DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10445 and hltf

DIOPT Version :9

Sequence 1:	NP_001246974.1	Gene:	CG10445 / 40938	FlyBaseID:	FBgn0037531	Length:	945	Species:	Drosophila melanogaster
Sequence 2:	XP_004914419.1	Gene:	hltf / 394525	XenbaseID:	XB-GENE-494079	Length:	985	Species:	Xenopus tropicalis

Alignment Length:	1044	Identity:	263/1044 - (25%)
Similarity:	430/1044 - (41%)	Gaps:	246/1044 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 TEIHKQSCSIQDQSSVPVPDSSGEINNWMEPEPVDSLELSGEYADNESAIF-------VSASEYN 67
            |..|.|..|......:...|.|||          |:..|:....|.:|||.       |....|.
Frog    22 TANHSQFSSSNIFFHLEEDDLSGE----------DTSSLADSQEDFDSAILFGMLRGNVVGLRYY 76

  Fly    68 EKKAQIDQLVQKILTMEQQQRQLEENASETKELCDLKL-HLEKLNARLEALGEFLDTLRLREDQQ 131
            ......:::|   ....:...|.:.||.:...:...:: |::|..|  .||...|       ||:
Frog    77 SGVVNNNEMV---ALQREPNNQYDRNAVKVNNVNGEQVGHIKKELA--AALAHIL-------DQK 129

  Fly   132 EIKIE-----------------------DNSELV-DHTEQ------PKWSNLYSGLNRYRQKANH 166
            ..|||                       :|.:.| ||..:      |..::|..|....:.|:..
Frog   130 MAKIEGVVPYGAQNAFTMPVNLSFWGRAENKQAVLDHMMKYGFRLGPIPNSLQLGHGSAKSKSER 194

  Fly   167 TAAQFYQHKSNII-------DSLKT----LYEPIQPRPAIDDLEKQPALLL-VRLLKHQQSCLKW 219
            ....:   ::.|:       :.|||    |:|.::......:||  ||..: .:||.||:..|.|
Frog   195 AGPSY---RAPILPAVQMTTEQLKTEFDKLFEDLKEDDKTQELE--PAETIGTQLLSHQKQALSW 254

  Fly   220 M-------------------------QFRERQK---ISGGILADDMGLGKTLSMIALILAS---- 252
            |                         .|.|:||   :.|||||||||||||||:|||||.:
Frog   255 MVSRENTEELPPFWEERNHLYYNTLTNFAEKQKPENVRGGILADDMGLGKTLSVIALILTNFYDG 319

  Fly   253 --EETKNRKREEKKKALTLKWTQEFNRVYCKEIRKISMFDD---EEESGKEEEQYEPPEKRTCHV 312
              ..||..|::|..::..||  ...::...|..:|..:..|   |.|:..:|.....|:::...
Frog   320 RPFPTKKIKKQELAESDVLK--SNMSQKQFKAAKKTELSTDSRKESETLSQEASSSRPKRQKAR- 381

  Fly   313 KTK------------------KINQFRILDDDDNDA----GDKAVVEDEQKDLLAKTPEPEVFSS 355
            |||                  |......|.|||..|    |....|. ::|:....|....:..:
Frog   382 KTKYTYSSASEEDEAWLPRKVKAPAECTLHDDDLFANALFGLPTAVR-KKKNKKGVTVSQSISKA 445

  Fly   356 DEEEEHLSNGRYPSANTLVVCPMSVMCQWAHEVASKVAQNA-IRVLTFHGPNRHEIGIEAFRSYD 419
            ..|.:.        ..||::||:||:..|..:....:.... :.:..::||.|.: ..:.....|
Frog   446 GPEGQR--------RTTLIICPLSVLSNWIDQFEQHIKPEVHLNIYIYYGPERTK-DPKVLSDQD 501

