DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10445 and ttf2

DIOPT Version :9

Sequence 1:	NP_001246974.1	Gene:	CG10445 / 40938	FlyBaseID:	FBgn0037531	Length:	945	Species:	Drosophila melanogaster
Sequence 2:	XP_005168676.1	Gene:	ttf2 / 555382	ZFINID:	ZDB-GENE-110411-73	Length:	1145	Species:	Danio rerio

Alignment Length:	1037	Identity:	288/1037 - (27%)
Similarity:	449/1037 - (43%)	Gaps:	277/1037 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SSSPSDTTEIHKQSCSIQDQSSVPVPDSSGEINNWMEPEPVDSLELS-----GEYAD-NESAIFV 61
            |.|.||.|:....|||.....:|....::.::.. :||....:.:.|     ||::| ::..:.:
Zfish   288 SKSGSDKTQSQSPSCSTSQNGTVSEKPTALDVQK-IEPNQSKNKDQSGIACFGEWSDEDDDVLVI 351

  Fly    62 SASEYNEKKAQIDQL-VQKILTME---QQQRQLEENASETKEL-CDLKLHL-------------- 107
            |....:::.|....: |||.:|..   |...:::..:.:.:.| ..||..|
Zfish   352 SVQPPSQQSAPTPAVPVQKTITSYPGFQIASKVQGQSEDPRALHSQLKTQLKQKKATLSVVNVSA 416

  Fly   108 -----EKLNARLEALGEFLDTLRLREDQQEIKIEDNSELVDHTEQPKWSNLYS------------ 155
                 |:|..:::.|.|.|::|.|.. ..|.:.:|.:| .:|.....:||.:|
Zfish   417 LPDKGERLKRQVKDLEEALESLSLTA-VSESQDKDRAE-AEHKTAHSFSNPFSCPGGTILLPTAP 479

  Fly   156 ------------GLN---RYRQK--ANHTAAQFY----------QHKSNIIDSLKTLYEPIQPRP 193
                        |||   .|.|.  .|..:..||          ..::...:::..|::.::..|
Zfish   480 AAMLKESSSASLGLNLSQGYSQMFGVNPQSQAFYGGRMTENRLLAVRNATTEAIDHLHDSLESCP 544

  Fly   194 AIDDLEKQPALLLVRLLKHQQSCLKWMQFRERQKISGGILADDMGLGKTLSMIALILASEETKNR 258
            ..:.....|..|.|.||.||:..|.|:.:||.||..||||||||||||||:|||||| |::.|:.
Zfish   545 TENTEAHDPKGLKVELLPHQKRALTWLLWRETQKPCGGILADDMGLGKTLTMIALIL-SQKKKDE 608

  Fly   259 KREEKKKALTLKWTQEFNRVYCKEIRKISMFDDEEESGKEEEQYEPPEKRTCHVKTKKINQFRIL 323
            |.||        |..:.
Zfish   609 KLEE--------WISKH------------------------------------------------ 617

  Fly   324 DDDDNDAGDKAVVEDEQKDLLAKTPEPEVFSSDEEEEHLSNGRYPSANTLVVCPMSVMCQWAHEV 388
                   |...|.                                |..||::||.|::..|..|:
Zfish   618 -------GSSIVA--------------------------------SQGTLIICPASLVHHWKKEI 643

  Fly   389 ASKVAQNAIRVLTFHGPNRHEIGIEAFRSYDLVITSYNLVVNELKRY---------------GNT 438
            ..:|..:.:.|..:|||||.. .......:|:|||:|:||..|:...               .:.
Zfish   644 DKRVKSSRLTVYLYHGPNRQR-SASVLAEHDVVITTYSLVSKEIPVQKEDAEKPSKDSDHVASDL 707

  Fly   439 SPLFAVYWNRVILDEAHIIRNSKTNCCNSVCQLRAHCHWALTGTPVQNRGVDVFALLRFVNVPNF 503
            .||..|.|.||||||||.|:|.|.....:||:|||...||:||||:||..:|:::||:|:....|
Zfish   708 PPLLRVAWARVILDEAHSIKNPKVQTSMAVCKLRARSRWAVTGTPIQNNLLDMYSLLKFLRCSPF 772

