Protein Alignment CG10445 and T05A12.4

DIOPT Version :10

• Sequence 1: NP_649751.2
• Gene: CG10445 / 40938
• FlyBaseID: FBgn0037531
• Length: 945
• Species: Drosophila melanogaster
• Sequence 2: NP_001023359.1
• Gene: T05A12.4 / 177453
• WormBaseID: WBGene00020235
• Length: 1622
• Species: Caenorhabditis elegans
• Alignment Length: 992
• Identity: 201/992 - (20%)
• Similarity: 372/992 - (37%)
• Gaps: 297/992 - (29%)

  Fly    75 QLVQKILTMEQQQRQLEENASETKELC--------DLKL-HLEKLNARLEALGEFLDTLR----- 125
            ||:..::.:.:..:.|.:.....:.:|        |..: |.:..|:.::.:.:..:|::
 Worm    96 QLIWILMKLSKTPKILVQAGISLQYICLPTNQIRIDFYIDHAKINNSLIDFIPKLTETMKHKYHI 160

  Fly   126 -----LREDQQEIKIEDNSE-LVDHTEQPK-----WSNLYSGLNRYRQKANHTAAQFYQHKSNI- 178
                 ::.|::|...:.|.: .||:.||.:     :...::.:|.|:.|.:|....|..::|::
 Worm   161 LLRDIIKGDEKETPFDPNDDNEVDNCEQRRQEDMNFEQFFTYINVYKDKHDHQIPNFKLNESDLN 225

  Fly   179 -------IDSLK-TLYEPI--QPRPAIDDLEKQPALLLVRLLKHQQS----CLKWMQFRERQKI- 228
                   .|::: .||..:  :|...|:.:.|...|.....|.:..|    .|..|...||:.|
 Worm   226 CDLMQYQKDTVRWMLYRELNHEPDGNIEWMIKSEKLASDTSLVYYPSIGAIALNEMTIEERKDIE 290

  Fly   229 -----SGGILADDMGLGKTLSMIALILASEETKNRKREEKKKALTLKWTQEFNRVYCKEIRKISM 288
                 .||||||:||||||:..::||     ..|||..                       |:.:
 Worm   291 KRFTLKGGILADEMGLGKTIQALSLI-----ATNRKHS-----------------------KVEI 327

  Fly   289 FDDEEESGKEE---------------EQYEPPEKRTCHVKTKKINQFRILDDDDNDAGDKAVVED 338
            :|   |||:.|               :|.:..|.....:|..:.||..|..:.::....:.::..
 Worm   328 YD---ESGEVETVNRDESKSTNSSIAQQIKLAESSYAEMKGARQNQADIRYNLNSFCDGETILCS 389

  Fly   339 EQKDLLA-----------KTPEPEVFSSDEEEEHLSNGRYPSANTLVVCPMSVMCQWAHEVASKV 392
            ....:.:           |..:.:......|.|:    |.....||::.|.|::.||..|::...
 Worm   390 NCSQMCSAKICGWDFDKFKNEKFQCSKCTSESEN----RRAVGTTLIILPESLIFQWFTEISKHC 450

  Fly   393 AQNAIRVLTFHGPNRH------EIGIEAFRSYDLVITSYNLVVNEL----------------KRY 435
            :.| |:|:.:.|..:|      |:.     |||:::|:|:.:.||:                |..
 Worm   451 SDN-IKVMFYFGIRKHGYLQPCEMD-----SYDVILTTYDTLRNEMSFSEEKGPPRNLRNESKTL 509

  Fly   436 GNTSPLFAVYWNRVILDEAHIIRNS-KTNCCNSVCQLRAHCHWALTGTPVQNRGVDVFALLRFVN 499
            ..||.|..|.:.|:|:||:.::.:. .:.....:.:|.|...|.:||||:......::.|..|:|
 Worm   510 NLTSSLMHVEFWRIIVDESQVLPHGVSSQLTRMLMKLHAENWWCVTGTPLVKSIAGIYPLFNFLN 574

  Fly   500 VPNFQDLQQWKKNLNESMLGHRRLNF---------------------IIKPLMLRRTKQKLQASG 543
            :..|...|.:.:.::.     :.|||                     |:..:|.|:|||......
 Worm   575 LFPFGSPQFFSQYVHP-----QYLNFALSLRDEALDKNNLPRVFLLEILSKMMSRKTKQDKSVQL 634

  Fly   544 DMPALPSLKIELICVQLSKTEMAVYQ---------------------ILSAIS--KKIFTQ---- 581
            .:|.|  .::|.| :..:..|...|:                     :||.:.  :|:..:
 Worm   635 KLPKL--TEVEKI-IYFTTVEERQYKDEKERLRNIVERAIGNADNSDLLSDLQCREKVLQELRLL 696

  Fly   582 ---FLLQREKGNSDLNYYSLERTPQFIAGHMSDERYNEIYERFLKSLGYNPGEKILGIYILVLLL 643
               .||.:.|..||  ..|....|:.:...:...:...|...|.:.|.|:.|  :.|:.||:.:
 Worm   697 RQIILLGQRKTESD--KVSCVLAPETVIFKLIKNKKTTIKANFREYLSYSLG--VAGVQILMDM- 756

  Fly   644 RLRQFCCHPGLMIGMLRGALTAED---------VQNVKVDASDVEGQLKMDVLAELDKFDETDSE 699
                    |...|.....||...|         :..:|.|:|..:.    ..|.|.|:.|:.|.|
 Worm   757 --------PQTAIETYSSALINYDELILAERNHLPEIKNDSSRDDS----PCLLEEDEDDDFDGE 809

  Fly   700 DDCCDEEDSTRRDGNFKL-----------EVIKDEIKEENVPWDSGDDLPTASSFEDQLDSARAL 753
            ||...|:   ::..| ||           ::.|..:|.:|:..|     ||:...|   .:.|.
 Worm   810 DDGSAEK---KKKPN-KLNELNGFLGGIHQISKKYMKSKNLNLD-----PTSRKSE---RNGRV- 861

  Fly   754 KLLNPQNPIFQFIRPSAKLKMVIDKLEELLTGTNDKIIVT----SQWVSYLAIVR--KRLQDLSW 812
                .:..|.:..||....:..:|..||....||::...|    :|....|..|:  |.:|.|::
 Worm   862 ----NEREIEEITRPKDAKRSRLDVEEEDEMETNEEKSNTPCSSTQDEGNLEYVKGQKHIQKLAF 922

  Fly   813 E-----TLDFNGQLTAKEREIVLRDFNANNEKRVLLLSLTAGGVGLNLNVANHMLIVDLHWNPQL 872
            .     |:|     |.:|..::|..:|         :.|:.|                   .||.
 Worm   923 AAIEPITID-----TTQEVHLILNMYN---------IQLSMG-------------------FPQA 954

  Fly   873 ERQAQDRI----YRYGQ 885
            :|.:.||:    .||.|
 Worm   955 DRVSLDRLQQIFVRYFQ 971

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10445	NP_649751.2	HepA	<113..919	CDD:440319	194/945 (21%)
		DEAD-like_helicase_N	209..534	CDD:475120	86/404 (21%)
T05A12.4	NP_001023359.1	DEXDc_SHPRH-like	296..624	CDD:350766	79/373 (21%)
		RING_Ubox	1345..1393	CDD:473075
		SF2_C_SNF	1418..1548	CDD:350180