DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10445 and HLTF

DIOPT Version :9

Sequence 1:	NP_001246974.1	Gene:	CG10445 / 40938	FlyBaseID:	FBgn0037531	Length:	945	Species:	Drosophila melanogaster
Sequence 2:	XP_011511393.1	Gene:	HLTF / 6596	HGNCID:	11099	Length:	1013	Species:	Homo sapiens

Alignment Length:	1050	Identity:	256/1050 - (24%)
Similarity:	407/1050 - (38%)	Gaps:	290/1050 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 HKQSCSIQDQSSVPVPDSSGEINNWMEPEPVDSL--ELSGEYA---DNESAIFVSASEYNEKKAQ 72
            :.:..::|...:.|...::.::|| :....|..|  ||:|..|   ||             |.||
Human    79 NNEMVALQRDPNNPYDKNAIKVNN-VNGNQVGHLKKELAGALAYIMDN-------------KLAQ 129

  Fly    73 IDQLV----QKILTMEQQQR--QLEENASETKELCDLKLHLEKLNARLEALGEFLDTLRLREDQQ 131
            |:.:|    ....||.....  ..|||.....:  .||.|..||....:.||
Human   130 IEGVVPFGANNAFTMPLHMTFWGKEENRKAVSD--QLKKHGFKLGPAPKTLG------------- 179

  Fly   132 EIKIEDNSELVDHTEQPKWSNLYSGLNRYRQKAN-----HTAAQFYQHKSNIIDSLKTLYEPIQP 191
                               .||.||....|...:     |.|.|.      ..:.|||.::.:
Human   180 -------------------FNLESGWGSGRAGPSYSMPVHAAVQM------TTEQLKTEFDKL-- 217

  Fly   192 RPAIDDL-------EKQPA-LLLVRLLKHQQSCLKWMQFRERQK--------------------- 227
               .:||       |.:|| .:...||.||:..|.||..||..|
Human   218 ---FEDLKEDDKTHEMEPAEAIETPLLPHQKQALAWMVSRENSKELPPFWEQRNDLYYNTITNFS 279

  Fly   228 -------ISGGILADDMGLGKTLSMIALILAS---------EETKNR--KRE------------- 261
                   :.||||||||||||||:.||:||.:         |..|..  |:|
Human   280 EKDRPENVHGGILADDMGLGKTLTAIAVILTNFHDGRPLPIERVKKNLLKKEYNVNDDSMKLGGN 344

  Fly   262 ---EKKKALTLKWTQEFNRVYCKEIRKISMFDDEEESG------KEEEQY----EPPEKRTCHVK 313
               ||...|:...::...:....:|::.|.|...|.|.      |...||    :..|..|..:.
Human   345 NTSEKADGLSKDASRCSEQPSISDIKEKSKFRMSELSSSRPKRRKTAVQYIESSDSEEIETSELP 409

  Fly   314 TKKINQFRILDDDDN---DAGDKAVVED-------------EQKDLLAK-TPEPEVFSSDEEEEH 361
            .|...:.:.:..:..   .||...|:||             .:|.:|.| ....|.....:.||.
Human   410 QKMKGKLKNVQSETKGRAKAGSSKVIEDVAFACALTSSVPTTKKKMLKKGACAVEGSKKTDVEER 474

  Fly   362 LSNGRYPSANTLVVCPMSVMCQWAHEVASKVAQNA-IRVLTFHGPNRHEIGIEAFRS-YDLVITS 424
                   ...||::||:||:..|..:....:..:. :....::||:|  |...|..| .|:|:|:
Human   475 -------PRTTLIICPLSVLSNWIDQFGQHIKSDVHLNFYVYYGPDR--IREPALLSKQDIVLTT 530

  Fly   425 YNLVVNELKRYGNTSPLFAVYWNRVILDEAHIIRNSKTNCCNSVCQLRAHCHWALTGTPVQNRGV 489
            ||::.::....|: |||.::.|.||||||.|.|||.......:|..|.:...|.|||||:||...
Human   531 YNILTHDYGTKGD-SPLHSIRWLRVILDEGHAIRNPNAQQTKAVLDLESERRWVLTGTPIQNSLK 594

