DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG10445 and ERCC6L

DIOPT Version :9

Sequence 1:NP_001246974.1 Gene:CG10445 / 40938 FlyBaseID:FBgn0037531 Length:945 Species:Drosophila melanogaster
Sequence 2:NP_060139.2 Gene:ERCC6L / 54821 HGNCID:20794 Length:1250 Species:Homo sapiens


Alignment Length:929 Identity:189/929 - (20%)
Similarity:326/929 - (35%) Gaps:350/929 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly    62 SASEYNEKKAQIDQLVQKILTMEQQQRQLEENA--SETKELCDLKLHL---EKLNARLEALGEFL 121
            ::..:.|.:|...:.....|...::.::..:|.  .|..:|.:|...:   ||:.:|::      
Human     3 ASRRFPEAEALSPEQAAHYLRYVKEAKEATKNGDLEEAFKLFNLAKDIFPNEKVLSRIQ------ 61

  Fly   122 DTLRLREDQQEIKIEDNSELVDHTEQPKWSNLYSGLNRYRQKANHTAAQFYQHKSNIIDSLKTLY 186
               :::|..:|:..:.:.|..|...        |||..||:..|    |.::|:...|..|.:||
Human    62 ---KIQEALEELAEQGDDEFTDVCN--------SGLLLYRELHN----QLFEHQKEGIAFLYSLY 111

  Fly   187 EPIQPRPAIDDLEKQPALLLVRLLKHQQSCLKWMQFRERQKISGGILADDMGLGKTLSMIALILA 251
                                                |:.:|  |||||||||||||:.:||.:  
Human   112 ------------------------------------RDGRK--GGILADDMGLGKTVQIIAFL-- 136

  Fly   252 SEETKNRKREEKKKALTLKWTQEFNRVYCKEIRKISMFDDEEESGKEEEQYEPPEKRTCHVKTKK 316
                                              ..|||                       ...
Human   137 ----------------------------------SGMFD-----------------------ASL 144

  Fly   317 INQFRILDDDDNDAGDKAVVEDEQKDLLAKTPEPEVFSSDEEEEHLSNGRYPSANTLVVCPMSVM 381
            :|                                                    :.|::.|.:::
Human   145 VN----------------------------------------------------HVLLIMPTNLI 157

  Fly   382 CQWAHEVASKVAQNAIRVLTFHGPNRHEIGIEAFRSYDL---------VITSYNLVVNELKRYGN 437
            ..|..|......  .:||.|||||::.|      |:.:|         :||:|.:::|..::..:
Human   158 NTWVKEFIKWTP--GMRVKTFHGPSKDE------RTRNLNRIQQRNGVIITTYQMLINNWQQLSS 214

  Fly   438 TSPLFAVYWNRVILDEAHIIRNSKTNCCNSVC--QLRAHCHWALTGTPVQNRGVDVFALLRFV-- 498
            ......| |:.|||||||.|:.|.|.  :::|  .:.|.....|||||:||...::::|..|.  
Human   215 FRGQEFV-WDYVILDEAHKIKTSSTK--SAICARAIPASNRLLLTGTPIQNNLQELWSLFDFACQ 276

  Fly   499 -----NVPNFQDLQQWKKNL-----NESMLGHRRLNF--------IIKPLMLRRTKQKLQ--ASG 543
                 .:..|:  .:::..:     .::..|.:.|.|        ||||..|||||:.:|  .|.
Human   277 GSLLGTLKTFK--MEYENPITRAREKDATPGEKALGFKISENLMAIIKPYFLRRTKEDVQKKKSS 339

  Fly   544 DMPALPSLK---IELICVQLS---KTEMAVYQILSAISKKIFTQFLLQREKGNSDLNYYSLERTP 602
            :..|..:.|   ::.||...|   |.::.::..|..:.::|:.:|:             ||:...
Human   340 NPEARLNEKNPDVDAICEMPSLSRKNDLIIWIRLVPLQEEIYRKFV-------------SLDHIK 391

  Fly   603 QFIAGHMSDERYNEIYERFLKSLGYNPGEKILGIYILVLLLRLRQFCCHPGLMIGMLRGALTAED 667
            :.:.     |..:.:.|              ||:        |::.|.||.|:            
Human   392 ELLM-----ETRSPLAE--------------LGV--------LKKLCDHPRLL------------ 417

  Fly   668 VQNVKVDASDVEGQLKMDVLAELDKFDETDSEDDCC--DEEDSTRRDGNFKLEVIKDEIKEENVP 730
                                          |...||  :....:.:|||                
Human   418 ------------------------------SARACCLLNLGTFSAQDGN---------------- 436

  Fly   731 WDSGDDLPTASSFEDQLDSARALKLLNPQNPIFQFIRPSAKLKMVIDKLEELLTGTNDKIIVTSQ 795
              .|:|.|.....:...|..              .:..|.|:..::|.|:. |.....:.:|.||
Human   437 --EGEDSPDVDHIDQVTDDT--------------LMEESGKMIFLMDLLKR-LRDEGHQTLVFSQ 484

  Fly   796 WVSYLAIVRKRLQDLSWETLDFNGQLT-AKEREIVLRDFNANNEKRVLLLSLTAGGVGLNLNVAN 859
            ....|.|:.:.|::..::||..:|.:| ..|||..:..|..|.:..|.||:...|||||.|..|.
Human   485 SRQILNIIERLLKNRHFKTLRIDGTVTHLLEREKRINLFQQNKDYSVFLLTTQVGGVGLTLTAAT 549

  Fly   860 HMLIVDLHWNPQLERQAQDRIYRYGQTKPTFIYRYMCQDTVEQRIKSLQDCKLEIAKVVLPEEGG 924
            .::|.|..|||..:.||.||:||.||.:...:||.:...|||::|...|..|..:.:....|:..
Human   550 RVVIFDPSWNPATDAQAVDRVYRIGQKENVVVYRLITCGTVEEKIYRRQVFKDSLIRQTTGEKKN 614

  Fly   925 EVTKCVGGGLNLAELKKLF 943
            ....     .:..||::||
Human   615 PFRY-----FSKQELRELF 628

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG10445NP_001246974.1 HepA <90..945 CDD:223627 186/901 (21%)
DEAD-like_helicase_N 209..534 CDD:421690 71/355 (20%)
ERCC6LNP_060139.2 TPR 1 21..54 5/32 (16%)
SNF2_N 99..417 CDD:278600 101/519 (19%)
DEXDc 116..259 CDD:238005 55/266 (21%)
DEAH box 228..231 2/2 (100%)
Helicase_C 459..574 CDD:278689 41/115 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 735..768
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 926..946
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1061..1092
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1110..1199
TPR 2 1200..1233
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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