Protein Alignment CG10445 and Etl1

DIOPT Version :10

• Sequence 1: NP_649751.2
• Gene: CG10445 / 40938
• FlyBaseID: FBgn0037531
• Length: 945
• Species: Drosophila melanogaster
• Sequence 2: XP_061519079.1
• Gene: Etl1 / 1279402
• VectorBaseID: AGAMI1_014601
• Length: 868
• Species: Anopheles gambiae
• Alignment Length: 1048
• Identity: 225/1048 - (21%)
• Similarity: 376/1048 - (35%)
• Gaps: 358/1048 - (34%)

  Fly     2 ESSSPSDTTEIHKQSCSIQDQSSVPVPDSSGEINNWMEPEP---------------------VDS 45
            :|.|.:.||.|          ..||:|.......|.....|                     ||:
Mosquito    41 DSESDASTTPI----------KPVPIPVVGAVKENGATKSPAALTIKEKELRLQKVRQACMEVDA 95

  Fly    46 LELSGEYADNESAIFVSASEYN----EKKAQIDQLVQKILTME---------QQQ----RQLEEN 93
            :.|......||..:..:..|..    ::|..:.....|..|.|         |||    |..|.|
Mosquito    96 MLLQSSLVSNEWDVDKAIEELKKTAVKRKIIVSPSPVKPATAETATNGKEKNQQQAKKRRVQEPN 160

  Fly    94 ASETKELCDLKLHLEKL--------------------NARLEALGEFLDTLRLRE-------DQQ 131
            .|:.:...|.....|::                    |.|...| |||:|..|.|       ..:
Mosquito   161 RSDDESDVDSDRPAEQVFDSDEDSDGHGGSYSHGKLSNERKNVL-EFLNTAGLNEMICVKTLSMK 224

  Fly   132 EIKIEDNSELVDHTEQPKWSNLYSGLNRYRQK----ANHTAAQFYQHKSNIIDSL-------KTL 185
            :|::     |::......||||...|..:|..    .|:| .::...:.||...:       |.|
Mosquito   225 KIEL-----LLEQRPFKDWSNLVDKLKSHRSLQTDILNYT-QEYLTRRKNIAAMMSKCKKITKKL 283

  Fly   186 YEPIQPRPAIDDLEKQPALLL--VRLLKHQQSCLKWMQFRERQKISGGILADDMGLGKTLSMIAL 248
            .|.|  ......|.:||..:.  .:|.::|...|.|:....|.|:: .||||:||||||:.:||.
Mosquito   284 EEAI--ASGSGTLVEQPGNIADGFKLAEYQLVGLNWLTIMYRHKMN-AILADEMGLGKTIQIIAF 345

  Fly   249 ILASEETKNRKREEKKKALTLKWTQEFNRVYCKEIRKISMFDDEEESGKEEEQYEPPEKRTCHVK 313
                                |.|.                        ||....|.|
Mosquito   346 --------------------LAWL------------------------KENNHQERP-------- 358

  Fly   314 TKKINQFRILDDDDNDAGDKAVVEDEQKDLLAKTPEPEVFSSDEEEEHLSNGRYPSANTLVVCPM 378
                                                                      .|||.|.
Mosquito   359 ----------------------------------------------------------NLVVVPS 365

  Fly   379 SVMCQWAHEVASKVAQNAIRVLTFHG--PNRHEIGIE----AFRSYDLVITSYNLVVNELKRYGN 437
            |.|..|..|:.....:  :.:|.::|  ..|..|.::    .....|:|:|:|::    :...|.
Mosquito   366 STMDNWEQELVKWCPE--LVILKYYGSQAERRMIRVDWAKNGINEVDVVLTTYHM----MGASGE 424

  Fly   438 TSPLFAV-YWNRVILDEAHIIRNSKTNCCNSVCQLRAHCHWALTGTPVQNRGVDVFALLRFV--- 498
            ...::.| .::.|:.||||:::|..:....::.::.|.....|||||:||..:::.:||.||
Mosquito   425 EKKMWRVTQFDYVVFDEAHMLKNVHSQRYQNLIRINAKYRILLTGTPLQNNLLELMSLLCFVMPK 489

  Fly   499 ----NVPNFQDLQQWKKNLNESMLGHRRLN-----------FIIKPLMLRRTKQKLQASGDMPAL 548
                .|.:.:.|.|.|...|:.. |...|:           .|:||.:|||.|:.:.|     .|
Mosquito   490 LIGSKVEDIKTLFQGKVKTNKGE-GEEELSSFEKNQIDRAKLIMKPFVLRRLKKDVLA-----FL 548

  Fly   549 PSLKIELICVQLSKTEMAVYQILSAISKKIFTQFLLQREKGNSDLNYYSLERTPQFIAGHMSDER 613
            |..| |::.    ||.|        |..        |:||.|..:|.|      |...|.:.|
Mosquito   549 PPKK-EVVL----KTSM--------IDS--------QQEKYNEIVNEY------QNATGKVKD-- 584

  Fly   614 YNEIYERFLKSLGYNPGEKILGIYILVLLLRLRQFCCHPGLMIGMLRGALTAEDVQNVK---VDA 675
            |.||..                   :.:::.||:...||.|    ||...:.:||:|:.   ...
Mosquito   585 YTEISG-------------------MSIMMDLRKLANHPLL----LRYYYSDDDVRNIARKLATD 626

  Fly   676 SDVEGQLKMDVLAELDKFDETDSEDDCCDEEDSTRRDGNFKLEVIKDEIKEENVPWDSGDDLPTA 740
            .|.:|..:.|:..::....:                   |||..::|:.               .
Mosquito   627 PDYKGTKEDDIFYDIAYLSD-------------------FKLYEMRDKY---------------T 657

  Fly   741 SSFEDQLDSARALKLLNPQNPIFQFIRPSAKLKMVIDKLEELLTGTND---KIIVTSQWVSYLAI 802
            :.::.||          |:    :.|..|.|.:    :|:|||....:   ::::.||:...|.|
Mosquito   658 TLYDLQL----------PE----KLITSSGKFR----QLDELLPKMKEEGHRVLIFSQFTMMLDI 704

  Fly   803 VRKRLQDLSWETLDFNGQLTAKEREIVLRDFNANNEKRVLLLSLTAGGVGLNLNVANHMLIVDLH 867
            :.:.|:......|..:|.....||:.::..:..:.:..:.|||..|||:|:||..|:.::|.|:.
Mosquito   705 MERYLKIRKHGFLRLDGSTAVTERQELIDQYTQDPDLFIFLLSTKAGGLGINLTAADTVIIHDID 769

  Fly   868 WNPQLERQAQDRIYRYGQTKPTFIYRYMCQDTVEQRIKSLQDCKLEIAKVVLPEEGG---EVTKC 929
            :||..::||:||.:|.||.||..||:.:.:.|:|:.:..:...||::.|.|..::|.   :..||
Mosquito   770 FNPYNDKQAEDRAHRMGQKKPVTIYKLISEGTIEEGMLMIAQQKLQLEKDVTEQDGKNPMDDHKC 834

  Fly   930 VGGGLNLA 937
            :.|.|.:|
Mosquito   835 MVGLLTMA 842

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10445	NP_649751.2	HepA	<113..919	CDD:440319	188/856 (22%)
		DEAD-like_helicase_N	209..534	CDD:475120	71/349 (20%)
Etl1	XP_061519079.1	None