Protein Alignment CG10445 and Chd7

DIOPT Version :10

• Sequence 1: NP_649751.2
• Gene: CG10445 / 40938
• FlyBaseID: FBgn0037531
• Length: 945
• Species: Drosophila melanogaster
• Sequence 2: NP_001264078.1
• Gene: Chd7 / 320790
• MGIID: 2444748
• Length: 2986
• Species: Mus musculus
• Alignment Length: 980
• Identity: 193/980 - (19%)
• Similarity: 330/980 - (33%)
• Gaps: 377/980 - (38%)

  Fly     5 SPSDTTEIHKQSCSIQDQSSVPVPDSSGE-INNWMEPEPVDSLELSGEYADNESAIFVSASEYN- 67
            |||:|::       .:.|.||   |:.|. :...|....|...:.|||..:.|. .:|....::
Mouse   772 SPSNTSQ-------SEQQESV---DAEGPVVEKIMSSRLVKKQKESGEEVEVEE-FYVKYKNFSY 825

  Fly    68 -----------EKKAQIDQLVQKILTMEQQQRQLEE--------NASETKELCDLKLHLEKLNAR 113
                       ||..:|.|.:::..:.:.|.:.|.|        :..|...:.|.   ....:.|
Mouse   826 LHCQWASVEDLEKDKRIQQKIKRFKSKQGQSKFLSEIEDDLFNPDYVEVDRIMDF---ARSTDDR 887

  Fly   114 LEALGEFL----------DTLRLREDQQEIKIEDNSELVDHTEQPKWSNLYSGLNRYRQKANHTA 168
            .|.:..:|          .|..|::|..:.|||:..:|:  :.:|:...:
Mouse   888 GEPVIHYLVKWCSLPYEDSTWELKQDIDQTKIEEFEKLM--SREPETERV--------------- 935

  Fly   169 AQFYQHKSNIIDSLKTLYEPIQPRPAIDDLEKQPALLLV----RLLKHQQSCLKWMQFRERQKIS 229
                                  .||..||.:|..:....    :|.::|...:.|:.| ....:.
Mouse   936 ----------------------ERPPADDWKKSESSREYKNNNKLREYQLEGVNWLLF-NWYNMR 977

  Fly   230 GGILADDMGLGKTLSMIALILASEETKNRKREEKKKALTLKWTQEFNRVYCKEIRKISMFDDEEE 294
            ..||||:||||||:..|..:.                          .:|.|.|
Mouse   978 NCILADEMGLGKTIQSITFLY--------------------------EIYLKGI----------- 1005

  Fly   295 SGKEEEQYEPPEKRTCHVKTKKINQFRILDDDDNDAGDKAVVEDEQKDLLAKTPEPEVFSSDEEE 359
                                                                             
Mouse  1006 ----------------------------------------------------------------- 1005

  Fly   360 EHLSNGRYPSANTLVVCPMSVMCQWAHEVASKVAQNAIRVLTFHGPNRHEIGIEAFRSY------ 418
                :|.:     ||:.|:|.:..|..|..:....|   |:.:||.......|:.:..|
Mouse  1006 ----HGPF-----LVIAPLSTIPNWEREFRTWTELN---VVVYHGSQASRRTIQLYEMYFKDPQG 1058

  Fly   419 ---------DLVITSYNLVVNELKRYGNTSPLFAVYWNRVILDEAHIIRNSKTNCCNSVCQLRAH 474
                     ..:||::.:::.:.....|      :.|..|::||||.::|........:..:...
Mouse  1059 RVIKGSYKFHAIITTFEMILTDCPELRN------IPWRCVVIDEAHRLKNRNCKLLEGLKMMDLE 1117

  Fly   475 CHWALTGTPVQNRGVDVFALLRFVNVPNFQD----LQQWKKNLNESMLGHRRLNFIIKPLMLRRT 535
            ....|||||:||...::|:||.|:....|..    :|::.....|..:  ::|..|:||:||||.
Mouse  1118 HKVLLTGTPLQNTVEELFSLLHFLEPSRFPSETTFMQEFGDLKTEEQV--QKLQAILKPMMLRRL 1180

  Fly   536 KQKLQASGDMPALPSLKIELICVQLSKTEMAVYQILSAISKKIFTQFLLQREKGNSDLNYYSLER 600
            |:.::.:     |...:..:|.|:|:..:...|:   ||.:|.|| ||   .||....|..:|..
Mouse  1181 KEDVEKN-----LAPKEETIIEVELTNIQKKYYR---AILEKNFT-FL---SKGGGQANVPNLLN 1233

  Fly   601 TPQFIAGHMSDERYNEIYERFLKSLGYNPGEKILGIYILVLLLRLRQFCCHPGLMIGMLRGALTA 665
            |                                        ::.||:.|.||.|:.|
Mouse  1234 T----------------------------------------MMELRKCCNHPYLING-------- 1250

  Fly   666 EDVQNVKVDASDVEGQLKMDVLAELDKFDETDSEDDCCDEEDSTRRDGNFKLEVIKDEIKEENVP 730
                                  ||                            |.|.:|.||.:
Mouse  1251 ----------------------AE----------------------------EKILEEFKETH-- 1263

  Fly   731 WDSGDDLPTASSFEDQLDSARALKLLNPQNPIFQ---FIRPSAKLKMVIDKLEELLTGTNDKIIV 792
                                      |.::|.||   .|:.:.|| ::||||...|.....::::
Mouse  1264 --------------------------NAESPDFQLQAMIQAAGKL-VLIDKLLPKLKAGGHRVLI 1301

  Fly   793 TSQWVSYLAIVRKRL--QDLSWETLDFNGQLTAKEREIVLRDFN-ANNEKRVLLLSLTAGGVGLN 854
            .||.|..|.|:...|  :...:|.:|  |::....|:..:..|: .::::.|.||...|||:|:|
Mouse  1302 FSQMVRCLDILEDYLIQRRYPYERID--GRVRGNLRQAAIDRFSKPDSDRFVFLLCTRAGGLGIN 1364

  Fly   855 LNVANHMLIVDLHWNPQLERQAQDRIYRYGQTKPTFIYRYMCQDTVEQRIKSLQDCKLEIAKVVL 919
            |..|:..:|.|..||||.:.|||.|.:|.||:|...|||.:.:::.|:.:......||.:.|.||
Mouse  1365 LTAADTCIIFDSDWNPQNDLQAQARCHRIGQSKSVKIYRLITRNSYEREMFDKASLKLGLDKAVL 1429

  Fly   920 PEEGG 924
            ....|
Mouse  1430 QSMSG 1434

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10445	NP_649751.2	HepA	<113..919	CDD:440319	165/844 (20%)
		DEAD-like_helicase_N	209..534	CDD:475120	61/343 (18%)
Chd7	NP_001264078.1	Glutenin_hmw	<23..553	CDD:367362
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	93..146
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	159..180
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	194..246
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	261..307
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	372..412
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	461..792		9/29 (31%)
		CD1_tandem_CHD5-9_like	786..850	CDD:349315	13/64 (20%)
		CD2_tandem_CHD5-9_like	869..926	CDD:349310	11/59 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	928..949		6/57 (11%)
		PLN03142	957..>1556	CDD:215601	152/742 (20%)
		DEAH box	1095..1098		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1566..1590
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1826..1851
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2151..2274
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2366..2393
		BRK	2552..2593	CDD:462196
		BRK	2631..2675	CDD:197800
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2812..2861
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2924..2986