Protein Alignment CG10445 and Ercc6

DIOPT Version :10

• Sequence 1: NP_649751.2
• Gene: CG10445 / 40938
• FlyBaseID: FBgn0037531
• Length: 945
• Species: Drosophila melanogaster
• Sequence 2: NP_001074690.1
• Gene: Ercc6 / 319955
• MGIID: 1100494
• Length: 1481
• Species: Mus musculus
• Alignment Length: 976
• Identity: 186/976 - (19%)
• Similarity: 312/976 - (31%)
• Gaps: 395/976 - (40%)

  Fly    15 QSCSIQDQSSVPVPDSSGEINNWMEPE-------------PVDSLELSGEYADNESAIFVSASE- 65
            |..::|.|..|.:|.....:...:.||             |.|. |...|..:.|....:|:.:
Mouse   336 QRRALQFQGKVGLPSGKKPLEPEVRPEAEGDTEGEESGSSPTDG-EEEEEQEEEEGVASLSSDDV 399

  Fly    66 -YNEKKAQIDQLVQKILTMEQQQRQLEENASETKELCD-------------------LKLHLEKL 110
             |..|..:..|..||.:.:::.......::.|..|..:                   .|..|.:.
Mouse   400 SYELKPLRKRQKYQKKVPVQEIDDDFFPSSEEEDEAMEGRGGGRKVARRQDDGDEDYYKQRLRRW 464

  Fly   111 NARLEALGEFLDTLRLREDQQEIKIEDNSELVDHTEQPKWSNLYSGLNRYRQKANHTAAQFYQHK 175
            |           .|||::.::.:|:||:||..|                         |:|
Mouse   465 N-----------RLRLQDKEKRLKLEDDSEESD-------------------------AEF---- 489

  Fly   176 SNIIDSLKTLYEPIQPRPAIDDLEKQPALLLVRLLKHQQSCLKWMQFRERQKISGGILADDMGLG 240
                                |:..|.|..|..:|.|:||:.::|:.....|: :||||.|:||||
Mouse   490 --------------------DEGFKVPGFLFKKLFKYQQTGVRWLWELHCQQ-AGGILGDEMGLG 533

  Fly   241 KTLSMIALILASEETKNRKREEKKKALTLKWTQEFNRVYCKEIRKISMFDDEEESGKEEEQYEPP 305
            ||:.:||.:.....:|.|.|.
Mouse   534 KTIQIIAFLAGLSYSKIRTRG-------------------------------------------- 554

  Fly   306 EKRTCHVKTKKINQFRILDDDDNDAGDKAVVEDEQKDLLAKTPEPEVFSSDEEEEHLSNGRYPSA 370
                                                                     ||.|:...
Mouse   555 ---------------------------------------------------------SNYRFEGL 562

  Fly   371 N-TLVVCPMSVMCQWAHEVASKVAQNAIRVLTFHGPNRHEIGIEAFRS----------YDLVITS 424
            . |::|||.:||.||..|..:......:.||       ||.|....:.          :.::|||
Mouse   563 GPTIIVCPTTVMHQWVKEFHTWWPPFRVAVL-------HETGSYTHKKERLIRDIVYCHGVLITS 620

  Fly   425 YN---LVVNELKRYGNTSPLFAVYWNRVILDEAHIIRNSKTNCCNSVCQLRAHCHWALTGTPVQN 486
            |:   |:.:::.|:.         |:.|||||.|.|||.......:..|.|......|:|:|:||
Mouse   621 YSYIRLMQDDISRHD---------WHYVILDEGHKIRNPNAAVTLACKQFRTPHRIILSGSPMQN 676

  Fly   487 RGVDVFALLRFV------NVPNFQDLQQWKKNLNESMLGHRR---------------LNFIIKPL 530
            ...::::|..|:      .:|.|  ::|:...:  :|.|:..               |...|.|.
Mouse   677 NLRELWSLFDFIFPGKLGTLPVF--MEQFSVPI--TMGGYSNASPVQVKTAYKCACVLRDTINPY 737