  Fly   420 LVITSYNLVVNELKRYG--NTSPLFAVYWNRVILDEAHIIRNSKTNCCNSVCQLRAHCHWALTGT 482
            :|:|:|:::.::   ||  :.|||..|.|.||:|||.|.|||.......:|..|.|...|.||||
Frog   502 VVVTTYSVLSSD---YGSRSESPLHKVKWLRVVLDEGHTIRNPNAQQTQAVLSLEAQRRWILTGT 563

  Fly   483 PVQNRGVDVFALLRFVNVPNFQDLQQWKKNLNESML-----GHRRLNFIIKPLMLRRTKQKLQAS 542
            |:||...|:::|:.|:.:..|.|.:.|.:.:...:.     |..||..:||.:.|||||......
Frog   564 PIQNSLKDLWSLICFLKLKPFTDREWWHRTIQRPVTTGEDGGLCRLQALIKNITLRRTKTSKIRG 628

  Fly   543 GDMPALPSLKIELICVQLSKTEMAVYQILSAISKKIFTQFLLQREKGNSDLNYYSLERTPQFIAG 607
            ..:..||..|:.:..|:||:.|..:|:.|              :.:|.:.::.|..|.|   |..
Frog   629 RPVLDLPERKVFIQHVELSEEERQIYESL--------------KNEGKAVISRYVSEGT---ILS 676

  Fly   608 HMSDERYNEIYERFLKSLGYNPGEKILGIYILVLLLRLRQFCCHPGLMIGMLRGALTAEDVQNVK 672
            |.:|                          :|.:|:||||.||||.|:...|....|..|
Frog   677 HYAD--------------------------VLAVLVRLRQLCCHPFLVSSALSSITTTAD----- 710

  Fly   673 VDASDVEGQLKMDVLAELDKFDETDSEDDCCDEEDSTRRDGNFKL--------------EVIKDE 723
                ...|.::..::.::.....:.|:::|....||.    |..:              :||:.|
Frog   711 ----STPGDVREKLVQKIKLVLSSGSDEECAICLDSL----NMPVITYCAHVFCKPCICQVIQHE 767

  Fly   724 IKEENVPWDSG----DDLPTASSFEDQLDSARALKLLNPQNPIFQFIRPSAKLKMVIDKL-EELL 783
            .:|...|...|    |.|....  ::.|||:...||  .||.:.     |.|:..::..| ::..
Frog   768 KQEAKCPLCRGSLRLDQLVECP--QEDLDSSINKKL--EQNWMC-----STKINALMHALVDQRR 823

  Fly   784 TGTNDKIIVTSQWVSYLAIVRKRLQDLSWETLDFNGQLTAKEREIVLRDFNANNEK--RVLLLSL 846
            .....|.||.||:.|:|:::...|::..:.....:|.:|.|:|...::.|...:.:  .::||||
Frog   824 KDATVKSIVVSQFTSFLSVIEVALRESGFMFTRLDGSMTQKKRTEAIQSFQRPDAQSPTIMLLSL 888

  Fly   847 TAGGVGLNLNVANHMLIVDLHWNPQLERQAQDRIYRYGQTKPTFIYRYMCQDTVEQRIKSLQDCK 911
            .||||||||..|:.:.::|..|||..|.|..||.:|.||||...:.:::.:::||:.:..:|..|
Frog   889 KAGGVGLNLTAASRVFLMDPAWNPAAEEQCFDRCHRLGQTKKVIVTKFVVRNSVEENMLKIQSKK 953

  Fly   912 LEIA 915
            .|:|
Frog   954 RELA 957

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10445	NP_001246974.1	HepA	<90..945	CDD:223627	245/957 (26%)
CG10445	NP_001246974.1	DEAD-like_helicase_N	209..534	CDD:421690	111/391 (28%)
hltf	XP_004914419.1	HIRAN	63..156	CDD:370129	17/104 (16%)
		DEAD-like_helicase_N	244..620	CDD:391939	111/391 (28%)
		HepA	<453..962	CDD:223627	156/574 (27%)
		RAD18	736..>799	CDD:227719	15/68 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D132523at2759
OrthoFinder	1	1.000	-	-		FOG0000507
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010