Protein Alignment CG10445 and chd-1

DIOPT Version :10

• Sequence 1: NP_649751.2
• Gene: CG10445 / 40938
• FlyBaseID: FBgn0037531
• Length: 945
• Species: Drosophila melanogaster
• Sequence 2: NP_491994.2
• Gene: chd-1 / 172432
• WormBaseID: WBGene00010369
• Length: 1461
• Species: Caenorhabditis elegans
• Alignment Length: 1070
• Identity: 215/1070 - (20%)
• Similarity: 390/1070 - (36%)
• Gaps: 367/1070 - (34%)

  Fly     2 ESSSPSDTTEIHKQSCSIQDQSSVPVPDSSGEINNWMEPEPVDSLELSGEYADNESAIFVSASEY 66
            ||||.||.....|....::::.: |..:|:.|.|:..| :..||.|.|.:.:|:..    .|||
 Worm     6 ESSSGSDAEPDEKTDEPVREEEN-PEGNSTSEDNDEKE-KAADSPESSSDQSDDSD----DASE- 63

  Fly    67 NEKKAQIDQLVQKILTMEQQQRQLEENASETKELCDLKLHLEKLNARLEALGEFLDTLRLREDQQ 131
            |...::.|:...|  ......|.::   :||::|.:.:.:..:..               |..:|
 Worm    64 NSSSSEPDEPAPK--KKNNNNRGMD---AETRKLLENENYFRRSK---------------RSKRQ 108

  Fly   132 EIKIEDNSELVDHTEQPKWSN------------------LYSGLNRYRQKANHTAAQFYQHKSNI 178
            :....|||| ...:.:..|.:                  ..|.:.|...|.|...|:  ::..:.
 Worm   109 DDSPSDNSE-ESQSSEDDWDDRRKPRRTVTKKVVKQTKKAVSVVKRKSVKGNVNYAE--KNSDDD 170

  Fly   179 IDS---LKTLYEPIQPRPAIDDLEKQPALL---LVRLLK-------------------------- 211
            ||.   |:...||..|       .:.||:|   :.|::|
 Worm   171 IDDDDVLEWDEEPAVP-------AEGPAILTETVERVIKWRHGVPGATGSATTCYNIADKGDPND 228

  Fly   212 -------HQQSCLKWMQFRERQKISGGILADDMGLGKTLSMIALILASEETKNRKREEKKKALTL 269
                   .||..:||..:....           ...::.:.:||:.|....|.:...:|:|.:.:
 Worm   229 QIPGDKTEQQFFVKWTGWSHLH-----------NTWESENSLALMNAKGLKKVQNYVKKQKEVEM 282

  Fly   270 KWTQEFNRVYCKEIRKISMFDDEEESGKEE-EQYEPPEKRTCH-----------VKTKKINQFRI 322
             |.:..::.|      |..|:.|::..:|. |:|:..|:...|           :.|:.:.::..
 Worm   283 -WKRSADKEY------IEFFECEQQMAEELCEEYKKVERVVAHQTSRDRAADGSMATEYLIKWSG 340

  Fly   323 LDDDDNDAGDKAVVEDEQ-----------------KDLLAKTPE-------PEVFSSDEEEEH-- 361
            |...|....|:.:|..||                 .::|.|.|:       |:...:|.|..|
 Worm   341 LPYSDCTWEDEKMVAPEQIKAYYHRIENLKSPNKNSNVLRKRPKFEKFESMPDFLKTDGESTHKL 405

  Fly   362 --------------------------LSNG--------------RYPSANT-LVVCPMSVMCQWA 385
                                      :..|              ||..|.. |||.|:|.|..|.
 Worm   406 RDYQLEGLNWMVYAWCKGNSSILADEMGLGKTIQSISLLASLFHRYDLAGPYLVVVPLSTMAAWQ 470

