DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10445 and Hltf

DIOPT Version :9

Sequence 1:	NP_001246974.1	Gene:	CG10445 / 40938	FlyBaseID:	FBgn0037531	Length:	945	Species:	Drosophila melanogaster
Sequence 2:	XP_006232237.1	Gene:	Hltf / 295568	RGDID:	1309031	Length:	1018	Species:	Rattus norvegicus

Alignment Length:	1046	Identity:	246/1046 - (23%)
Similarity:	416/1046 - (39%)	Gaps:	290/1046 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 SGEINN----WMEPEPVDSLELSGEYADNESAIFVSASEYNEKKAQIDQLVQKILTMEQQQRQLE 91
            :|.:||    .:|.||.:..:.:....:|     |:.::....|..:...:..|  |:.:..|:|
  Rat    74 TGVVNNNEMVALEREPNNPYDKNAIKVNN-----VNGNQVGHLKRDLAAALAYI--MDNKLAQVE 131

  Fly    92 E----NASETKELCDLKLHLEKLNARLEALGEFLDTLRLREDQQEIKIEDNSELVDHTEQ----- 147
            .    .||.|   ..:.||:               |...:|:.:|:       ::||.::
  Rat   132 GVVPFGASNT---FTMPLHM---------------TFWGKEENREV-------VLDHLKKHGFKL 171

  Fly   148 ---PK---------WSNLYSGLNRYRQKANHTAAQFYQHKSNIIDSLKTLYEPIQPRPAIDD--L 198
               ||         |.:..:|.:..|..  |.|.|.      ..:.|||.::.:......||  :
  Rat   172 GPTPKTVGSSLENTWGSGRAGPSYSRPV--HVAVQM------TTEQLKTEFDKLFEDLKEDDRTI 228

  Fly   199 EKQPA-LLLVRLLKHQQSCLKWMQFRERQK----------------------------ISGGILA 234
            |.:|| .:...||.||:..|.||..||..|                            :.|||||
  Rat   229 EMEPAEAVETPLLPHQKQALAWMIARENSKELPPFWELRNDLYYNTITNFSVKERPENVHGGILA 293

  Fly   235 DDMGLGKTLSMIALILASEET------KNRK-----REEKKKALTLKWT---------------- 272
            |||||||||:.||:||.:.:.      |..|     :|.|.:.:.|:.:
  Rat   294 DDMGLGKTLTAIAVILTNFDDGRPLLGKRGKESHPGKEYKDETVKLRGSNTNKTTDGHSEPSACS 358

  Fly   273 --------QEFNRV-----YCKEIRKISMFDDEEESGKEEEQYEPPEKRTCHVKTKKINQFRILD 324
                    .|.:.|     :..:.||||:...|....:|.|..:..:|....:|..:      ||
  Rat   359 EEPSISDVSEKSNVSDLFSFFSKRRKISVQSTESSESEEIETSKLSQKMKGKLKNTQ------LD 417

  Fly   325 DDDNDAGDKAVVEDEQ-------------KDLLAKTPEPEVFSSDEEEEHLSNGRYPSANTLVVC 376
            ......|...:.||.|             |.:|.|..     |..|..:....|. .:..||::|
  Rat   418 TKSKVKGSSKIKEDTQFALALTYFGPATKKKMLKKGT-----SVMESSKKCDTGE-RTRTTLIIC 476

  Fly   377 PMSVMCQW-------------------AHEVASKVAQNAIRVLTFHGPNRHEIGIEAFRS-YDLV 421
            |:||:..|                   ...:.|:|..|   :..::||:|  |....:.| .|::
  Rat   477 PLSVLSNWILFSLISLRFFMKYTQDQIGQHIKSEVDLN---LYVYYGPDR--IRDSTWLSKQDII 536

  Fly   422 ITSYNLVVNELKRYG--NTSPLFAVYWNRVILDEAHIIRNSKTNCCNSVCQLRAHCHWALTGTPV 484
            :|:||::.::   ||  :.|||.::.|.||||||.|.|||.......:|.:|.|...|.|||||:
  Rat   537 LTTYNILTHD---YGTKDNSPLHSIKWLRVILDEGHAIRNPNAQQTKAVLELEAERRWVLTGTPI 598

