Protein Alignment CG10445 and Hells

DIOPT Version :10

• Sequence 1: NP_649751.2
• Gene: CG10445 / 40938
• FlyBaseID: FBgn0037531
• Length: 945
• Species: Drosophila melanogaster
• Sequence 2: NP_032260.2
• Gene: Hells / 15201
• MGIID: 106209
• Length: 821
• Species: Mus musculus
• Alignment Length: 992
• Identity: 198/992 - (19%)
• Similarity: 357/992 - (35%)
• Gaps: 337/992 - (33%)

  Fly    41 EPVDSLELSGEYADNESAIFVSASE-YNEKKAQI-----------DQLVQKILTMEQQQRQLEEN 93
            |..:.||.:|  .:.|..:...|.: ::.:..:|           ..:..|.|..:.:|:||||.
Mouse    16 EEEEQLEAAG--LEKERKMLEEAQKSWDRESTEIRYRRLQHLLEKSNIYSKFLLTKMEQQQLEEQ 78

  Fly    94 ASETK-ELCDLKLHLEKLNARLEALGE--FLDTLRLREDQ----------QEI-----KIEDNSE 140
            ..:.| |.....|.|.:..:.::..||  .:...|.|||:          :||     |.:||.:
Mouse    79 KKKEKLEKKKRSLKLTEGKSLVDGNGEKPVMKKKRGREDESYNISEVMSKEEILSVAKKHKDNED 143

  Fly   141 --------LVDHTEQPKWSNLYSGLNRYRQKANHTAAQFYQHKSNIIDSLKTLYEPI-----QPR 192
                    .|:..::.|.||     :..:.:.:.|..|          :.|..::|:     ||.
Mouse   144 ESSSTTSLCVEDIQKNKDSN-----SMIKDRLSQTVRQ----------NSKFFFDPVRKCNGQPV 193

  Fly   193 PAIDDLEKQPALLLVRLLK-HQQSCLKWMQFRERQKISGGILADDMGLGKTLSMIALILASEETK 256
            |.     :||......::: :|...::|::......|: |||||:||||||:..||.|.
Mouse   194 PF-----QQPKHFTGGVMRWYQVEGMEWLRMLWENGIN-GILADEMGLGKTVQCIATIA------ 246

  Fly   257 NRKREEKKKALTLKWTQEFNRVYCKEIRKISMFDDEEESGKEEEQYEPPEKRTCHVKTKKINQFR 321
                                                                             
Mouse   247 ----------------------------------------------------------------- 246

  Fly   322 ILDDDDNDAGDKAVVEDEQKDLLAKTPEPEVFSSDEEEEHLSNGRYPSANTLVVCPMSVMCQWAH 386
                                 |:.:...|..|                   ||..|:|.:..|..
Mouse   247 ---------------------LMIQRGVPGPF-------------------LVCGPLSTLPNWMA 271

  Fly   387 EVASKVAQNAIRVLTFHG---------PNRHEIGIEAFRSYDLVITSYNLVVNELKRYGNTSPLF 442
            |.  |.....|..|.:||         .|.|: .....:.:.:|:||:.:.:.:      .:.|.
Mouse   272 EF--KRFTPEIPTLLYHGTREDRRKLVKNIHK-RQGTLQIHPVVVTSFEIAMRD------QNALQ 327

  Fly   443 AVYWNRVILDEAHIIRNSKTNCCNSVCQLRAHCHWALTGTPVQNRGVDVFALLRFVNVPNFQDLQ 507
            ..||..:|:||.|.|:|.|......:.:..|.....|||||:||...::::||.|:....|.||:
Mouse   328 HCYWKYLIVDEGHRIKNMKCRLIRELKRFNADNKLLLTGTPLQNNLSELWSLLNFLLPDVFDDLK 392

