Protein Alignment CG10445 and ERCC6L2

DIOPT Version :10

• Sequence 1: NP_649751.2
• Gene: CG10445 / 40938
• FlyBaseID: FBgn0037531
• Length: 945
• Species: Drosophila melanogaster
• Sequence 2: NP_064592.3
• Gene: ERCC6L2 / 375748
• HGNCID: 26922
• Length: 1550
• Species: Homo sapiens
• Alignment Length: 961
• Identity: 187/961 - (19%)
• Similarity: 333/961 - (34%)
• Gaps: 335/961 - (34%)

  Fly     1 MESSSPSDTTEIH-KQSCSIQDQSSVPVPDSSGEINNWMEPEPVDSLELSGEYADNESAIFVSAS 64
            |:.|:|....|.. |......::...|.||:.......::...||.        :.:|...|..:
Human     1 MDPSAPQPRAETSGKDIWHPGERCLAPSPDNGKLCEASIKSITVDE--------NGKSFAVVLYA 57

  Fly    65 EYNEKKAQIDQLVQKILTMEQQQRQL---EENASETKELCDLKLHLEKLNARLEALGEFLDTLRL 126
            ::.|:|..:.|| |::..::...|.|   :|:             |||         .:....:.
Human    58 DFQERKIPLKQL-QEVKFVKDCPRNLIFDDED-------------LEK---------PYFPNRKF 99

  Fly   127 REDQQEIKIEDNSELVDHTEQPKWSNLYSGLNRYRQKANHTAAQF-YQHKSNIIDSLKTLYEPIQ 190
            .......|:.||.:.:.:|           :|||.:.......:| |.|
Human   100 PSSSVAFKLSDNGDSIPYT-----------INRYLRDYQREGTRFLYGH---------------- 137

  Fly   191 PRPAIDDLEKQPALLLVRLLKHQQSCLKWMQFRERQKISGG--ILADDMGLGKTLSMIALILASE 253
                                                .|.||  ||.||||||||:.:|:.:.|
Human   138 ------------------------------------YIHGGGCILGDDMGLGKTVQVISFLAA-- 164

  Fly   254 ETKNRKREEKKKALTLKWTQEFNRVYCKEIRKISMFDDEEESGKEEEQYEPPEKRTCHVKTKKIN 318
                                                                      |..||
Human   165 ----------------------------------------------------------VLHKK-- 169

  Fly   319 QFRILDDDDNDAGDKAVVEDEQKDLLAKTPEPEVFSSDEEEEHLSNGRYPSANTLVVCPMSVMCQ 383
                        |.:..:|:...:.|.::.:.|..||..::..           |:|.|:||:..
Human   170 ------------GTREDIENNMPEFLLRSMKKEPLSSTAKKMF-----------LIVAPLSVLYN 211

  Fly   384 WAHEVASKVAQNAIRVLTFHGPNRHE---IGIEAFRSYDLVITSY---NLVVNELKRYGNTSPLF 442
            |..|:.:   ....||...|| ||.:   |.::. |..::.:|:|   .|.::||.
Human   212 WKDELDT---WGYFRVTVLHG-NRKDNELIRVKQ-RKCEIALTTYETLRLCLDELN--------- 262

  Fly   443 AVYWNRVILDEAHIIRNSKTNCCNSVCQLRAHCHWALTGTPVQNRGVDVFALLRFVNVP------ 501
            ::.|:.||:||||.|:|.|......:..|:.:....||||.:||...:::.::.:. ||
Human   263 SLEWSAVIVDEAHRIKNPKARVTEVMKALKCNVRIGLTGTILQNNMKELWCVMDWA-VPGLLGSG 326

  Fly   502 -----NFQDL----QQWKKNLNESMLGHRRLNFIIKPL---MLRRTKQKLQASGDMPALPSLKIE 554
                 .|.|.    |:......|...|.:.:..:.|.:   .|||||..::     ..||..:..
Human   327 TYFKKQFSDPVEHGQRHTATKRELATGRKAMQRLAKKMSGWFLRRTKTLIK-----DQLPKKEDR 386

  Fly   555 LICVQLSKTEMAVYQILSAISKKIFTQFLLQREKGNSDLNYYSLERTPQFIAGHMSDERYNEIYE 619
            ::...|:..:.||||  :.:..:..|..|...|....        |:.|        :|.|..|:
Human   387 MVYCSLTDFQKAVYQ--TVLETEDVTLILQSSEPCTC--------RSGQ--------KRRNCCYK 433

  Fly   620 RFLKSLGYNPGEKILGIYILVLLLRLRQFCCHPGLMIGMLRGALTAEDVQNVKVDASDVEGQLKM 684
            .      .:.||.:..:|:..|.: |::...|    :.:|:.|.|::..:.:          :|.
Human   434 T------NSHGETVKTLYLSYLTV-LQKVANH----VALLQAASTSKQQETL----------IKR 477

  Fly   685 DVLAELDKFDETDSEDDCCDEEDSTRRDGNFKLEVIKDEIKEENVPWDSGDDLPTASSFEDQLDS 749
                             .||:                                 ..|.|.|.:..
Human   478 -----------------ICDQ---------------------------------VFSRFPDFVQK 492

  Fly   750 ARALKLLNPQNPIFQFIRPSAKLKMVIDKLEELLT---GTNDKIIVTSQWVSYLAIVRK--RLQD 809
            ::........:|.:     |.|:|:    |::||.   ...||:::.|.....|.::::  ....
Human   493 SKDAAFETLSDPKY-----SGKMKV----LQQLLNHCRKNRDKVLLFSFSTKLLDVLQQYCMASG 548

  Fly   810 LSWETLDFNGQLTAKEREIVLRDFNANNEKRVLLLSLTAGGVGLNLNVANHMLIVDLHWNPQLER 874
            |.:..||  |...::||..::::||:..:..:.|:|..|||:|||...||.:::.|..|||..:.
Human   549 LDYRRLD--GSTKSEERLKIVKEFNSTQDVNICLVSTMAGGLGLNFVGANVVVLFDPTWNPANDL 611

  Fly   875 QAQDRIYRYGQTKPTFIYRYMCQDTVEQRIKSLQDCKLEIAKVVLPEEGGE 925
            ||.||.||.||.:...:.|.:...|||:.:...|..|.::..||:..|..:
Human   612 QAIDRAYRIGQCRDVKVLRLISLGTVEEIMYLRQIYKQQLHCVVVGSENAK 662

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10445	NP_649751.2	HepA	<113..919	CDD:440319	162/837 (19%)
		DEAD-like_helicase_N	209..534	CDD:475120	70/350 (20%)
ERCC6L2	NP_064592.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23		5/21 (24%)
		Tudor_ERCC6L2	18..73	CDD:410471	12/63 (19%)
		HepA	<107..651	CDD:440319	161/811 (20%)
		DEXHc_ERCC6L2	123..371	CDD:350763	73/399 (18%)
		DEAH box	272..275		2/2 (100%)
		Atypical PIP-box. /evidence=ECO:0000269|PubMed:37014751	785..796
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	808..848
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	914..1002
		VIGSSK	<1118..1142	CDD:464308
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1354..1410