DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10445 and Ttf2

DIOPT Version :9

Sequence 1:	NP_001246974.1	Gene:	CG10445 / 40938	FlyBaseID:	FBgn0037531	Length:	945	Species:	Drosophila melanogaster
Sequence 2:	NP_001099924.2	Gene:	Ttf2 / 295324	RGDID:	1309145	Length:	1142	Species:	Rattus norvegicus

Alignment Length:	988	Identity:	283/988 - (28%)
Similarity:	455/988 - (46%)	Gaps:	232/988 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 IHKQSCSIQDQSSVPVPDSSGEINNWMEPEPVDSLELSGEYADNESAIFVSASEYNEKKAQIDQL 76
            :|..:.|..|......|.|....:..::.:...||:.|.:....::|   :||..::|....|..
  Rat   329 VHHATSSSDDSEDDGRPGSPLLFDLTIDSQKKGSLQHSDQSVQRQTA---AASGVSKKGESSDLA 390

  Fly    77 VQKI-LTMEQQQRQLEENASETKELCDLKLHLEKLNARLEALGEFLDTLRLREDQ---------- 130
            .|:. ||.:.:|::....|...:.|.|..   |||..:::||.:.|:.|.|..:|
  Rat   391 AQRANLTTQLKQKKGTLAAVNIQALPDKG---EKLLKQIQALEDALNALALSPEQGTRENCSSQE 452

  Fly   131 -QEIKIEDNS-----ELVDHTEQPK-----WSNLYSGLNRYRQKANHTAAQ-----FYQHK---- 175
             ::.|:.:.:     .||.....|:     .::|  ||...||:....|:|     ..:|:
  Rat   453 PEQSKVTETAAAGPLHLVPPQPLPRPHIQPAASL--GLKASRQETPEGASQCSGGHTNEHRLYNV 515

  Fly   176 ----SNIIDSLKTLYEPIQPRPAIDDLEKQPALLLVRLLKHQQSCLKWMQFRERQKISGGILADD 236
                |..||.   |:..::..|....:.:.||.|.|.||.||:..|.|:.:||.||..|||||||
  Rat   516 WKITSEAIDE---LHRSLESCPGKTAVAEDPAGLKVPLLLHQKQALAWLLWRESQKPQGGILADD 577

  Fly   237 MGLGKTLSMIALILASEETKNRKREEKKKALTLKWTQEFNRVYCKEIRKISMFDDEEESGKEEEQ 301
            |||||||:||||||..:  ..:|.:||.::|.:.|..:
  Rat   578 MGLGKTLTMIALILTKK--NQQKSKEKDRSLPVMWLSK--------------------------- 613

  Fly   302 YEPPEKRTCHVKTKKINQFRILDDDDNDAGDKAVVEDEQKDLLAKTPEPEVFSSDEEEEHLSNGR 366
                                      ||:                    .||:
  Rat   614 --------------------------NDS--------------------SVFT------------ 620

  Fly   367 YPSANTLVVCPMSVMCQWAHEVASKVAQNAIRVLTFHGPNRHEIGIEAFRSYDLVITSYNLVVNE 431
              |..||:|||.|::..|.:|:..:|..|.:|:..:|||||.: ..:...:||:|||:|:|:..|
  Rat   621 --STGTLIVCPASLIHHWKNEIEKRVNSNKLRIYLYHGPNRIQ-HAKVLSTYDIVITTYSLLAKE 682

  Fly   432 --------------LKRYGNTSPLFAVYWNRVILDEAHIIRNSKTNCCNSVCQLRAHCHWALTGT 482
                          |...|.::||..|.|.|:||||||.::|.:.....:||:|:|...||:|||
  Rat   683 IPTAKHEGEVPGAKLSVEGISAPLLQVVWARIILDEAHNVKNPRVQTSIAVCKLQAQARWAVTGT 747

