DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10445 and XNP

DIOPT Version :9

Sequence 1:	NP_001246974.1	Gene:	CG10445 / 40938	FlyBaseID:	FBgn0037531	Length:	945	Species:	Drosophila melanogaster
Sequence 2:	NP_651398.1	Gene:	XNP / 43080	FlyBaseID:	FBgn0039338	Length:	1311	Species:	Drosophila melanogaster

Alignment Length:	1144	Identity:	249/1144 - (21%)
Similarity:	413/1144 - (36%)	Gaps:	324/1144 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MESSSPSD--------TTEIHKQSCSIQ---------------------DQSSVPVPDSSGEINN 36
            :.|||.||        ..|..:..|.|:                     .|.:|.:.|||.|
  Fly    68 VSSSSDSDQAVANSSANDEEKEPVCKIRIVPLEKLLASPKTKERPSRGSQQKNVTINDSSDE--- 129

  Fly    37 WMEPEPVDSLELSGEYADNESAIFVSASEYNEKKAQIDQLVQKI-LTMEQQQRQLEENASE-TKE 99
              ||.....|.|....:.|::|..:..|:..|...:.:.|:..| |..|.||.:.|:|:|: :||
  Fly   130 --EPLKGSKLVLPARKSRNKNASIIELSDSEEVDEEEESLLVAIPLPKEAQQTKPEKNSSKASKE 192

  Fly   100 LCD--LKLHLEKLNARLEALGEFLDTLR--LREDQQEIKIEDNSE------------------LV 142
            ..:  .|...|...:...|:.....|.|  |..::........:|                  ..
  Fly   193 SIEKRQKAQKEATTSSARAIRSVNGTRRGSLSSERSSRASSSRAESPPRPKRCVVRLKRVSLPKT 257

  Fly   143 DHTEQPKWSNLYSGLNRYRQKANHTAAQFYQHKSNIIDSLKTLYEPIQPRPAID----------- 196
            ...::||      .::...::|..|:.:..|.:|.......:.||    .||.:
  Fly   258 KPAQKPK------KMSSDSEEAATTSKKSRQRRSKSESEADSDYE----APAAEEEEEEERKSSG 312

  Fly   197 ---------DLEKQPALLLVRLLKHQQSCLKWMQFRERQKISG-------------GILADDMGL 239
                     |.|..|.....|............:..|:||..|             |...||...
  Fly   313 DEEEAANSSDSEVMPQRKRRRKKSESDKGSSDFEPEEKQKKKGRKRIKKTSSGESDGDGDDDKQK 377

  Fly   240 G-----------KTLSMIALILASEETKNRKREEKKKALTLKWTQEFNRVYCK----EIRKISMF 289
            .           |.|.:.....|.||...|||.|.::.|       :||::.|    ||.:: :.
  Fly   378 NKRKHIRKIIKTKDLDLTTKEAAKEEDDRRKRIEDRQKL-------YNRIFVKSESVEINEL-VL 434

  Fly   290 DDEEESGKEEEQYEPP--EKRTCH----VKTKKINQFRILDDDDNDAGDKAVVEDEQKDLLAKTP 348
            |.:|||.|...|.:..  :|...|    ||......|..|.:.....|...::.....  |.||.
  Fly   435 DFDEESKKALLQVDKGLLKKLKPHQVAGVKFMWDACFETLKESQEKPGSGCILAHCMG--LGKTL 497

  Fly   349 EPEVFSSDEEEEH--LSNGRYPSAN-TLVVCPMSVMCQWAHEVAS--KVA-QNAIRVLTF----H 403
            :....|      |  |.|.|....: .|::.|:|.:..||.|..|  |.| :|.|.|...    .
  Fly   498 QVVTLS------HTLLVNTRRTGVDRVLIISPLSTVNNWAREFTSWMKFANRNDIEVYDISRYKD 556

  Fly   404 GPNR--------HEIGIEAFRSYDLVITSYNLVVNE----LKRYGNTSPLFAVY---WNRVILDE 453
            .|.|        :|.|: ....||:    |.::.||    |::......:.|:.   .:.|:.||
  Fly   557 KPTRIFKLNEWFNEGGV-CILGYDM----YRILANEKAKGLRKKQREQLMQALVDPGPDLVVCDE 616