  Fly   504 QDLQQWKKNL-NESMLGHRRLNFIIKPLMLRRTKQKLQASG-DMPALPSLKIELICVQLSKTEMA 566
            .:.:.||..: |.|..|..|||.:.:.|:|||||.:|.|:| .:.:||....|:..::||:.|.|
Zfish   773 DEYKLWKAQVDNGSKRGGERLNILTRALLLRRTKDQLDATGKPLVSLPDRTCEIHRLKLSEDEQA 837

  Fly   567 VYQILSAISKKIFTQFLLQREKGNSDLNYYSLERTPQFIAGHMSDERYNEIYERFLKSLGYNPGE 631
            ||.::.|.|:.....:|.:.|.||:.             .|..|:.     :|:..:..|.:..:
Zfish   838 VYDVVFAQSRSTLQNYLKRHEDGNTK-------------KGDTSNP-----FEKVAREFGMSQQD 884

  Fly   632 KILG---------IYILVLLLRLRQFCCHPGLMIGMLRGALTAEDVQNVKVDASDVEGQLKMDVL 687
            ....         |:||.|||||||.|||    :.:|:..|...::|...| |..:|.|     |
Zfish   885 SQSSSQQPQASSTIHILSLLLRLRQCCCH----LSLLKKTLDQSELQGDGV-ALSLEEQ-----L 939

  Fly   688 AELDKFDETDSEDDCCDEEDSTRRDGNFKLEVIKDEIKEENVPWDSGDDLPTASSFEDQLDSARA 752
            ..|...:.:|||:     :|:...:|                           |.|..:|
Zfish   940 CALSLSEPSDSEN-----KDTVSLNG---------------------------SHFSSEL----- 967

  Fly   753 LKLLNPQNPIFQFIRPSAKLKMVIDKLEELLTGTNDKIIVTSQWVSYLAIVRKRLQDLSWETLDF 817
                      ||..|.|.|:..::.:|:| :...:.|.::.|||.|.|.||...|:.:..:....
Zfish   968 ----------FQDTRESTKISSILTELKE-IRKKDQKSVIVSQWTSMLKIVAVHLEKMGLKFAVI 1021

  Fly   818 NGQLTAKEREIVLRDFNANNE-KRVLLLSLTAGGVGLNLNVANHMLIVDLHWNPQLERQAQDRIY 881
            :|.:..|.|..::.:||.|.: .:|:|:||.|||||:||...||:.::|:||||.||.||.||||
Zfish  1022 DGTVNPKRRMDLVEEFNTNPKGPQVMLVSLCAGGVGINLIGGNHLFLIDMHWNPALEDQACDRIY 1086

  Fly   882 RYGQTKPTFIYRYMCQDTVEQRIKSLQDCKLEIAKVVLPEEGGEVTKCVGGGLNLAELKKLF 943
            |.||:|...|:|::|..|||.:|.|||:.|.|:|:.||...|...||     |:||:|:.:|
Zfish  1087 RVGQSKDVTIHRFVCDGTVEDKISSLQEKKKELAQKVLSGTGSSFTK-----LSLADLRVIF 1143

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10445	NP_001246974.1	HepA	<90..945	CDD:223627	266/940 (28%)
CG10445	NP_001246974.1	DEAD-like_helicase_N	209..534	CDD:421690	104/340 (31%)
ttf2	XP_005168676.1	zf-GRF	4..42	CDD:284302
		SNF2_N	563..917	CDD:278600	141/472 (30%)
		DEXDc	581..752	CDD:238005	75/267 (28%)
		Helicase_C	974..1089	CDD:278689	46/115 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	253	1.000	Domainoid score	I2030
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D132523at2759
OrthoFinder	1	1.000	-	-		FOG0000507
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45626
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1278
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	7.020