Protein Alignment CG10445 and Chd8

DIOPT Version :10

• Sequence 1: NP_649751.2
• Gene: CG10445 / 40938
• FlyBaseID: FBgn0037531
• Length: 945
• Species: Drosophila melanogaster
• Sequence 2: XP_006251970.1
• Gene: Chd8 / 65027
• RGDID: 620696
• Length: 2589
• Species: Rattus norvegicus
• Alignment Length: 979
• Identity: 198/979 - (20%)
• Similarity: 334/979 - (34%)
• Gaps: 388/979 - (39%)

  Fly    26 PVPDSSGE--------INNWMEPEP--VDSL--------EL-SGEYADNESAIFVSASEYN---- 67
            |||:..||        :.|..|.:.  ||.:        || ||:|.:.|. .||....|:
  Rat   617 PVPEPDGETLPSMQFFVENPSEEDAAIVDKVLSMRVVKKELPSGQYTEAEE-FFVKYKNYSYLHC 680

  Fly    68 --------EKKAQIDQLVQKILTMEQQQRQL----EE----NASETKELCDLKLHLEKLNARLEA 116
                    ||..:|.|.:::..|...|.|..    ||    :..|...:.|....::|.|.  |.
  Rat   681 EWATISQLEKDKRIHQKLKRFKTKMAQMRHFFHEDEEPFNPDYVEVDRILDESHSVDKDNG--EP 743

  Fly   117 LGEFL----------DTLRLREDQQEIKIED-------NSEL--VDHTEQPKWSNLYSGLNRYRQ 162
            :..:|          .|..|:||..|.||.:       :.||  |:..:...|..|
  Rat   744 VIYYLVKWCSLPYEDSTWELKEDVDEGKIREFKRIQSRHPELKRVNRPQANAWKKL--------- 799

  Fly   163 KANHTAAQFYQHKSNIIDSLKTLYEPIQPRPAIDDLEKQPALLLVRLLKHQQSCLKWMQFR--ER 225
            :.:|.    |::::                               :|.::|...:.|:.|.  .|
  Rat   800 ELSHE----YKNRN-------------------------------QLREYQLEGVNWLLFNWYNR 829

  Fly   226 QKISGGILADDMGLGKTLSMIALILASEETKNRKREEKKKALTLKWTQEFNRVYCKEIRKISMFD 290
            |..   ||||:||||||:..||                               :.:|:..:.:
  Rat   830 QNC---ILADEMGLGKTIQSIA-------------------------------FLQEVYNVGI-- 858

  Fly   291 DEEESGKEEEQYEPPEKRTCHVKTKKINQFRILDDDDNDAGDKAVVEDEQKDLLAKTPEPEVFSS 355
                                                                             
  Rat   859 ----------------------------------------------------------------- 858

  Fly   356 DEEEEHLSNGRYPSANTLVVCPMSVMCQWAHEVASKVAQNAIRVLTFHGPNRHEIGIEAFRSY-- 418
                    :|.:     ||:.|:|.:..|..|..:....|.|   .:||.......|:.:..|
  Rat   859 --------HGPF-----LVIAPLSTITNWEREFNTWTEMNTI---VYHGSLASRQMIQQYEMYCK 907

  Fly   419 -------------DLVITSYNLVVNELKRYGNTSPLFAVYWNRVILDEAHIIRNSKTNCCNSVCQ 470
                         |.:||::.:::::...      |..:.|..||:||||.::|......:|:..
  Rat   908 DSRGRLIPGAYKFDALITTFEMILSDCPE------LREIEWRCVIIDEAHRLKNRNCKLLDSLKH 966

  Fly   471 LRAHCHWALTGTPVQNRGVDVFALLRFVNVPNFQDLQQWKKNLNESMLGH--RRLNFIIKPLMLR 533
            :.......|||||:||...::|:||.|:....|....::.|:..:.....  ::|..|:||:|||
  Rat   967 MDLEHKVLLTGTPLQNTVEELFSLLHFLEPSQFPSESEFLKDFGDLKTEEQVQKLQAILKPMMLR 1031

  Fly   534 RTKQKLQASGDMPALPSLKIELICVQLSKTEMAVYQILSAISKKIFTQFLLQREKGNSDLNYYSL 598
            |.|:.::.:     |...:..:|.|:|:..:...|:   ||.:|.|: ||   .||
  Rat  1032 RLKEDVEKN-----LAPKQETIIEVELTNIQKKYYR---AILEKNFS-FL---SKG--------- 1075

  Fly   599 ERTPQFIAGHMSDERYNEIYERFLKSLGYNPGEKILGIYILVLLLRLRQFCCHPGLMIGMLRGAL 663
                   |||.:...                        :|..::.||:.|.||.|:.|
  Rat  1076 -------AGHTNMPN------------------------LLNTMMELRKCCNHPYLING------ 1103

  Fly   664 TAEDVQNVKVDASDVEGQLKMDVLAELDKFDETDSEDDCCDEEDSTRRDGNFKLEVIKDEIKEEN 728
             ||:                 .:|.|..:......:|              |.|:.:
  Rat  1104 -AEE-----------------KILMEFREACHIIPQD--------------FHLQAM-------- 1128

  Fly   729 VPWDSGDDLPTASSFEDQLDSARALKLLNPQNPIFQFIRPSAKLKMVIDKLEELLTGTNDKIIVT 793
                                                 :|.:.|| ::||||...|.....|:::.
  Rat  1129 -------------------------------------VRSAGKL-VLIDKLLPKLKAGGHKVLIF 1155

  Fly   794 SQWVSYLAIVRKRL--QDLSWETLDFNGQLTAKEREIVLRDFN-ANNEKRVLLLSLTAGGVGLNL 855
            ||.|..|.|:...|  :...:|.:|  |::....|:..:..|: .::::.|.||...|||:|:||
  Rat  1156 SQMVRCLDILEDYLIQRRYLYERID--GRVRGNLRQAAIDRFSKPDSDRFVFLLCTRAGGLGINL 1218

  Fly   856 NVANHMLIVDLHWNPQLERQAQDRIYRYGQTKPTFIYRYMCQDTVEQRIKSLQDCKLEIAKVVLP 920
            ..|:..:|.|..||||.:.|||.|.:|.||:|...:||.:.:::.|:.:......||.:.|.||.
  Rat  1219 TAADTCIIFDSDWNPQNDLQAQARCHRIGQSKAVKVYRLITRNSYEREMFDKASLKLGLDKAVLQ 1283

  Fly   921 EEGG 924
            ...|
  Rat  1284 SMSG 1287

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10445	NP_649751.2	HepA	<113..919	CDD:440319	164/846 (19%)
		DEAD-like_helicase_N	209..534	CDD:475120	64/343 (19%)
Chd8	XP_006251970.1	PHA03247	<68..279	CDD:223021
		SP1-4_N	143..>442	CDD:425404
		PTZ00121	<447..622	CDD:173412	3/4 (75%)
		CD1_tandem_CHD5-9_like	638..703	CDD:349315	16/65 (25%)
		CD2_tandem_CHD5-9_like	721..779	CDD:349310	13/59 (22%)
		PLN03142	810..>1409	CDD:215601	151/739 (20%)
		DEXHc_CHD8	811..1032	CDD:350818	64/343 (19%)
		BRK	2317..2360	CDD:462196
		BRK	2387..2426	CDD:470653