Protein Alignment CG10445 and F53H4.6

DIOPT Version :10

• Sequence 1: NP_649751.2
• Gene: CG10445 / 40938
• FlyBaseID: FBgn0037531
• Length: 945
• Species: Drosophila melanogaster
• Sequence 2: NP_001359661.1
• Gene: F53H4.6 / 181672
• WormBaseID: WBGene00010011
• Length: 922
• Species: Caenorhabditis elegans
• Alignment Length: 865
• Identity: 147/865 - (16%)
• Similarity: 256/865 - (29%)
• Gaps: 371/865 - (42%)

  Fly   210 LKHQQSCLKWMQFRERQKISGGILADDMGLGKTLSMIALILASEETKNRKREEKKK-ALTLKWTQ 273
            ||::|:...||:...:..||    |.:....:         |:...:|.:|.:|.. |:.:|.|.
 Worm    42 LKYRQAKAFWMRHTGQLNIS----ARNANKNR---------ANASERNEQRPDKNNDAIVIKPTN 93

  Fly   274 EFNRVYCKEIRKISMFDDEEESGKEEEQYEPP-EKRTCHVKT---------------KKINQFRI 322
            ..|             |.:....:.:...:|| |||  |.:|               :|.|.|..
 Worm    94 TSN-------------DRKSLKRRPDALPDPPIEKR--HKQTTVDSDDDVMIIERTPEKTNSFET 143

  Fly   323 LD--DDDNDAGDKAVVEDEQKDLLAKTPEPE------VFSSDEEE------EHLS---------- 363
            .|  ||||.:.|...     ::.....||..      |.|.|.:|      |||:
 Worm   144 PDSIDDDNMSDDMRC-----RNTFPYIPESRTTVTRMVRSEDGKESRKPCNEHLTTKWLQTQMDH 203

  Fly   364 -------------------------NGRYPS----------ANTLVVCPMSVMCQW--------- 384
                                     :..:.|          ::.|:|||.:.:.:|
 Worm   204 NRGGIVIDENVLNKPRKAWQGASFLSSIFESFRKFKNSAGLSSALIVCPEAKLSEWMLAIRHQFD 268

  Fly   385 -------------AHEV------------ASKVAQNAIRVLTFHGPNRHEIGIEAFRSYDLVITS 424
                         .||.            ..|:...|:.:.||....:||..|...:
 Worm   269 YARIFVLHKASTTGHETDYVEKIFQDLKETKKIPFGAVLLTTFAEFGKHEKAIVDHQ-------- 325

  Fly   425 YNLVVNELKRYGNTSPLFAVYWNRVILDEA--HIIRNSKTNCCNSVCQLRAHCHWALTGTPVQNR 487
                                 |..|.||:.  .:.|..: |....:.:|:....:..|.|.|::|
 Worm   326 ---------------------WQLVYLDQGLFEMTRQMR-NQIEGMKKLKTPNRFIFTDTSVRDR 368

  Fly   488 GVDVFALLRFVNVPNFQDLQQWKKNL-NESMLGHR----------------RLNFIIKPLMLRRT 535
            ..:::..:.||......|.:.::.|. |...:|.|                .|:..:|||:|.|.
 Worm   369 LEELWWNVDFVFPGRLSDYKTFQTNFQNVIEIGCRLDATPEEASTAYECIVALHVALKPLILSRL 433

  Fly   536 KQKLQASGDMPALPSLKIELIC-VQLSKTEMA-VYQILSAISKKIFTQFLLQREKGNSDLNYYSL 598
            .:.          |:   :..| .::||.|:. :..|:..:||:       ||
 Worm   434 IKN----------PN---DWFCRREISKKEVEHIKDIICPLSKR-------QR------------ 466

  Fly   599 ERTPQFIAGHMSDERYNEIYERFLKSLGYNPGEKILGIY-----ILVLLLRLRQFCCHPGLMIGM 658
                          |..:||:|         .:::.||.     ..|.|.:|...|.|||:..|
 Worm   467 --------------RCLKIYKR---------SDEVQGILRQSSAACVGLKKLTDICDHPGIHKG- 507

  Fly   659 LRGALTAEDVQNVKVDASDVEGQLKMDVLAELDKFDETDSEDDCCDEEDSTRRDGNFKLEVIKDE 723
                                       |..|..||
 Worm   508 ---------------------------VTPETKKF------------------------------ 515

  Fly   724 IKEENVPWDSGDDLPTASSFEDQLDSARALKLLNPQNPIFQFIRPSAKLKMVIDKLEELLTGTND 788
                             .|.||                       |.|:::|...|:..|.....
 Worm   516 -----------------GSIED-----------------------SGKVRIVFQLLDMWLGTPGA 540

  Fly   789 KIIVTSQWVSYLAIVRKRLQDLSWETLDFNGQLTAKEREIVLRDFNANNEKRVLLLSLTAGGVGL 853
            |:::.:|......::...::........|.....|.:||.|:..|....:.::||.......:|:
 Worm   541 KVVIFTQRRQVAVMLEHFMKQKRIAYCSFLKAKNAYDRENVVNYFENTTDVQILLAPSIMFKLGM 605

  Fly   854 NLNVANHMLIVDLHWNPQ-----------LERQAQD----RIYRYGQTKPTFIYRYMCQDTVEQR 903
            .|..||.::|.|..|||.           |.::.:|    |:...|..:.:..::.:.:..:..|
 Worm   606 QLKKANKVIIFDPEWNPDSDVKHTREMSFLTKKVEDVTVVRLVSEGTVEDSSYFKKLWESGLASR 670

  Fly   904 IKSLQDCKLE--IAKVVLPE 921
            :  |.|.|.|  :.:..|.|
 Worm   671 L--LSDPKFEPFVPRTTLEE 688

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10445	NP_649751.2	HepA	<113..919	CDD:440319	145/861 (17%)
		DEAD-like_helicase_N	209..534	CDD:475120	80/452 (18%)
F53H4.6	NP_001359661.1	DEAD-like_helicase_N	195..381	CDD:475120	28/215 (13%)
		HepA	<247..655	CDD:440319	97/590 (16%)