Protein Alignment CG10445 and ERCC6

DIOPT Version :10

• Sequence 1: NP_649751.2
• Gene: CG10445 / 40938
• FlyBaseID: FBgn0037531
• Length: 945
• Species: Drosophila melanogaster
• Sequence 2: NP_000115.1
• Gene: ERCC6 / 2074
• HGNCID: 3438
• Length: 1493
• Species: Homo sapiens
• Alignment Length: 983
• Identity: 188/983 - (19%)
• Similarity: 314/983 - (31%)
• Gaps: 405/983 - (41%)

  Fly    15 QSCSIQDQSSVPVP----------------DSSGEINNWM---EPEPVDSLELSGEYADNESAIF 60
            |..::|.|..|.:|                ||.||.:.:.   |.|..:..|:.|..||    :.
Human   336 QKRALQFQGKVGLPKARRPWESDMRPEAEGDSEGEESEYFPTEEEEEEEDDEVEGAEAD----LS 396

  Fly    61 VSASEYNEKKAQIDQLVQKILTMEQQQRQLEENASETKELCDL---------------------- 103
            ...::|..|........||.:.:::.......::.|..|...:
Human   397 GDGTDYELKPLPKGGKRQKKVPVQEIDDDFFPSSGEEAEAASVGEGGGGGRKVGRYRDDGDEDYY 461

  Fly   104 KLHLEKLNARLEALGEFLDTLRLREDQQEIKIEDNSELVDHTEQPKWSNLYSGLNRYRQKANHTA 168
            |..|.:.|           .|||::.::.:|:||:||..|
Human   462 KQRLRRWN-----------KLRLQDKEKRLKLEDDSEESD------------------------- 490

  Fly   169 AQFYQHKSNIIDSLKTLYEPIQPRPAIDDLEKQPALLLVRLLKHQQSCLKWMQFRERQKISGGIL 233
            |:|                        |:..|.|..|..:|.|:||:.::|:.....|: :||||
Human   491 AEF------------------------DEGFKVPGFLFKKLFKYQQTGVRWLWELHCQQ-AGGIL 530

  Fly   234 ADDMGLGKTLSMIALILASEETKNRKREEKKKALTLKWTQEFNRVYCKEIRKISMFDDEEESGKE 298
            .|:||||||:.:||.:.....:|.|.|.
Human   531 GDEMGLGKTIQIIAFLAGLSYSKIRTRG------------------------------------- 558

  Fly   299 EEQYEPPEKRTCHVKTKKINQFRILDDDDNDAGDKAVVEDEQKDLLAKTPEPEVFSSDEEEEHLS 363
                                                                            |
Human   559 ----------------------------------------------------------------S 559

  Fly   364 NGRYPSAN-TLVVCPMSVMCQWAHEVASKVAQNAIRVLTFHGPNRHEIGI----------EAFRS 417
            |.|:.... |::|||.:||.||..|..:......:.:|       ||.|.          :....
Human   560 NYRFEGLGPTVIVCPTTVMHQWVKEFHTWWPPFRVAIL-------HETGSYTHKKEKLIRDVAHC 617

  Fly   418 YDLVITSYN---LVVNELKRYGNTSPLFAVYWNRVILDEAHIIRNSKTNCCNSVCQLRAHCHWAL 479
            :.::||||:   |:.:::.||.         |:.|||||.|.|||.......:..|.|......|
Human   618 HGILITSYSYIRLMQDDISRYD---------WHYVILDEGHKIRNPNAAVTLACKQFRTPHRIIL 673

  Fly   480 TGTPVQNRGVDVFALLRFV------NVPNFQDLQQWKKNLNESMLGHRR---------------L 523
            :|:|:||...::::|..|:      .:|.|  ::|:...:  :|.|:..               |
Human   674 SGSPMQNNLRELWSLFDFIFPGKLGTLPVF--MEQFSVPI--TMGGYSNASPVQVKTAYKCACVL 734

  Fly   524 NFIIKPLMLRRTKQKLQASGDMPALPSLKIELICVQLSKTEMAVYQILSAISKKIFTQFLLQREK 588
            ...|.|.:|||.|..::.|..:|              .|.|..::..|:....|::..|:..:|.
Human   735 RDTINPYLLRRMKSDVKMSLSLP--------------DKNEQVLFCRLTDEQHKVYQNFVDSKEV 785

  Fly   589 GNSDLNYYSLERTPQFIAGHMSDERYNEIYERFLKSLGYNPGEKILGIYILVLLLRLRQFCCHPG 653
                  |..|....|..:|                                  |:.||:.|.||.
Human   786 ------YRILNGEMQIFSG----------------------------------LIALRKICNHPD 810

  Fly   654 LMIGMLRGALTAEDVQNVKVDASDVEGQLKMDVLAELDKFDETDSEDDCCDEEDSTRRDGNFKLE 718
            |..|         ..:|:|
Human   811 LFSG---------GPKNLK---------------------------------------------- 820

  Fly   719 VIKDEIKEENVPWDSGDDLPTASSFEDQLDSARALKLLNPQNPIFQFIRPSAKLKMVIDKLEELL 783
                             .||.....|||                |.:.:.|.|: :|::.|.::.
Human   821 -----------------GLPDDELEEDQ----------------FGYWKRSGKM-IVVESLLKIW 851

  Fly   784 TGTNDKIIVTSQWVSYLAIVRKRLQDLSWETLDFNGQLTAKEREIVLRDFNANNEKRVLLLSLTA 848
            .....::::.||....|.|:...|:...:..|..:|..|...|:.::..:|.:....|.||:...
Human   852 HKQGQRVLLFSQSRQMLDILEVFLRAQKYTYLKMDGTTTIASRQPLITRYNEDTSIFVFLLTTRV 916

  Fly   849 GGVGLNLNVANHMLIVDLHWNPQLERQAQDRIYRYGQTKPTFIYRYMCQDTVEQRIKSLQDCKLE 913
            ||:|:||..||.::|.|..|||..:.||::|.:|.||.|...:||.:...|:|::|...|..|..
Human   917 GGLGVNLTGANRVVIYDPDWNPSTDTQARERAWRIGQKKQVTVYRLLTAGTIEEKIYHRQIFKQF 981

  Fly   914 IAKVVLPE 921
            :...||.:
Human   982 LTNRVLKD 989

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10445	NP_649751.2	HepA	<113..919	CDD:440319	162/840 (19%)
		DEAD-like_helicase_N	209..534	CDD:475120	73/359 (20%)
ERCC6	NP_000115.1	N-terminal domain, essential for its chromatin remodeling activity. /evidence=ECO:0000269|PubMed:29203878	1..510		40/237 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..39
		cc_ERCC-6_N	83..159	CDD:411064
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	287..323
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	344..453		18/112 (16%)
		HepA	391..987	CDD:440319	173/924 (19%)
		DEAH box. /evidence=ECO:0000255|PROSITE-ProRule:PRU00541	646..649		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1042..1147
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1181..1247
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1318..1384
		CSA-interacting motif (CIM). /evidence=ECO:0000269|PubMed:32355176	1386..1398
		Ubiquitin-binding domain (UBD). /evidence=ECO:0000269|PubMed:20541997	1400..1428
		CSB_WHD	1420..1492	CDD:439329
		Winged-helix domain (WHD). /evidence=ECO:0000305|PubMed:29203878	1429..1493
		Essential for its interaction with RNA polymerase II, transcription-coupled nucleotide excision repair activity, association with chromatin after UV irradiation and for mediating the UV-induced translocation of ERRC8 to the nuclear matrix. /evidence=ECO:0000269|PubMed:26620705	1446..1493