Protein Alignment CG10445 and F54E12.2

DIOPT Version :10

• Sequence 1: NP_649751.2
• Gene: CG10445 / 40938
• FlyBaseID: FBgn0037531
• Length: 945
• Species: Drosophila melanogaster
• Sequence 2: NP_502137.1
• Gene: F54E12.2 / 178054
• WormBaseID: WBGene00010061
• Length: 1091
• Species: Caenorhabditis elegans
• Alignment Length: 1024
• Identity: 268/1024 - (26%)
• Similarity: 428/1024 - (41%)
• Gaps: 282/1024 - (27%)

  Fly     9 TTEIHKQSCSIQ-DQSSV----PVPDSSGEINNWMEPEP----VDSLELSGEYADNESAIFVSAS 64
            :.|..|...:|. |.|.:    ||..:|..     .|||    :.:..::.|||.      :|..
 Worm   256 SNEKRKSGIAINLDDSDIIDVTPVKTTSSR-----PPEPQRPRLPTSPINSEYAK------LSYK 309

  Fly    65 EYNEKKAQIDQLVQKILTME-------QQQRQLEENASETKELCDLKLHLEKLNARLEALGEFLD 122
            |...||.::..|:...|.:.       :|.::|::.....||:               .|.|  :
 Worm   310 ELLAKKNKVMGLISLSLDLPDGGRRVIKQFQELDDEVERRKEM---------------GLAE--E 357

  Fly   123 TLRLREDQQEIKIEDNS-------------------------ELVD--HTEQPKWSNLYSGLNRY 160
            .:...||.:...|||:.                         .:||  ...||.::.:....|:.
 Worm   358 IVDDDEDDEIFVIEDDEPSHRQVAPKFPSGSVMTQNGLLPKRHIVDPLKAPQPDFNAMLEKDNKK 422

  Fly   161 RQKANHTAAQFYQHKSNIIDS-LKTLYEPIQPRPAIDDLEKQPALLLVRLLKHQQSCLKWMQFRE 224
            ......|..: |:....:.|. ::.|.|.....|...:|...|....:.|:.||::.|.||::||
 Worm   423 MMSGKMTDEK-YKRIQLVSDRVVRQLAEATHTIPDETELTDTPKGFKLELMPHQKAGLTWMRWRE 486

  Fly   225 RQKISGGILADDMGLGKTLSMIALILASEETKNRKREEKKKALTLKWTQEFNRVYCKEIRKISMF 289
            .|...|||||||||||||||||:||...:..:..:||:
 Worm   487 TQPQPGGILADDMGLGKTLSMISLIAHQKAARRARRED--------------------------- 524

  Fly   290 DDEEESGKEEEQYEPPEKRTCHVKTKKINQFRILDDDDNDAGDKAVVEDEQKDLLAKTPEPEVFS 354
                                              .:||.|...:.||:::
 Worm   525 ----------------------------------GNDDKDKEKRKVVKEQ--------------- 540

  Fly   355 SDEEEEHLSNGRYPSANTLVVCPMSVMCQWAHEVASKVAQNAIRVLTFHGPNR-HEIGIEAFRSY 418
                      |..||..||:|.|.|::.||..|:..::..:.:....|||..: .:|.......|
 Worm   541 ----------GLIPSNGTLIVAPASLIHQWDAEIDRRLDDSVLSTYMFHGTKKQRDIDARRLARY 595

  Fly   419 DLVITSYNLVVNEL--------------------------KRYG-NTSPLFAVYWNRVILDEAHI 456
            |:|||::||:.|||                          :..| :.|.|..:.|:||||||||.
 Worm   596 DVVITTFNLIANELIEKIRTKSKADDSSDGESDSNHTGIRRAVGKDDSVLAQICWSRVILDEAHT 660

  Fly   457 IRNSKTNCCNSVCQLRAHCHWALTGTPVQNRGVDVFALLRFVNVPNFQDLQQWKKNLNESMLGHR 521
            |:|.::....:||:|.|...|.|:|||:.|...|:::|:||:.:..|.|.:.||    ||::..:
 Worm   661 IKNRQSLASKAVCRLSAFSRWCLSGTPIHNNLWDLYSLVRFLRIRPFSDDKYWK----ESIMPMK 721

  Fly   522 -----RLNFIIKPLMLRRTKQKLQA--SGDMPALPSLKIELICVQLSKTEMAVYQILSAISKKIF 579
                 |:|.:.|.|:|||||.:..|  :..:..||...:|:..::|...|...|:|:...:|| |
 Worm   722 PIMADRVNLLTKNLLLRRTKDQTCAVTNQKLVQLPPKNVEVHELELDGDEAQAYEIMMEAAKK-F 785

  Fly   580 TQFLLQREKGNSDLNYYSLERTPQFIAGHMSDERYNEIYERFLKSLGYNPGEKILG------IYI 638
            .:.|||   .::|:..:.........||     :..|:...|    .:.|.:...|      ..:
 Worm   786 VKKLLQ---DSNDMKNHGFIPRRNRRAG-----KEGEVQNPF----NFGPRDLAAGSNFEKMSCV 838

  Fly   639 LVLLLRLRQFCCHPGLMIGMLRGALTAEDVQNVKVDASDVEGQLKMDVLAELDKFDETDSEDDCC 703
            |:|||||||.|.|..:       ..|..|:....:...|...:..:|.|.||
 Worm   839 LMLLLRLRQACVHFNI-------TKTGVDMDAFSLIGGDNAEEANVDDLNEL------------- 883

  Fly   704 DEEDSTRRDGNFKLEVIKDEIKEENVPWDSGDDLPTASSFEDQLDSARA-LKLLNPQNPIFQFIR 767
                         ||      |..|:...:||:        ::.|..|| .::.:|     .::
 Worm   884 -------------LE------KTMNMTLGNGDN--------EERDKPRATTRIFDP-----DYL- 915

  Fly   768 PSAKLKMVIDKLEELLTGTNDKIIVTSQWVSYLAIVRKRLQDLSWETLDFNGQLTAKEREIVLRD 832
             |.|:|..::.:|.::. ..:|:::.|||.|.|.::...::...::.....||:..|:|:..:..
 Worm   916 -SCKIKNTLEIVENIME-KKEKVVIVSQWTSVLNLIEIHIKSSGFKYTSITGQVLVKDRQERVDS 978

  Fly   833 FNANNEK---RVLLLSLTAGGVGLNLNVANHMLIVDLHWNPQLERQAQDRIYRYGQTKPTFIYRY 894
            |  |.||   ||:||||.||||||||...||:::|||||||.||:||.|||||.||.|..||:|.
 Worm   979 F--NREKGGARVMLLSLAAGGVGLNLTGGNHLVMVDLHWNPALEQQAFDRIYRMGQKKDVFIHRL 1041

  Fly   895 MCQDTVEQRIKSLQDCKLEIAKVVLPEEGGEVTKCVGGGLNLAELKKLF 943
            :.:.|:|||:..||..|:.:|..||   .|..|:.: ..|..|::|.||
 Worm  1042 VTKGTIEQRVVMLQKDKVALASSVL---DGNATRKM-NKLTTADIKMLF 1086

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10445	NP_649751.2	HepA	<113..919	CDD:440319	235/878 (27%)
		DEAD-like_helicase_N	209..534	CDD:475120	99/357 (28%)
F54E12.2	NP_502137.1	HepA	<458..1067	CDD:440319	219/771 (28%)