Protein Alignment CG10445 and RAD54B

DIOPT Version :10

• Sequence 1: NP_649751.2
• Gene: CG10445 / 40938
• FlyBaseID: FBgn0037531
• Length: 945
• Species: Drosophila melanogaster
• Sequence 2: NP_036547.1
• Gene: RAD54B / 25788
• HGNCID: 17228
• Length: 910
• Species: Homo sapiens
• Alignment Length: 1029
• Identity: 202/1029 - (19%)
• Similarity: 353/1029 - (34%)
• Gaps: 376/1029 - (36%)

  Fly    17 CSIQDQSSVPVPDSSGEINNWMEPEPVDSLELSGEYADNESAIF--------------VSASEYN 67
            ||:    ::|..:|:.||||        ....||:|......:.              |:.|:..
Human    63 CSL----NLPSEESTREINN--------RDNCSGKYCFEAPTLATLDPPHTVHSAPKEVAVSKEQ 115

  Fly    68 EKKAQIDQLVQ--KILTMEQQQRQLEENASETKELCDLKLHLEKLNARLEALG-----EFLDTLR 125
            |:|:  |.||:  .::..:..:::.::...:...:...|..:.| |...:.:|     :|.:..:
Human   116 EEKS--DSLVKYFSVVWCKPSKKKHKKWEGDAVLIVKGKSFILK-NLEGKDIGRGIGYKFKELEK 177

  Fly   126 LREDQ------QEIKI------ED-----------NSELVDHTEQPK---WSNLYSGLNRYRQKA 164
            :.|.|      :||::      :|           .|..:.|:.|..   :||.:..:.:...|.
Human   178 IEEGQTLMICGKEIEVMGVISPDDFSSGRCFQLGGGSTAISHSSQVARKCFSNPFKSVCKPSSKE 242

  Fly   165 NHTAAQFYQHKSNIIDSLKTLYEP------IQPRP-------------AIDDLEKQPALLLVRLL 210
            |         :.|...:.|..::|      :.|||             .:.|:...| .|:..|.
Human   243 N---------RQNDFQNCKPRHDPYTPNSLVMPRPDKNHQWVFNKNCFPLVDVVIDP-YLVYHLR 297

  Fly   211 KHQQ-------SCLKWMQFRERQKISGGILADDMGLGKTLSMIALILASEETKNRKREEKKKALT 268
            .||:       .|:..|:...|   .|.||||:|||||||..|:||
Human   298 PHQKEGIIFLYECVMGMRMNGR---CGAILADEMGLGKTLQCISLI------------------- 340

  Fly   269 LKWTQEFNRVYCKEIRKISMFDDEEESGKEEEQYEPPEKRTCHVKTKKINQFRILDDDDNDAGDK 333
              ||.:....|                                                   |.|
Human   341 --WTLQCQGPY---------------------------------------------------GGK 352

  Fly   334 AVVEDEQKDLLAKTPEPEVFSSDEEEEHLSNGRYPSANTLVVCPMSVMCQWAHEVASKVAQNAIR 398
            .|::                                 .||:|.|.|::..|..|....:....|:
Human   353 PVIK---------------------------------KTLIVTPGSLVNNWKKEFQKWLGSERIK 384

  Fly   399 VLTFHGPNRHEIGIEAFRSYDLVITSYNLVVNELKRYGNTSPLFAVYWNRVILDEAHIIRNSKTN 463
            :.|....::.|..|::. .|.::|.||.:::..|.:..|      :.::.:|.||.|.::||...
Human   385 IFTVDQDHKVEEFIKSI-FYSVLIISYEMLLRSLDQIKN------IKFDLLICDEGHRLKNSAIK 442

  Fly   464 CCNSVCQLRAHCHWALTGTPVQNRGVDVFALLRFVNVPNFQDLQQWKK--------------NLN 514
            ...::..|.......|||||:||...:.|||:.|||......|..::|              :..
Human   443 TTTALISLSCEKRIILTGTPIQNDLQEFFALIDFVNPGILGSLSSYRKIYEEPIILSREPSASEE 507

  Fly   515 ESMLGHRR---LNFIIKPLMLRRTKQKLQASGDMPALPSLKIELICVQLSKTEMAVYQILSAISK 576
            |..||.||   |..:....:||||::.:.     ..||           .|.|..|:....|:..
Human   508 EKELGERRAAELTCLTGLFILRRTQEIIN-----KYLP-----------PKIENVVFCRPGALQI 556

  Fly   577 KIFTQFLLQREKGNSDLNYYS----LERTPQFIAGHMSDERYNEIYERFLKSLGYNPGEKILGIY 637
            :::.:.|      ||.:..:.    ||.:|.
Human   557 ELYRKLL------NSQVVRFCLQGLLENSPH---------------------------------- 581

  Fly   638 ILVLLLRLRQFCCHPGLMIGMLRGALTAEDVQNVKVDASDVEGQLKMDVLAELDKFDETDSEDDC 702
             |:.:..|::.|.||.|:...::                                      |.:|
Human   582 -LICIGALKKLCNHPCLLFNSIK--------------------------------------EKEC 607

  Fly   703 CDEEDSTRRDGNFK--LEVIKDEIKEENVPWDSGDDLPTASSFEDQLDSARALKLLNPQNPIFQF 765
            ....|.......:|  |.|.         |.|                          .||:...
Human   608 SSTCDKNEEKSLYKGLLSVF---------PAD--------------------------YNPLLFT 637

  Fly   766 IRPSAKLKMVIDKLEELL--TGTNDKIIVTSQWVSYLAIVRKRLQDLSWETLDFNGQLTAKEREI 828
            .:.|.||: |:.||..::  ....:|:::.|.:...|.|:::..:...:.....:||....:|:.
Human   638 EKESGKLQ-VLSKLLAVIHELRPTEKVVLVSNYTQTLNILQEVCKRHGYAYTRLDGQTPISQRQQ 701

  Fly   829 VLRDFNANNEK-RVLLLSLTAGGVGLNLNVANHMLIVDLHWNPQLERQAQDRIYRYGQTKPTFIY 892
            ::..||:.:.. .:.|||..||||||||...:|:::.|:.|||..:.||..|::|.||..|..||
Human   702 IVDGFNSQHSSFFIFLLSSKAGGVGLNLIGGSHLILYDIDWNPATDIQAMSRVWRDGQKYPVHIY 766

  Fly   893 RYMCQDTVEQRIKSLQDCKLEIAKVVLPEEGGEVTKCVGG-GLNLAELKKLFEM 945
            |.:...|:|::|...|..|..:...|:     ::||.... ..::.|||.||.:
Human   767 RLLTTGTIEEKIYQRQISKQGLCGAVV-----DLTKTSEHIQFSVEELKNLFTL 815

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10445	NP_649751.2	HepA	<113..919	CDD:440319	173/888 (19%)
		DEAD-like_helicase_N	209..534	CDD:475120	73/348 (21%)
RAD54B	NP_036547.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..33
		HepA	<296..794	CDD:440319	151/748 (20%)
		DEXHc_RAD54B	296..530	CDD:350824	73/348 (21%)
		DEGH box	431..434		2/2 (100%)