  Fly   483 PVQNRGVDVFALLRFVNVPNFQDLQQWKKNL-NESMLGHRRLNFIIKPLMLRRTKQKLQASG-DM 545
            |:||..:|:::|::|:....|.:...||..: |.||.|..||:.:.|.|:|||||.:|.::| .:
  Rat   748 PIQNNLLDMYSLMKFLRCSPFDEFSLWKSQVDNGSMKGGERLSILTKSLLLRRTKDQLDSTGKPL 812

  Fly   546 PALPSLKIELICVQLSKTEMAVYQILSAISKKIFTQFLLQREKGNSDLNYYSLERTPQFIAGHMS 610
            ..||:...:|..::||:.|.|||.:..|.|:.....:|.::|...|...     |:|:.....::
  Rat   813 VPLPARSCQLHRLKLSEDERAVYDVFLARSRSALQSYLKRQEGRGSHPG-----RSPENPFSRVA 872

  Fly   611 DERYNEIYERFLKSLGYNPGEKILGIYILVLLLRLRQFCCHPGLMIGMLRGALTAEDVQNVKVDA 675
            .|..:.:.:....:....|..    :::|..||||||.|||    :.:|:..|..:::::..:..
  Rat   873 QEFGSGVPQCSTAADSRRPST----VHVLSQLLRLRQCCCH----LSLLKSVLDPKELESEGLVL 929

  Fly   676 SDVEGQLKMDVLAELDKFD--ETDSEDDCCDEEDSTRRDGNFKLEVIKDEIKEENVPWDSGDDLP 738
            | :|.||....|:::|..:  .|.|.:..|           ||:|:..|
  Rat   930 S-LEEQLSALTLSKVDVSEPSPTVSLNGTC-----------FKVELFDD---------------- 966

  Fly   739 TASSFEDQLDSARALKLLNPQNPIFQFIRPSAKLKMVIDKLEELLTGT-NDKIIVTSQWVSYLAI 802
                                       ||.|.|:..::.:||.:..|. :.|.::.|||.|.|.:
  Rat   967 ---------------------------IRRSTKVSSLLAELEAIQKGPGSQKSVIVSQWTSMLQV 1004

  Fly   803 VRKRLQD--LSWETLDFNGQLTAKEREIVLRDFNANNEKRVLLLSLTAGGVGLNLNVANHMLIVD 865
            |...|:.  |::.|:|  |.:..|:|..::..||.:...:|:|:||.||||||||...||:.::|
  Rat  1005 VALHLRKNRLTYATID--GSVNPKQRMDLVEAFNHSQGPQVMLISLLAGGVGLNLTGGNHLFLLD 1067

  Fly   866 LHWNPQLERQAQDRIYRYGQTKPTFIYRYMCQDTVEQRIKSLQDCKLEIAKVVLPEEGGEVTKCV 930
            :||||.||.||.|||||.||.|...::|::|:.|||::|..||:.|.::||.||...||.|||
  Rat  1068 MHWNPSLEDQACDRIYRVGQEKDVVMHRFVCEGTVEEKILQLQEKKKDLAKQVLSGSGGPVTK-- 1130

  Fly   931 GGGLNLAELKKLF 943
               |.||:||.||
  Rat  1131 ---LTLADLKILF 1140

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10445	NP_001246974.1	HepA	<90..945	CDD:223627	266/909 (29%)
CG10445	NP_001246974.1	DEAD-like_helicase_N	209..534	CDD:421690	105/339 (31%)
Ttf2	NP_001099924.2	zf-GRF	6..44	CDD:284302
		Sec_Non_Glob	<166..307	CDD:275213
		SNF2_N	553..913	CDD:278600	137/462 (30%)
		DEXDc	570..748	CDD:238005	76/267 (28%)
		Helicase_C	970..1086	CDD:278689	49/117 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	249	1.000	Domainoid score	I2059
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D132523at2759
OrthoFinder	1	1.000	-	-		FOG0000507
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45626
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1278
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	8.020