  Fly   508 QWKK-----NLNES---MLGHRR-------LNFIIKPLMLRRTKQKLQASGDMPALPSLKIELIC 557
            .::.     :|:|:   ::...|       |:.|:.|.:|||.|..:..  ::|  |..::.:..
Mouse   393 SFESWFDITSLSETAEDIIAKEREQNVLHMLHQILTPFLLRRLKSDVAL--EVP--PKREVVVYA 453

  Fly   558 VQLSKTEMAVYQILSAISKKIFTQFLLQ----------REKGNSDLNYYSLERTPQFIAGHMSDE 612
            ...:|.|:....|::.....:|.....:          :.:....:||..|::.|..:...:|..
Mouse   454 PLCNKQEIFYTAIVNRTIANMFGSCEKETVELSPTGRPKRRSRKSINYSELDQFPSELEKLISQI 518

  Fly   613 RYNEIYERFLKSLGYNPGEKILGIYILVLLLRLRQFCCHPGLMIGMLRGALTAEDVQNVKVDASD 677
            :.....||.:.. |..|.|..:.:.:..:::.||:.|.||.:                ::.....
Mouse   519 QPEVNRERTVVE-GNIPIESEVNLKLRNIMMLLRKCCNHPYM----------------IEYPIDP 566

  Fly   678 VEGQLKMDVLAELDKFDETDSEDDCCDEEDSTRRDGNFKLEVIKDEIKEENVPWDSGDDLPTASS 742
            |..:.|:|                    |:.....|.|
Mouse   567 VTQEFKID--------------------EELVTNSGKF--------------------------- 584

  Fly   743 FEDQLDSARALKLLNPQNPIFQFIRPSAKLKMVIDKLEELLTGTNDKIIVTSQWVSYLAIVRK-- 805
                                           :::|::...|.....|::|.||..|.|.|:..
Mouse   585 -------------------------------LILDRMLPELKKRGHKVLVFSQMTSMLDILMDYC 618

  Fly   806 RLQDLSWETLDFNGQLTAKEREIVLRDFNANNEKRVLLLSLTAGGVGLNLNVANHMLIVDLHWNP 870
            .|::..:..||  |.::..|||..:..||.:.:..:.|:|..|||:|:||..|:.::|.|..|||
Mouse   619 HLRNFIFSRLD--GSMSYSEREKNIYSFNTDPDVFLFLVSTRAGGLGINLTAADTVIIYDSDWNP 681

  Fly   871 QLERQAQDRIYRYGQTKPTFIYRYMCQDTVEQRIKSLQDCKLEIAKVVLPE---EGGEVTKCVGG 932
            |.:.|||||.:|.|||||..:||.:..:|::|:|......|.::.|:::.:   :||:      .
Mouse   682 QSDLQAQDRCHRIGQTKPVVVYRLVTANTIDQKIVERAAAKRKLEKLIIHKNHFKGGQ------S 740

  Fly   933 GL----NLAELKKLFEM 945
            ||    |..:.|:|.|:
Mouse   741 GLSQSKNFLDAKELMEL 757

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10445	NP_649751.2	HepA	<113..919	CDD:440319	172/872 (20%)
		DEAD-like_helicase_N	209..534	CDD:475120	67/349 (19%)
Hells	NP_032260.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	78..120		10/41 (24%)
		DEXHc_HELLS_SMARCA6	203..436	CDD:350767	69/353 (20%)
		PLN03142	204..>781	CDD:215601	156/782 (20%)
		helicase domain I	226..238		9/12 (75%)
		helicase domain Ia	258..266		4/7 (57%)
		helicase domain II	334..341		3/6 (50%)
		helicase domain III	363..370		5/6 (83%)
		helicase domain IV	429..439		5/9 (56%)
		helicase domain IVa	547..559		5/11 (45%)
		'helicase domain IVb	602..609		3/6 (50%)
		helicase domain V	655..668		7/12 (58%)
		helicase domain VI	686..693		5/6 (83%)