Protein Alignment CG10445 and Mi-2

DIOPT Version :10

• Sequence 1: NP_649751.2
• Gene: CG10445 / 40938
• FlyBaseID: FBgn0037531
• Length: 945
• Species: Drosophila melanogaster
• Sequence 2: XP_061510532.1
• Gene: Mi-2 / 1280662
• VectorBaseID: AGAMI1_012829
• Length: 2152
• Species: Anopheles gambiae
• Alignment Length: 936
• Identity: 192/936 - (20%)
• Similarity: 342/936 - (36%)
• Gaps: 291/936 - (31%)

  Fly    77 VQKILTMEQQQRQLEENASETKELCD-------------LKLHLEKLNARLEALGEF-LDT---L 124
            ||||||.....:.:..:...|.:...             :|.| ||.....:.:.|. ||.   |
Mosquito   549 VQKILTWRWTDKPINPDEPSTSKGAAAAAGGSTRRREYFVKWH-EKSYWHCDWITELQLDVHHPL 612

  Fly   125 RLREDQQEIKIEDNSELVDHTEQPKWSNLYSGLNRYRQ---KANHTAAQFYQHKSNIIDSLKTLY 186
            ..|...::..:|:..:|.:..::.  .|.|..:.|.|:   :.|.|..:...::..:
Mosquito   613 MFRYYTRKNDMEEPPKLEEALDEE--DNRYKRIQRMRETNCQLNETELEEKYYRYGV-------- 667

  Fly   187 EPIQPRPAIDDLEKQPALLLV-RLLKHQQS-------CLKWMQFR--------ERQKISGGILAD 235
                          :|..|:| |::.|:..       .:||.:..        |...|:|..:|.
Mosquito   668 --------------KPEWLMVHRVINHRTMRDGRTLYLVKWRELSYDQATWEDEEDDIAGLKMAI 718

  Fly   236 DMGLGKTLSMIALILASEETKNRKREEKKKALTLKWTQEFNRVYCKEIRKISMFDDEEESGKEEE 300
            :..|....:....|..|....:...::.||               |..|::...::||.:...:.
Mosquito   719 EYYLDLRANCSQDIGGSGSGGSGSSKKNKK---------------KGRRRLRELEEEERTAGVKR 768

  Fly   301 QYEPPEKRTCHVKTKKINQFRILDDDDNDA-----------------GDKAVVEDEQKDLLAKTP 348
            ...||||.|..:|.|...|...||:.....                 |...::.||..  |.||.
Mosquito   769 YTPPPEKPTTDLKRKFEVQPPYLDETGMRLHPYQLEGINWLRYSWANGTDTILADEMG--LGKTI 831

  Fly   349 EPEVFSSDEEEEHLSNGRYPSANTLVVCPMSVMCQWAHE-------------VASKVAQNAIR-- 398
            :...|.....:|....|.:     ||..|:|.:..|..|             |..|.::..||
Mosquito   832 QTATFLYSLYKEGHCRGPF-----LVAVPLSTIINWEREFETWAPDFYCITYVGDKESRAVIREN 891

  Fly   399 VLTF-----HGPNRHEIGIEAFRSYDLVITSYNLVVNELKRYGNTSPLFAVYWNRVILDEAHIIR 458
            .|:|     .|.....|...:.: :::::|||.|:..:....|      ::.|:.:::||||.::
Mosquito   892 ELSFEEGAVRGGKASRIRASSIK-FNVLLTSYELISIDAACLG------SIDWSVLVVDEAHRLK 949

  Fly   459 NSKT------NCCNSVCQLRAHCHWALTGTPVQNRGVDVFALLRFVNVPNFQDLQQWKKNL---- 513
            ::::      |..|...:|      .|||||:||...::|.||.|:|...|.:|.:::...
Mosquito   950 SNQSKFFKVLNAYNIAYKL------LLTGTPLQNNLEELFHLLNFLNKSKFNELAEFQNEFADIS 1008

  Fly   514 NESMLGHRRLNFIIKPLMLRRTKQKLQASGDMPALPSLKIELICVQLSKTEMAVYQILSAISKKI 578
            .|..:  :||:.::.|.||||                ||.:::....:|:|..|...||.:.||.
Mosquito  1009 KEEQV--KRLHEMLGPHMLRR----------------LKADVLKNMPTKSEFIVRVELSPLQKKY 1055

  Fly   579 FTQFLLQREKGNSDLNYYSLERTPQFIAGHMSDERYNEIYERFLKSLGYNPGEKILGIYILVLLL 643
            : :::|.|       ||.:|  .|:...|..|                           ::.:::
Mosquito  1056 Y-KYILTR-------NYEAL--NPKGGGGACS---------------------------LINIMM 1083

  Fly   644 RLRQFCCHPGLMIGMLRGALTAEDVQNVKVDASDVEGQLKMDVLAELDKFDETDSEDDCCDEEDS 708
            .|::.|.||.|.      |..||:.|
Mosquito  1084 DLKKCCNHPYLF------AAAAEEAQ--------------------------------------- 1103

  Fly   709 TRRDGNFKLEVIKDEIKEENVPWDSGDDLPTASSFEDQLDSARALKLLNPQNPIFQFIRPSAKLK 773
            ....||::|:                                             ...:.:.||
Mosquito  1104 LGPGGNYELQ---------------------------------------------SLTKAAGKL- 1122

  Fly   774 MVIDKLEELLTGTNDKIIVTSQWVSYLAIVRKRLQDLSWETLDFNGQLTAKEREIVLRDFNANNE 838
            ::::|:..||.....::::.||....|.|:...|:.|.::....:|.:|...|:..:..|||...
Mosquito  1123 VLLEKMLRLLKSQGHRVLIFSQMTKMLDILEDFLEGLGYKYERIDGGITGSIRQEAIDRFNAPGA 1187

  Fly   839 KR-VLLLSLTAGGVGLNLNVANHMLIVDLHWNPQLERQAQDRIYRYGQTKPTFIYRYMCQDTVEQ 902
            .: ..|||..|||:|:||..|:.::|.|..|||..:.||..|.:|.||.....|||::.:::||:
Mosquito  1188 PQFCFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRIGQANKVMIYRFVTRNSVEE 1252

  Fly   903 RIKSLQDCKLEIAK-VVLPEEGGEVT 927
            |:..:...|:.:.. ||.|..||:.|
Mosquito  1253 RVTQVAKRKMMLTHLVVRPGMGGKGT 1278

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10445	NP_649751.2	HepA	<113..919	CDD:440319	176/877 (20%)
		DEAD-like_helicase_N	209..534	CDD:475120	82/386 (21%)
Mi-2	XP_061510532.1	None