  Fly   531 MLRRTKQKLQASGDMPALPSLKIELICVQLSKTEMAVYQILSAISKKIFTQFLLQREKGNSDLNY 595
            :|||.|..::.|..:|              .|.|..::..|:....|::..|:      :|...|
Mouse   738 LLRRMKSDVKMSLSLP--------------DKNEQVLFCRLTDEQHKVYQNFI------DSKAVY 782

  Fly   596 YSLERTPQFIAGHMSDERYNEIYERFLKSLGYNPGEKILGIYILVLLLRLRQFCCHPGLMIGMLR 660
            ..|....|..:|                                  |:.||:.|.||.|..|..:
Mouse   783 RILNGENQIFSG----------------------------------LVALRKICNHPDLFSGGPK 813

  Fly   661 GALTAEDVQNVKVDASDVEGQLKMDVLAELDKFDETDSEDDCCDEEDSTRRDGNFKLEVIKDEIK 725
            .|....:                                                      ||::
Mouse   814 NASGPPE------------------------------------------------------DELE 824

  Fly   726 EENVPWDSGDDLPTASSFEDQLDSARALKLLNPQNPIFQFIRPSAKLKMVIDKLEELLTGTNDKI 790
            ||.                                  |...|.|.|: :|::.|.::......::
Mouse   825 EEQ----------------------------------FGHWRRSGKM-IVVESLLKIWHRQGQRV 854

  Fly   791 IVTSQWVSYLAIVRKRLQDLSWETLDFNGQLTAKEREIVLRDFNANNEKRVLLLSLTAGGVGLNL 855
            ::.||....|.|:...|:...:..|..:|..|...|:.::..:|.:....|.||:...||:|:||
Mouse   855 LLFSQSRQMLHILEVFLRAHKYSYLKMDGTTTIASRQPLITKYNEDTSIFVFLLTTRVGGLGVNL 919

  Fly   856 NVANHMLIVDLHWNPQLERQAQDRIYRYGQTKPTFIYRYMCQDTVEQRIKSLQDCKLEIAKVVLP 920
            ..||.::|.|..|||..:.||::|.:|.||.|...:||.:...|:|::|...|..|..:...||.
Mouse   920 TGANRVIIYDPDWNPSTDTQARERAWRIGQKKQVTVYRLLTAGTIEEKIYHRQIFKQFLTNRVLK 984

  Fly   921 E 921
            :
Mouse   985 D 985

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10445	NP_649751.2	HepA	<113..919	CDD:440319	161/840 (19%)
		DEAD-like_helicase_N	209..534	CDD:475120	73/359 (20%)
Ercc6	NP_001074690.1	N-terminal domain, essential for its chromatin remodeling activity. /evidence=ECO:0000250|UniProtKB:Q03468	1..506		39/230 (17%)
		cc_ERCC-6_N	83..159	CDD:411064
		46	<122..>199	CDD:222878
		HepA	280..983	CDD:440319	184/972 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	309..452		20/116 (17%)
		DEAH box. /evidence=ECO:0000255|PROSITE-ProRule:PRU00541	642..645		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1040..1096
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1114..1238
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1307..1372
		CSA-interacting motif (CIM). /evidence=ECO:0000250|UniProtKB:Q03468	1373..1385
		Ubiquitin-binding domain (UBD). /evidence=ECO:0000250|UniProtKB:Q03468	1387..1416
		CSB_WHD	1410..1480	CDD:439329
		Winged-helix domain (WHD). /evidence=ECO:0000250|UniProtKB:Q03468	1417..1481
		Essential for its interaction with RNA polymerase II, transcription-coupled nucleotide excision repair activity, association with chromatin after UV irradiation and for mediating the UV-induced translocation of ERRC8 to the nuclear matrix. /evidence=ECO:0000250|UniProtKB:Q03468	1434..1481