DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10445 and Hltf

DIOPT Version :9

Sequence 1:	NP_001246974.1	Gene:	CG10445 / 40938	FlyBaseID:	FBgn0037531	Length:	945	Species:	Drosophila melanogaster
Sequence 2:	NP_001342026.1	Gene:	Hltf / 20585	MGIID:	1196437	Length:	1003	Species:	Mus musculus

Alignment Length:	1035	Identity:	257/1035 - (24%)
Similarity:	421/1035 - (40%)	Gaps:	270/1035 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 HKQSCSIQDQSSVPVPDSSGEINNWMEPEPVDSLELSGEYADNESAIFVSASEY--NEKKAQIDQ 75
            :.:..::|.:.:.|...::.::||           ::|....:......:|..|  :.|.||::.
Mouse    79 NNEMVALQREPNNPYDKNAIKVNN-----------VNGNQVGHIKREIAAAVAYIMDNKLAQVEG 132

  Fly    76 LV----QKILTMEQQQR--QLEENASETKELCDLKLHLEKLNARLEALGEFLDTLRLREDQQEIK 134
            :|    ....||.....  ..|||.:...|  .||.|..||....:.||..|:.
Mouse   133 VVPFGASNTFTMPLYMTFWGKEENRNVVLE--QLKKHGFKLGPTPKTLGSSLEN----------- 184

  Fly   135 IEDNSELVDHTEQPKWSNLYSGLNRYRQKANHTAAQFYQHKSNIIDSLKTLYEPIQPRPAIDD-- 197
                          .|.:..:|.: |.:.| |.|.|.      ..|.|||.::.:......||
Mouse   185 --------------AWGSGRAGPS-YSRPA-HVAVQM------TTDQLKTEFDKLFEDLKEDDRT 227

  Fly   198 LEKQPA-LLLVRLLKHQQSCLKWMQFRERQK----------------------------ISGGIL 233
            :|.:|| .:...||.||:..|.||..||..|                            :.||||
Mouse   228 VEMEPAEAIETPLLPHQKQALAWMIARENSKELPPFWEQRNDLYYNTITNFSVKERPENVHGGIL 292

  Fly   234 ADDMGLGKTLSMIALILAS----------------------EETKNR------KREE-------- 262
            ||||||||||:.||:||.:                      :||..|      |:|:
Mouse   293 ADDMGLGKTLTAIAVILTNFDDGRPLLSKRGKKNHPGKEYKDETIKRRGSNMDKKEDGHSESSTC 357

  Fly   263 ----------KKKALTLKWTQEFNRVYCKEIRKISMFDDEEESGKEEEQYEPPEKRTCHVKTKKI 317
                      :|.:.||   .:.:.| |.:.||||:...|....:|.|..|.|:|....:|..::
Mouse   358 GEEPSISGTPEKSSCTL---SQLSSV-CPKRRKISVQYIESSDSEEIETSELPQKMKGKLKNVQL 418

  Fly   318 N-QFRILDDDDNDAGDKAVVEDE-----------QKDLLAKTPEPEVFSSDEEEEHLSNGRYPSA 370
            | :.|:       .|...|.||.           |:.:|.|.     .|..|..|....|....|
Mouse   419 NTKSRV-------KGSSKVKEDSKFALTFFASATQRKMLKKG-----MSMMECSEACDTGERTRA 471

  Fly   371 NTLVVCPMSVMCQWAHEVASKVAQNA-IRVLTFHGPNRHEIGIEAFRS-YDLVITSYNLVVNELK 433
             ||::||:||:..|..:....|.... :....::||:|  |...|:.| .|:::|:||::.::
Mouse   472 -TLIICPLSVLSNWIDQFGQHVKSEVHLNFYVYYGPDR--IRDSAWLSKQDIILTTYNILTHD-- 531

  Fly   434 RYG--NTSPLFAVYWNRVILDEAHIIRNSKTNCCNSVCQLRAHCHWALTGTPVQNRGVDVFALLR 496
             ||  :.|||.::.|.||||||.|.|||.......:|.:|.|...|.|||||:||...|:::||.
Mouse   532 -YGTKDDSPLHSIKWLRVILDEGHAIRNPNAQQTKAVLELEAERRWVLTGTPIQNSLKDLWSLLS 595

