Protein Alignment CG10445 and CHD5

DIOPT Version :10

• Sequence 1: NP_649751.2
• Gene: CG10445 / 40938
• FlyBaseID: FBgn0037531
• Length: 945
• Species: Drosophila melanogaster
• Sequence 2: NP_056372.1
• Gene: CHD5 / 26038
• HGNCID: 16816
• Length: 1954
• Species: Homo sapiens
• Alignment Length: 723
• Identity: 154/723 - (21%)
• Similarity: 266/723 - (36%)
• Gaps: 226/723 - (31%)

  Fly   249 ILASEETKNRKREEKKKALTLKWTQEFNRVYCKEIRKISMFDDEEESGKEEEQYEPPEK------ 307
            ::..|:|:..||..||.               |::|     ||::|...:....:|..|
Human   647 LMLGEDTRLPKRLLKKG---------------KKLR-----DDKQEKPPDTPIVDPTVKFDKQPW 691

  Fly   308 ------RTCH-VKTKKINQFRILDDDDNDAGDKAVVEDEQKDLLAKTPEPEVFSSDEEEEHLSNG 365
                  .|.| .:.:.:|..|.    ....|...::.||..  |.||.:..||.....:|..|.|
Human   692 YIDSTGGTLHPYQLEGLNWLRF----SWAQGTDTILADEMG--LGKTVQTIVFLYSLYKEGHSKG 750

  Fly   366 RYPSANTLVVCPMSVMCQWAHE-------------VASKVAQNAIRVLTF-HGPNRHEIGIEAFR 416
            .|     ||..|:|.:..|..|             ...|.:::.||...| ...|....|.:.||
Human   751 PY-----LVSAPLSTIINWEREFEMWAPDFYVVTYTGDKESRSVIRENEFSFEDNAIRSGKKVFR 810

  Fly   417 -------SYDLVITSYNLVVNELKRYGNTSPLFAVYWNRVILDEAHIIRNSKTNCCNSVCQLRAH 474
                   .:.:::|||.|:..:....|      ::.|..:::||||.::|:::.....:...:..
Human   811 MKKEVQIKFHVLLTSYELITIDQAILG------SIEWACLVVDEAHRLKNNQSKFFRVLNSYKID 869

  Fly   475 CHWALTGTPVQNRGVDVFALLRFVNVPNFQDLQQWKKNL----NESMLGHRRLNFIIKPLMLRRT 535
            ....|||||:||...::|.||.|:....|.:|:.:.:..    .|..:  ::|:.::.|.||||.
Human   870 YKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEFADISKEDQI--KKLHDLLGPHMLRRL 932

  Fly   536 KQKLQASGDMPALPSLKIELICVQLSKTEMAVYQILSAISKKIFTQFLLQREKGNSDLNYYSLER 600
              |.....:|||              |||:.|...||.:.||.: :|:|.|.
Human   933 --KADVFKNMPA--------------KTELIVRVELSQMQKKYY-KFILTRN------------- 967

  Fly   601 TPQFIAGHMSDERYNEIYERFLKSLGYNPGEKILGIYILVLLLRLRQFCCHPGLMIGMLRGALTA 665
                             :|......|.|.      :.:|.:::.|::.|.||.|
Human   968 -----------------FEALNSKGGGNQ------VSLLNIMMDLKKCCNHPYL----------- 998

  Fly   666 EDVQNVKVDASDVEGQLKMDVLAELDKFDETDSEDDCCDEEDSTRRDGNFKLEVIKDEIKEENVP 730
                                                             |.:..::..:
Human   999 -------------------------------------------------FPVAAVEAPV------ 1008

  Fly   731 WDSGDDLPTASSFEDQLDSARALKLLNPQNPIFQFIRPSAKLKMVIDKLEELLTGTNDKIIVTSQ 795
                  ||..|.....|                  ::.|.|| |::.|:.:.|.....::::.||
Human  1009 ------LPNGSYDGSSL------------------VKSSGKL-MLLQKMLKKLRDEGHRVLIFSQ 1048

  Fly   796 WVSYLAIVRKRLQDLSWETLDFNGQLTAKEREIVLRDFNANNEKR-VLLLSLTAGGVGLNLNVAN 859
            ....|.::...|:...::....:|.:|...|:..:..|||...:: ..|||..|||:|:||..|:
Human  1049 MTKMLDLLEDFLEYEGYKYERIDGGITGGLRQEAIDRFNAPGAQQFCFLLSTRAGGLGINLATAD 1113

  Fly   860 HMLIVDLHWNPQLERQAQDRIYRYGQTKPTFIYRYMCQDTVEQRIKSLQDCKLEIAKVV----LP 920
            .::|.|..|||..:.||..|.:|.||.|...|||::.:.:||:||..:...|:.:..:|    |.
Human  1114 TVIIYDSDWNPHNDIQAFSRAHRIGQNKKVMIYRFVTRASVEERITQVAKRKMMLTHLVVRPGLG 1178

  Fly   921 EEGGEVTK 928
            .:.|.:||
Human  1179 SKSGSMTK 1186

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10445	NP_649751.2	HepA	<113..919	CDD:440319	150/712 (21%)
		DEAD-like_helicase_N	209..534	CDD:475120	72/322 (22%)
CHD5	NP_056372.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..134
		CHDNT	145..200	CDD:462357
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	225..338
		Histone-binding	343..653		1/5 (20%)
		PHD1_CHD_II	345..387	CDD:277006
		PHD2_CHD_II	418..460	CDD:277007
		CD1_tandem_CHD3-4_like	465..544	CDD:349314
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	549..571
		CD2_tandem_CHD3-4_like	589..642	CDD:349309
		PLN03142	698..>1214	CDD:215601	141/652 (22%)
		DEAH box	847..850		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1209..1253
		DUF1087	1298..1351	CDD:461922
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1351..1411
		CHDII_SANT-like	1389..1529	CDD:461920
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1524..1564
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1597..1640
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1658..1696
		CHDCT2	1733..1878	CDD:462358