  Fly   454 AHIIRNSKTNCCNSVCQLRAHCHWALTGTPVQNRGVDVFALLRFVNVPNFQDLQQWKKNLNE--- 515
            .|:::|.||:...:|.::|......|||||:||...:.:.:::||. ||.  |..:|:.:|.
  Fly   617 GHLLKNEKTSISKAVTRMRTKRRIVLTGTPLQNNLREYYCMIQFVK-PNL--LGTYKEYMNRFVN 678

  Fly   516 ---------------SMLGHRR--LNFIIKPLMLRRTKQKLQASGDMPALPSLKIELICVQLSKT 563
                           .::.||.  |:.:::..:.||....|     .|.||           .|.
  Fly   679 PITNGQYTDSTERDLRLMKHRSHILHKLLEGCIQRRDYSVL-----APYLP-----------PKH 727

  Fly   564 EMAVYQILSAISKKIFTQFL-LQREKGNSDLNYYSLERTPQFIAGHMSDERYNEIYERFLKSLGY 627
            |..||..||.:.:|::..:: ..||:...|            :.|     :...:::.|..
  Fly   728 EYVVYTTLSELQQKLYGYYMTTHREQSGGD------------VVG-----KGARLFQDFQD---- 771

  Fly   628 NPGEKILGIYILVLLLRLRQFCCHPGLMIGMLRGALTAEDVQNVKVDASDVEGQLKMDVLAELDK 692
                             ||:...||                .|::|::.:|       :...|..
  Fly   772 -----------------LRRIWTHP----------------MNLRVNSDNV-------IAKRLLS 796

  Fly   693 FDETDSEDDCCDE--EDSTRRDGNFKLEVIKDEIKEENVPWDSG--DDLPTASSFEDQLDSARAL 753
            .|::|.|...|||  ||....:.:...|..|.:.....:...||  ....|.:......||...|
  Fly   797 NDDSDMEGFICDETDEDEAASNSSDSCETFKSDASMSGLAASSGKVKKRKTRNGNAGGGDSDSDL 861

  Fly   754 KLL------------NPQNPIFQFIRP--------SAKLKMVIDKLEELLTGTNDKIIVTSQWVS 798
            ::|            :|......|:..        |.|| :::.:|.:......||::|.||.:.
  Fly   862 EMLGGLGGGSSVQKDDPSEWWKPFVEERELNNVHHSPKL-LILLRLLQQCEAIGDKLLVFSQSLQ 925

  Fly   799 YLAIVRK--RLQDLSWETLDFNGQL--------------------TAKEREIVLRDFN--ANNEK 839
            .|.::..  .|.|.:.:..:|.|.:                    :.::||.:.:.||  .|...
  Fly   926 SLDVIEHFLSLVDSNTKNYEFEGDVGDFKGCWTSGKDYFRLDGSCSVEQREAMCKQFNNITNLRA 990

  Fly   840 RVLLLSLTAGGVGLNLNVANHMLIVDLHWNPQLERQAQDRIYRYGQTKPTFIYRYMCQDTVEQRI 904
            |:.|:|..|||:|:||..||.::|.|:.|||..:.|:..|:||:||.||.:|||.:...|:||::
  Fly   991 RLFLISTRAGGLGINLVAANRVVIFDVSWNPSHDTQSIFRVYRFGQIKPCYIYRLIAMGTMEQKV 1055

  Fly   905 KSLQDCKLEIAKVVLPEEGGEVTKCVGGGLNLAELKKLF 943
            ...|..|...||.|:.|:.      :....|..:|.:|:
  Fly  1056 YERQVAKQATAKRVIDEQQ------ISRHYNQTDLMELY 1088

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10445	NP_001246974.1	HepA	<90..945	CDD:223627	221/1025 (22%)
CG10445	NP_001246974.1	DEAD-like_helicase_N	209..534	CDD:421690	92/403 (23%)
XNP	NP_651398.1	DTHCT	258..335	CDD:285332	14/86 (16%)
		SNF2_N	458..779	CDD:278600	83/390 (21%)
		DEXDc	483..646	CDD:238005	43/175 (25%)
		Helicase_C	913..1035	CDD:278689	35/121 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467136
Domainoid	1	1.000	47	1.000	Domainoid score	I705
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.930