  Fly   485 QNRGVDVFALLRFVNVPNFQDLQQWKKNLNESML-----GHRRLNFIIKPLMLRRTKQKLQASGD 544
            ||...|:::||.|:.:..|.|.:.|.:.:...:.     |.|||..:||.:.|||||........
  Rat   599 QNSLKDLWSLLSFLKLKPFTDREWWHRIIQRPVTTGDEGGLRRLQSLIKSITLRRTKTSKIKGKP 663

  Fly   545 MPALPSLKIELICVQLSKTEMAVYQILSAISKKIFTQFLLQREKGNSDLNYYSLERTPQFIAGHM 609
            :..||..|:.:..:.||..|..:||.:              :.:|.:.:..|..|.|   :..|.
  Rat   664 VLELPERKVFIQHITLSVEERKIYQSV--------------KNEGKATIARYFTEGT---VLAHY 711

  Fly   610 SDERYNEIYERFLKSLGYNPGEKILGIYILVLLLRLRQFCCHPGLMIGMLRGALTAEDVQNVKVD 674
            :|                          :|.|||||||.|||    :.:.....::.|...
  Rat   712 AD--------------------------VLGLLLRLRQICCH----VHLPTNGTSSSDPSR---- 742

  Fly   675 ASDVEGQLKMDVLAELDKFDETDSEDDC----------------------CDEEDSTRRDGNFKL 717
             ||...:|:..::.::.....:.|:::|                      |..:...|...:.|.
  Rat   743 -SDTPEELRKMLVTKMKLILSSGSDEECSICLDSLTFPVITHCAHVFCKPCICQVIQREQPHAKC 806

  Fly   718 EVIKDEIKEENVPWDSGDDLPTASSFEDQLDSARALKLLNPQNPIFQFIRPSAKLKMVIDKLEEL 782
            .:.:..|...|:.....::|...|..:..::..                 .|:|:..:::.|.||
  Rat   807 PLCRSNIHGHNLLECPPEELACDSDNKSDMEWT-----------------SSSKINALMNALIEL 854

  Fly   783 LT-GTNDKIIVTSQWVSYLAIVRKRLQDLSWETLDFNGQLTAKEREIVLRDFNANN--EKRVLLL 844
            .| ..|.|.:|.||:.::|:::...|:...:.....:|.:..|:|...::.|...:  ...::||
  Rat   855 RTKDPNIKSLVVSQFTTFLSLIETPLKASGFVFTRLDGSMAQKKRVESIQCFQNTDAGSPTIMLL 919

  Fly   845 SLTAGGVGLNLNVANHMLIVDLHWNPQLERQAQDRIYRYGQTKPTFIYRYMCQDTVEQRIKSLQD 909
            ||.||||||||..|:.:.::|..|||..|.|..||.:|.||.:...|.:::.:|:||:.:..:|:
  Rat   920 SLKAGGVGLNLCAASRVFLMDPAWNPAAEDQCFDRCHRLGQKQEVIITKFIVKDSVEENMLKIQN 984

  Fly   910 CKLEIA 915
            .|.|:|
  Rat   985 MKRELA 990

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10445	NP_001246974.1	HepA	<90..945	CDD:223627	234/983 (24%)
CG10445	NP_001246974.1	DEAD-like_helicase_N	209..534	CDD:421690	116/432 (27%)
Hltf	XP_006232237.1	HIRAN	60..155	CDD:285949	19/105 (18%)
		DEXDc	238..>316	CDD:214692	28/77 (36%)
		SNF2_N	472..727	CDD:278600	87/305 (29%)
		DEXDc	<472..597	CDD:238005	42/132 (32%)
		RING	768..813	CDD:238093	4/44 (9%)
		Helicase_C	841..959	CDD:278689	39/117 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D132523at2759
OrthoFinder	1	1.000	-	-		FOG0000507
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101296
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820