  Fly   497 FVNVPNFQDLQQWKKNLNESML-----GHRRLNFIIKPLMLRRTKQKLQASGDMPALPSLKIELI 556
            |:.:..|.|.:.|.:.:...:.     |.|||..:||.:.|||||........:..||..|:.:.
Mouse   596 FLKLKPFIDREWWYRIIQRPVTTGDEGGLRRLQSLIKNITLRRTKTSKIKGKPVLELPERKVFIQ 660

  Fly   557 CVQLSKTEMAVYQILSAISKKIFTQFLLQREKGNSDLNYYSLERTPQFIAGHMSDERYNEIYERF 621
            .:.||:.|..:||.:              :.:|.:.:..|..|.|   :..|.:|
Mouse   661 HITLSEEERKIYQSV--------------KNEGKAAIGRYFTEGT---VLAHYAD---------- 698

  Fly   622 LKSLGYNPGEKILGIYILVLLLRLRQFCCHPGLMIGMLRGALTAEDVQNVKVDASDVEGQLKMDV 686
                            :|.|||||||.|||..|:         ...:.:.....||...:|:..:
Mouse   699 ----------------VLGLLLRLRQICCHTHLL---------TNGMSSSGPSRSDTPEELRKML 738

  Fly   687 LAELDKFDETDSEDDCCDEEDST----------------------RRDGNFKLEVIKDEIKEENV 729
            :.::.....:.|:::|....||.                      ....:.|..:.::||..:|:
Mouse   739 IEKMKIILSSGSDEECAICLDSLTFPVITHCAHVFCKPCICQVIHSEQPHAKCPLCRNEIHGDNL 803

  Fly   730 PWDSGDDLPTASSFEDQLDSARALKLLNPQNPIFQFIRPSAKLKMVIDKLEELLT-GTNDKIIVT 793
            .....::|...|..|..::                 .:.|:|:..::..|.||.| ..|.|.:|.
Mouse   804 LECPPEELACDSDKESSME-----------------WKSSSKINALMHALIELRTKDPNIKSLVV 851

  Fly   794 SQWVSYLAIVRKRLQDLSWETLDFNGQLTAKEREIVLRDFNANNE---KRVLLLSLTAGGVGLNL 855
            ||:.::|:::...|:...:.....:|.:..|:|...::.|. |.|   ..::||||.||||||||
Mouse   852 SQFTTFLSLIETPLKASGFVFTRLDGSMAQKKRVESIQRFQ-NTEAGSPTIMLLSLKAGGVGLNL 915

  Fly   856 NVANHMLIVDLHWNPQLERQAQDRIYRYGQTKPTFIYRYMCQDTVEQRIKSLQDCKLEIA 915
            ..|:.:.::|..|||..|.|..||.:|.||.:...|.:::.:|:||:.:..:|:.|.::|
Mouse   916 CAASRVFLMDPAWNPAAEDQCFDRCHRLGQKQEVIITKFIVKDSVEENMLKIQNTKRDLA 975

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10445	NP_001246974.1	HepA	<90..945	CDD:223627	244/950 (26%)
CG10445	NP_001246974.1	DEAD-like_helicase_N	209..534	CDD:421690	122/419 (29%)
Hltf	NP_001342026.1	DNA binding. /evidence=ECO:0000250	38..287		51/253 (20%)
		HIRAN	60..153	CDD:312360	13/84 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	317..373		6/55 (11%)
		HepA	<472..1003	CDD:223627	153/579 (26%)
		DEGH box	551..554		2/2 (100%)
		RING-HC_HLTF	752..795	CDD:319423	4/42 (10%)
		RING-HC finger (C3HC4-type)	754..794	CDD:319423	4/39 (10%)
		Interaction with SP1 and SP3. /evidence=ECO:0000250	919..1003		18/57 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3486
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000507
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101296
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2250
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.790