVEQRIKS 906
            :|:||.||||||||...||:.::|:||||.||.||.|||||.||.|...|:|::|:.|||::|..
Mouse  1057 MLISLLAGGVGLNLTGGNHLFLLDMHWNPSLEDQACDRIYRVGQKKDVVIHRFVCEGTVEEKILQ 1121

  Fly   907 LQDCKLEIAKVVLPEEGGEVTKCVGGGLNLAELKKLF 943
            ||:.|.::||.||....|.|||     |.||:||.||
Mouse  1122 LQEKKKDLAKQVLSGSEGPVTK-----LTLADLKILF 1153

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10445	NP_001246974.1	HepA	<90..945	CDD:223627	265/931 (28%)
CG10445	NP_001246974.1	DEAD-like_helicase_N	209..534	CDD:421690	105/339 (31%)
Ttf2	XP_036019252.1	zf-GRF	4..44	CDD:399670
		DEXHc_TTF2	563..813	CDD:350830	105/339 (31%)
		HepA	<566..1153	CDD:223627	232/755 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	254	1.000	Domainoid score	I2051
eggNOG	1	0.900	-	-		E1_COG0141
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D132523at2759
OrthoFinder	1	1.000	-	-		FOG0000507
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45626
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2250
SonicParanoid	1	1.000	-	-		X1278
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.910