  Fly   490 DVFALLRFVNVPNFQDLQQWKKNLNESML-----GHRRLNFIIKPLMLRRTKQKLQASGDMPALP 549
            |:::||.|:.:..|.|.:.|.:.:...:.     |.|||..:||.:.|||||........:..||
Human   595 DLWSLLSFLKLKPFIDREWWHRTIQRPVTMGDEGGLRRLQSLIKNITLRRTKTSKIKGKPVLELP 659

  Fly   550 SLKIELICVQLSKTEMAVYQILSAISKKIFTQFLLQREKGNSDLNYYSLERTPQFIAGHMSDERY 614
            ..|:.:..:.||..|..:||.:              :.:|.:.:..|..|.|   :..|.:|
Human   660 ERKVFIQHITLSDEERKIYQSV--------------KNEGRATIGRYFNEGT---VLAHYAD--- 704

  Fly   615 NEIYERFLKSLGYNPGEKILGIYILVLLLRLRQFCCHPGLMIGMLRGALTAEDVQNVKVDASDVE 679
                                   :|.|||||||.|||..|    |..|:::.......: .:|..
Human   705 -----------------------VLGLLLRLRQICCHTYL----LTNAVSSNGPSAFSL-GNDTP 741

  Fly   680 GQLKMDVLAELDKFDETDSEDDCCDEEDS----------------------TRRDGNFKLEVIKD 722
            .:|:..::.::.....:.|:::|....||                      .....:.|..:.::
Human   742 EELRKKLIRKMKLILSSGSDEECAICLDSLTVPVITHCAHVFCKPCICQVIQNEQPHAKCPLCRN 806

  Fly   723 EIKEENV----PWDSGDDLPTASSFEDQLDS-----ARALKLLNPQNPIFQFIRPSAKLKMVIDK 778
            :|.|:|:    |.:...|....|..|....|     ..||..|..:||
Human   807 DIHEDNLLECPPEELARDSEKKSDMEWTSSSKINALMHALTDLRKKNP----------------- 854

  Fly   779 LEELLTGTNDKIIVTSQWVSYLAIVRKRLQDLSWETLDFNGQLTAKEREIVLRDFNANNE---KR 840
                    |.|.:|.||:.::|:::...|:...:.....:|.:..|:|...::.|. |.|   ..
Human   855 --------NIKSLVVSQFTTFLSLIEIPLKASGFVFTRLDGSMAQKKRVESIQCFQ-NTEAGSPT 910

  Fly   841 VLLLSLTAGGVGLNLNVANHMLIVDLHWNPQLERQAQDRIYRYGQTKPTFIYRYMCQDTVEQRIK 905
            ::||||.||||||||:.|:.:.::|..|||..|.|..||.:|.||.:...|.:::.:|:||:.:.
Human   911 IMLLSLKAGGVGLNLSAASRVFLMDPAWNPAAEDQCFDRCHRLGQKQEVIITKFIVKDSVEENML 975

  Fly   906 SLQDCKLEIA 915
            .:|:.|.|:|
Human   976 KIQNKKRELA 985

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10445	NP_001246974.1	HepA	<90..945	CDD:223627	236/961 (25%)
CG10445	NP_001246974.1	DEAD-like_helicase_N	209..534	CDD:421690	114/413 (28%)
HLTF	XP_011511393.1	HIRAN	60..155	CDD:285949	19/89 (21%)
		DEXDc	238..>320	CDD:214692	28/81 (35%)
		DEXDc	288..>320	CDD:238005	18/31 (58%)
		SNF2_N	472..722	CDD:278600	89/306 (29%)
		DEXDc	<478..588	CDD:238005	39/112 (35%)
		RING	763..808	CDD:238093	4/44 (9%)
		Helicase_C	836..954	CDD:278689	41/143 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3486
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D132523at2759
OrthoFinder	1	1.000	-	-		FOG0000507
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101296
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.770