  Fly   386 HEVASKVAQNAIRVLTFHGPNRHEIGIEAFRSYD------------LVITSYNLVVNELKRYGNT 438
            .|.|....:  :.::.:.|   ..:..:..|.|:            .::|:|.:::.: |.:
 Worm   471 KEFAQWAPE--MNLVVYMG---DVVSRDMIRQYEWFVGGTKKMKINAILTTYEILLKD-KAF--- 526

  Fly   439 SPLFAVYWNRVILDEAHIIRNSKTNCCNSVCQLRAHCHWALTGTPVQNRGVDVFALLRFVNVPNF 503
              |.::.|..:::||||.::|.::....|:.|.|.:....:||||:||...:::|||.|:....|
 Worm   527 --LSSIDWAALLVDEAHRLKNDESLLYKSLTQFRFNHKLLITGTPLQNSLKELWALLHFIMPEKF 589

  Fly   504 QDLQQWKKNLNESMLGHRRLNFI---IKPLMLRRTKQKLQASGDMPALPSLKIELICVQLSKTEM 565
            ...::::...|||  .|:.::.:   ::|.:|||.|:.::.|     ||. |.|    |:.:.:|
 Worm   590 DCWEEFETAHNES--NHKGISALHKKLEPFLLRRVKKDVEKS-----LPP-KTE----QILRVDM 642

  Fly   566 AVYQILSAISKKIFTQFLLQREKGNSDLNYYSLERTPQFIAGHMSDERYNEIYERFLKSLGYNPG 630
            ..:|       |.|.:::|.:       ||..|.:                             |
 Worm   643 TAHQ-------KQFYKWILTK-------NYRELSK-----------------------------G 664

  Fly   631 EKILGIYILVLLLRLRQFCCHPGLMIGMLRGALTAEDVQNVKVDASDVEGQLKMDVLAELDKFDE 695
            .|                        |.:.|.                     ::::.||.|
 Worm   665 VK------------------------GSINGF---------------------VNLVMELKK--- 681

  Fly   696 TDSEDDCCDEEDSTRRDGNFKLEVIKDEIKEENVPWDSGDDLPTASSFEDQLDSARALKLLNPQN 760
                  ||:....||:                               ::...|.|        |.
 Worm   682 ------CCNHASLTRQ-------------------------------YDHIYDDA--------QG 701

  Fly   761 PIFQFIRPSAKLKMVIDKLEELLTGTNDKIIVTSQWVSYLAIVRKRLQDLSWETLDFNGQLTAKE 825
            .:.|.::.|.|| :::|||...|.....::::.||.|..|.|:::.||...:.:...:|.:.|..
 Worm   702 RLQQLLKSSGKL-ILLDKLLCRLKDKGHRVLIFSQMVMMLDILQEYLQLRRFPSQRLDGSMRADL 765

  Fly   826 REIVLRDFNA-NNEKRVLLLSLTAGGVGLNLNVANHMLIVDLHWNPQLERQAQDRIYRYGQTKPT 889
            |:..|..:|| .:.....|||..|||:|:||..|:.::|.|..||||.:.||..|.:|.||||..
 Worm   766 RKQALDHYNAPGSTDFAFLLSTRAGGLGINLATADTVIIFDSDWNPQNDLQAMSRAHRIGQTKTV 830

  Fly   890 FIYRYMCQDTVEQRIKSLQDCKLEIAKVVL 919
            .|||.:.:.:||:.|......||.:..:|:
 Worm   831 NIYRLVTKGSVEEEIVERAKRKLVLDHLVI 860

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10445	NP_649751.2	HepA	<113..919	CDD:440319	187/957 (20%)
		DEAD-like_helicase_N	209..534	CDD:475120	81/451 (18%)
chd-1	NP_491994.2	CD1_tandem_CHD1-2_like	194..275	CDD:349313	10/91 (11%)
		CD2_tandem	308..363	CDD:349306	10/54 (19%)
		PLN03142	404..1245	CDD:215601	131/617 (21%)
		DUF4208	1298..1367	CDD:464035