Protein Alignment CG10445 and HELLS

DIOPT Version :10

• Sequence 1: NP_649751.2
• Gene: CG10445 / 40938
• FlyBaseID: FBgn0037531
• Length: 945
• Species: Drosophila melanogaster
• Sequence 2: NP_001275996.1
• Gene: HELLS / 3070
• HGNCID: 4861
• Length: 884
• Species: Homo sapiens
• Alignment Length: 1042
• Identity: 213/1042 - (20%)
• Similarity: 365/1042 - (35%)
• Gaps: 396/1042 - (38%)

  Fly    67 NEKKAQIDQLVQKILT--MEQQQRQLEENASETKELCDLKLHLEKLNARLEALGEFLDTLRLRED 129
            :|..|.::||...::|  |.:::.|||.                   |.||...:.|:..|:..|
Human    12 SEAPAMVEQLDTAVITPAMLEEEEQLEA-------------------AGLERERKMLEKARMSWD 57

  Fly   130 QQEIKIEDNSELVDHTEQPKWSNLYSGLNRYRQKANHTAAQFYQHKSNIIDSLKTLYEPIQPRPA 194
            ::..:|                       |||:      .|....||||...
Human    58 RESTEI-----------------------RYRR------LQHLLEKSNIYSK------------- 80

  Fly   195 IDDLEKQPALLLVRLLKHQQSCLKWMQFRERQKISGGILADDMGLGKTLSMIALILASEETKNRK 259
                     .||.::              |:|::                       .|:.|..|
Human    81 ---------FLLTKM--------------EQQQL-----------------------EEQKKKEK 99

  Fly   260 REEKKKALTLKWTQEFNRVYCKEIRKISMFDDEEESGKEEEQY------EPPEKRTCHVKTKKIN 318
            .|.||::|.:|  :..|.:...|.:.:.    .::.|:|:|.|      ...|..:...|.||.|
Human   100 LERKKESLKVK--KGKNSIDASEEKPVM----RKKRGREDESYNISEVMSKEEILSVAKKNKKEN 158

  Fly   319 QFRILDDDDNDAGDKAVVEDEQ---------KDLLAKT----------------PEPEVFSSDEE 358
                  :|:|.:.....|||.|         ||.|::|                .:|..|   ::
Human   159 ------EDENSSSTNLCVEDLQKNKDSNSIIKDRLSETVRQNTKFFFDPVRKCNGQPVPF---QQ 214

  Fly   359 EEHLSNG----------------------------------------------RYPSANTLVVCP 377
            .:|.:.|                                              |......||..|
Human   215 PKHFTGGVMRWYQVEGMEWLRMLWENGINGILADEMGLGKTVQCIATIALMIQRGVPGPFLVCGP 279

  Fly   378 MSVMCQWAHEVASKVAQNAIRVLTFHG--PNRHEIGIEAFRS------YDLVITSYNLVVNELKR 434
            :|.:..|..|.  |.....|..:.:||  ..|.::....::.      :.:||||:.:.:.:
Human   280 LSTLPNWMAEF--KRFTPDIPTMLYHGTQEERQKLVRNIYKRKGTLQIHPVVITSFEIAMRD--- 339

  Fly   435 YGNTSPLFAVYWNRVILDEAHIIRNSKTNCCNSVCQLRAHCHWALTGTPVQNRGVDVFALLRFVN 499
               .:.|...||..:|:||.|.|:|.|......:.:..|.....|||||:||...::::||.|:.
Human   340 ---RNALQHCYWKYLIVDEGHRIKNMKCRLIRELKRFNADNKLLLTGTPLQNNLSELWSLLNFLL 401

  Fly   500 VPNFQDLQQWKKNLNESMLGHRRLNFIIKPLMLRRTKQKLQASGDMPALPSLKIELICVQLSKTE 564
            ...|.||:.::...:                                          ...||:|
Human   402 PDVFDDLKSFESWFD------------------------------------------ITSLSET- 423

  Fly   565 MAVYQILSAISKKIFTQFLLQREKGNSDLNYYSLERTPQFIAGHMSDERYNEIYERFLKSLGYNP 629
                           .:.::.:|:..:.|:....||.|:......:||.:.|         |..|
Human   424 ---------------AEDIIAKEREQNVLHMLHQERIPRMYVSEFTDEGFFE---------GKLP 464

  Fly   630 GEKIL-------GIYILVLLLRLRQFCCHPGLMIGMLRGALTAEDVQNVKVD-ASDVEGQLKMDV 686
            ..|.|       ..|:|.|         |....|      ||...::.:|.| |.:|..:.::.|
Human   465 SRKDLYDIRPYENTYLLKL---------HTNFEI------LTPFLLRRLKSDVALEVPPKREVVV 514

  Fly   687 LAELDKFDET---------------DSEDDCCD------EEDSTRRDGNF-KLEVIKDEIKEENV 729
            .|.|.|..|.               .||.:..:      .:..||:..|: |::...:|:::
Human   515 YAPLSKKQEIFYTAIVNRTIANMFGSSEKETIELSPTGRPKRRTRKSINYSKIDDFPNELEK--- 576

  Fly   730 PWDSGDDLPTASSFEDQLDSARA-------------LKLLN-----------------PQNPIFQ 764
                     ..|..:.::|..||             |||.|                 |.:|:.|
Human   577 ---------LISQIQPEVDRERAVVEVNIPVESEVNLKLQNIMMLLRKCCNHPYLIEYPIDPVTQ 632

  Fly   765 -------FIRPSAKLKMVIDKLEELLTGTNDKIIVTSQWVSYLAIVRK--RLQDLSWETLDFNGQ 820
                   .:..|.|. :::|::...|.....|:::.||..|.|.|:..  .|:|.::..||  |.
Human   633 EFKIDEELVTNSGKF-LILDRMLPELKKRGHKVLLFSQMTSMLDILMDYCHLRDFNFSRLD--GS 694

  Fly   821 LTAKEREIVLRDFNANNEKRVLLLSLTAGGVGLNLNVANHMLIVDLHWNPQLERQAQDRIYRYGQ 885
            ::..|||..:..||.:.|..:.|:|..|||:|:||..|:.::|.|..||||.:.|||||.:|.||
Human   695 MSYSEREKNMHSFNTDPEVFIFLVSTRAGGLGINLTAADTVIIYDSDWNPQSDLQAQDRCHRIGQ 759

  Fly   886 TKPTFIYRYMCQDTVEQRIKSLQDCKLEIAKVVLPE---EGGEVTKCVGGGLNLA----ELKKLF 943
            |||..:||.:..:|::|:|......|.::.|:::.:   :||:      .||||:    :.|:|.
Human   760 TKPVVVYRLVTANTIDQKIVERAAAKRKLEKLIIHKNHFKGGQ------SGLNLSKNFLDPKELM 818

  Fly   944 EM 945
            |:
Human   819 EL 820

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10445	NP_649751.2	HepA	<113..919	CDD:440319	194/959 (20%)
		DEAD-like_helicase_N	209..534	CDD:475120	75/409 (18%)
HELLS	NP_001275996.1	DEXHc_HELLS_SMARCA6	220..499	CDD:350767	63/368 (17%)
		PLN03142	221..>869	CDD:215601	153/711 (22%)