DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10445 and brm

DIOPT Version :9

Sequence 1:	NP_001246974.1	Gene:	CG10445 / 40938	FlyBaseID:	FBgn0037531	Length:	945	Species:	Drosophila melanogaster
Sequence 2:	NP_001261906.1	Gene:	brm / 39744	FlyBaseID:	FBgn0000212	Length:	1658	Species:	Drosophila melanogaster

Alignment Length:	965	Identity:	199/965 - (20%)
Similarity:	339/965 - (35%)	Gaps:	378/965 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 SEYNEKKAQIDQLVQKILTMEQQQRQLEENASETKELCDLKLHLEKLNARLEALGEFLDTL---- 124
            :|..:||.|  :.::|    |:.:|.:.|:....::|.|.|.. ::|...|....|::..|
  Fly   552 AEREQKKEQ--ERIEK----ERMRRLMAEDEEGYRKLIDQKKD-KRLAFLLSQTDEYISNLTQMV 609

  Fly   125 -RLREDQQEIKIEDNSELVDHTEQPKWSNLYSGLNRYRQKAN---HTAAQFYQHKSNIIDS--LK 183
             :.::||.:.|.|:...|:...::...|..|.|::.....|:   |...|....|....|:  ||
  Fly   610 KQHKDDQMKKKEEEGKRLIQFKKELLMSGEYIGIDEGSIVADMRVHVVEQCTGKKLTGDDAPMLK 674

  Fly   184 TLYEPIQPRPA---IDD--------------LEKQP----------------------------- 202
            .|:..:...|.   |||              :|:||
  Fly   675 HLHRWLNMHPGWDWIDDEEDSCGSNDDHKPKVEEQPTATEDATDKAQATGNDEDAKDLITKAKVE 739

  Fly   203 -------------------------ALLLVR--LLKHQQSCLKWMQFRERQKISGGILADDMGLG 240
                                     |.::|.  |.::|...|:|:.......:: |||||:||||
  Fly   740 DDEYRTEEQTYYSIAHTIHEKVVEQASIMVNGTLKEYQIKGLEWLVSLYNNNLN-GILADEMGLG 803

  Fly   241 KTLSMIALILASEETKNRKREEKKKALTLKWTQEFNRVYCKEIRKISMFDDEEESGKEEEQYEPP 305
            ||:..|:|:                            .|..:.:|:.
  Fly   804 KTIQTISLV----------------------------TYLMDRKKVM------------------ 822

  Fly   306 EKRTCHVKTKKINQFRILDDDDNDAGDKAVVEDEQKDLLAKTPEPEVFSSDEEEEHLSNGRYPSA 370
                                                                       |.|
  Fly   823 -----------------------------------------------------------GPY--- 825

  Fly   371 NTLVVCPMSVMCQWAHEVASKVAQNAIRVLTFHG-PNRHEIGIEAFRS--YDLVITSYNLVVNEL 432
              |::.|:|.:..|..|. .|.|. |:.|:::.| |....:.....|:  :::::|:|..|:.:
  Fly   826 --LIIVPLSTLPNWVLEF-EKWAP-AVGVVSYKGSPQGRRLLQNQMRATKFNVLLTTYEYVIKD- 885

  Fly   433 KRYGNTSPLFAVYWNRVILDEAHIIRNSKTNCCNSVCQLRAH----CHWALTGTPVQNRGVDVFA 493
                 .:.|..:.|..:|:||.|.::|   :.|.....|..|    ....|||||:||:..:::|
  Fly   886 -----KAVLAKIQWKYMIIDEGHRMKN---HHCKLTQVLNTHYIAPYRLLLTGTPLQNKLPELWA 942

  Fly   494 LLRFVNVPNFQD---LQQW----------KKNLN--ESMLGHRRLNFIIKPLMLRRTKQKLQASG 543
            ||.|:....|:.   .:||          |..||  |::|..|||:.:::|.:|||.|::::..
  Fly   943 LLNFLLPSIFKSCSTFEQWFNAPFATTGEKVELNEEETILIIRRLHKVLRPFLLRRLKKEVEHQ- 1006

  Fly   544 DMPALPSLKIE-LICVQLSKTEMAVYQILSAISKKIFTQFLLQ--REKGNSDLNYYSLERTPQFI 605
                ||. |:| :|...:|..:..:|:.:.  ||.:    ||.  .|||...
  Fly  1007 ----LPD-KVEYIIKCDMSALQRVLYKHMQ--SKGV----LLTDGSEKGKHG------------- 1047

  Fly   606 AGHMSDERYNEIYERFLKSLGYNPGEKILGIYILVLLLRLRQFCCHPGLMIGMLRGALTAEDVQN 670
                                  ..|.|.|    :..:::||:.|.||.:.             |:
  Fly  1048 ----------------------KGGAKAL----MNTIVQLRKLCNHPFMF-------------QH 1073

  Fly   671 VKVDASDVEGQLKMDVLAELDKFDETDSEDDCCDEEDSTRRDGNFKLEVIKDEIKEENVPWDSGD 735
            :                           |:..||.   |...|     |:            ||.
  Fly  1074 I---------------------------EEKYCDH---TGGHG-----VV------------SGP 1091

  Fly   736 DLPTASSFEDQLDSARALKLLNPQNPIFQFIRPSAKLKMVIDKLEELLTGTNDKIIVTSQWVSYL 800
            ||                            .|.|.|.:: :|::...|..||.::::..|....:
  Fly  1092 DL----------------------------YRVSGKFEL-LDRILPKLKATNHRVLLFCQMTQCM 1127

  Fly   801 AIVRKRLQDLSWETLDFNGQLTAKEREIVLRDFNA-NNEKRVLLLSLTAGGVGLNLNVANHMLIV 864
            .|:...|....:..|..:|...|::|..:||.||| .::..|.|||..|||:||||..|:.::|.
  Fly  1128 TIIEDYLGWRQFGYLRLDGTTKAEDRGELLRKFNAKGSDVFVFLLSTRAGGLGLNLQTADTVVIF 1192

  Fly   865 DLHWNPQLERQAQDRIYRYGQTKPTFIYRYMCQDTVEQRIKSLQDCKLEIAKVVL 919
            |..|||..:.|||||.:|.||.....:.|.|..::||:||.:....||.:.:.|:
  Fly  1193 DSDWNPHQDLQAQDRAHRIGQRNEVRVLRLMTVNSVEERILAAARYKLNMDEKVI 1247

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10445	NP_001246974.1	HepA	<90..945	CDD:223627	192/939 (20%)
CG10445	NP_001246974.1	DEAD-like_helicase_N	209..534	CDD:421690	70/346 (20%)
brm	NP_001261906.1	QLQ	172..202	CDD:214931
		Drf_FH1	251..390	CDD:283903
		HSA	501..573	CDD:214727	7/26 (27%)
		BRK	649..693	CDD:197800	12/43 (28%)
		PHA02934	687..>824	CDD:165245	27/242 (11%)
		SNF2_N	776..1071	CDD:278600	94/467 (20%)
		DEXDc	793..932	CDD:238005	45/260 (17%)
		Helicase_C	1097..1212	CDD:278689	41/115 (36%)
		SnAC	1304..1375	CDD:291293
		Bromo_SNF2L2	1425..1530	CDD:99947
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467129
Domainoid	1	1.000	47	1.000	Domainoid score	I705
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.930