DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10445 and Hel89B

DIOPT Version :9

Sequence 1:	NP_001246974.1	Gene:	CG10445 / 40938	FlyBaseID:	FBgn0037531	Length:	945	Species:	Drosophila melanogaster
Sequence 2:	NP_001287351.1	Gene:	Hel89B / 41943	FlyBaseID:	FBgn0022787	Length:	1923	Species:	Drosophila melanogaster

Alignment Length:	792	Identity:	174/792 - (21%)
Similarity:	299/792 - (37%)	Gaps:	285/792 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   173 QHKSNIIDSLKTLYEPIQPRPAIDDL--------EKQPALLLVRLLKHQQSCLKWMQFRERQKIS 229
            |.||:.:.:.||     :.|..:|.|        .|.|..:.|.|..:||:.:.|:.|..:..:.
  Fly  1311 QLKSDPLQARKT-----RDREFLDYLFNPKSIPNYKVPVPISVELRCYQQAGINWLWFLNKYNLH 1370

  Fly   230 GGILADDMGLGKTLSMIALILASEETKNRKREEKKKALTLKWTQEFNRVYCKEIRKISMFDDEEE 294
             |||.|||||||||..|. |||.:
  Fly  1371 -GILCDDMGLGKTLQTIC-ILAGD----------------------------------------- 1392

  Fly   295 SGKEEEQYEPPEKRTCHVKTKKINQFRILDDDDNDAGDKAVVEDEQKDLLAKTPEPEVFSSDEEE 359
                            |:..:..|                         ||..|
  Fly  1393 ----------------HMHRQTAN-------------------------LANLP----------- 1405

  Fly   360 EHLSNGRYPSANTLVVCPMSVMCQWAHEVASKVAQNAI-RVLTFHGPNRHEIGIEAFRS-----Y 418
                        :||:||.::...|.:||...:.|.:: |.|.::|   ..:|.|..||     .
  Fly  1406 ------------SLVICPPTLTGHWVYEVEKFLDQGSVLRPLHYYG---FPVGREKLRSDIGTKC 1455

  Fly   419 DLVITSYNLVVNELKRYGNTSPLFAVYWNRVILDEAHIIRNSKTNCCNSVCQLRAHCHWALTGTP 483
            :||:.||:.|..::..:.      .:::|..:|||.|||:|.||....::.:|:|:....|:|||
  Fly  1456 NLVVASYDTVRKDIDFFS------GIHFNYCVLDEGHIIKNGKTKSSKAIKRLKANHRLILSGTP 1514

  Fly   484 VQNRGVDVFALLRFVNVPNF------------------QDLQQWKKNLNESMLGHRRLNFIIKPL 530
            :||..:::::|..|: :|.|                  :|.:...|.....:|....|:..:.|.
  Fly  1515 IQNNVLELWSLFDFL-MPGFLGTEKQFVQRFSRPILSSRDAKSSAKEQEAGVLAMEALHRQVLPF 1578

  Fly   531 MLRRTKQKLQASGDMPALPSLKIELICVQLSKTEMAVYQILSAISKKIFTQFLLQREKGNSDLNY 595
            :|||.|:.:..  |:|  |.:..:|:| :||..::.:|:
  Fly  1579 LLRRVKEDVLK--DLP--PKITQDLLC-ELSPLQLRLYE-------------------------- 1612

  Fly   596 YSLERTPQFIAGHMSDERYNEIYERFLKSLGYNPGEKIL------GIYILVLLLRLRQFCCHPGL 654
                   .|...|:.|         .|..||.:....::      ..:|...|..|:..|.||.|
  Fly  1613 -------DFSNKHLKD---------CLDKLGDSSSASMVTENLSAKTHIFQALRYLQNVCNHPKL 1661

  Fly   655 MIGMLRGALTAEDVQNVKVDASDVEGQLKMDVLAELDKFDETDSEDDCCDEEDSTRRDGNFKLEV 719
            ::..      :|::       :.|..||.:          ...|.||.         :.:.||..
  Fly  1662 VLRQ------SEEL-------TKVTSQLAL----------SNSSLDDI---------EHSAKLPA 1694

  Fly   720 IKDEIKEENVPWDSGDDLPTASSFEDQLDSARALKLLNPQNPIFQFIRPSAKLKMVIDKLEELLT 784
            :|..:      .|.|..:.|.|     :...|||        ||      .:||.::|.:|:
  Fly  1695 LKQLL------LDCGIGVQTES-----VSQHRAL--------IF------CQLKAMLDIVEQ--- 1731

  Fly   785 GTNDKIIVTSQWVSYLAIVRKRLQDLSWETLDFNGQLTAKEREIVLRDFNANNEKRVLLLSLTAG 849
                            .::|:.|..:::..||  |.:.|.:|:.::.:||::....||||:...|
  Fly  1732 ----------------DLLRRHLPSVTYLRLD--GSVPASQRQDIVNNFNSDPSIDVLLLTTMVG 1778

  Fly   850 GVGLNLNVANHMLIVDLHWNPQLERQAQDRIYRYGQTKPTFIYRYMCQDTVEQRIKSLQDCKLEI 914
            |:||||..|:.::.|:..|||..:.||.||.:|.||.|...:||.:.::::|::|..||..|:..
  Fly  1779 GLGLNLTGADTVIFVEHDWNPMKDLQAMDRAHRIGQKKVVNVYRLITRNSLEEKIMGLQKFKILT 1843

  Fly   915 AKVVLPEEGGEV 926
            |..|:..|...:
  Fly  1844 ANTVVSAENASL 1855

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10445	NP_001246974.1	HepA	<90..945	CDD:223627	174/792 (22%)
CG10445	NP_001246974.1	DEAD-like_helicase_N	209..534	CDD:421690	74/348 (21%)
Hel89B	NP_001287351.1	HEAT repeat	5..30	CDD:293787
		HEAT repeat	42..70	CDD:293787
		HEAT repeat	395..420	CDD:293787
		HEAT repeat	433..465	CDD:293787
		HEAT repeat	475..504	CDD:293787
		HEAT repeat	516..540	CDD:293787
		HEAT repeat	560..589	CDD:293787
		DUF3535	654..1138	CDD:288874
		HEAT repeat	1234..1261	CDD:293787
		HEAT repeat	1269..1298	CDD:293787
		SNF2_N	1353..1662	CDD:278600	96/472 (20%)
		DEXDc	1370..1514	CDD:238005	55/259 (21%)
		Helicase_C	1689..1813	CDD:278689	45/169 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467135
Domainoid	1	1.000	47	1.000	Domainoid score	I705
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.840