Protein Alignment CG10445 and SRCAP

DIOPT Version :10

• Sequence 1: NP_649751.2
• Gene: CG10445 / 40938
• FlyBaseID: FBgn0037531
• Length: 945
• Species: Drosophila melanogaster
• Sequence 2: NP_006653.2
• Gene: SRCAP / 10847
• HGNCID: 16974
• Length: 3230
• Species: Homo sapiens
• Alignment Length: 693
• Identity: 137/693 - (19%)
• Similarity: 231/693 - (33%)
• Gaps: 288/693 - (41%)

  Fly     3 SSSPSDTTEIHKQSCSIQDQSSV-----PVPDSSGEINNWMEPEPVDSLELSGEYADNESAIFVS 62
            ||...|..|:...|...:.:..|     |..|||.:.:: :|....|.   ..|:::.|.....|
Human   461 SSEDEDEDEVDANSSDCEPEGPVEAEEPPQEDSSSQSDS-VEDRSEDE---EDEHSEEEETSGSS 521

  Fly    63 ASEYNEKKAQIDQLVQKILTMEQQQRQLEENASETKELCDLKLHLEKLNARLEALGEFLDTLRLR 127
            |||.:|.:             |.:..|.:..|.|.:|  |....:|.|.||             .
Human   522 ASEESESE-------------ESEDAQSQSQADEEEE--DDDFGVEYLLAR-------------D 558

  Fly   128 EDQQE------------IKIEDNSELVD-----HTEQPKWSNLYSGLNRYRQKANHTAAQFYQHK 175
            |:|.|            ..:....|:.|     .:.|||               .:|.|
Human   559 EEQSEADAGSGPPTPGPTTLGPKKEITDIAAAAESLQPK---------------GYTLA------ 602

  Fly   176 SNIIDSLKTLYEPIQPRPAIDDLEKQPALLLVRLLKHQQSCLKWMQFRERQKISGGILADDMGLG 240
               ...:||   ||            |.||..:|.::|...|.|:.....:|:: |||||:||||
Human   603 ---TTQVKT---PI------------PLLLRGQLREYQHIGLDWLVTMYEKKLN-GILADEMGLG 648

  Fly   241 KTLSMIALILASEETKNRKREEKKKALTLKWTQEFNRVYCKEIRKISMFDDEEESGKEEEQYEPP 305
            ||:..|:|:
Human   649 KTIQTISLL-------------------------------------------------------- 657

  Fly   306 EKRTCHVKTKKINQFRILDDDDNDAGDKAVVEDEQKDLLAKTPEPEVFSSDEEEEHLSNGRYPSA 370
                .|:..:|.|.                                             |.:
Human   658 ----AHLACEKGNW---------------------------------------------GPH--- 670

  Fly   371 NTLVVCPMSVMCQWAHEVASKVAQNAIRVLTFHGPNRH----EIGIEAFRSYDLVITSYNLVVNE 431
              |::.|.|||..|  |:..|....:.::||::|..:.    ..|.....::.:.||||.||:.:
Human   671 --LIIVPTSVMLNW--EMELKRWCPSFKILTYYGAQKERKLKRQGWTKPNAFHVCITSYKLVLQD 731

  Fly   432 LKRYGNTSPLFAVYWNRVILDEAHIIRNSKTNCCNSVCQLRAHCHWALTGTPVQNRGVDVFALLR 496
            .:.:...:      |..:|||||..|:|.|:....|:....:.....|||||:||..:::::|:.
Human   732 HQAFRRKN------WRYLILDEAQNIKNFKSQRWQSLLNFNSQRRLLLTGTPLQNSLMELWSLMH 790

  Fly   497 FVNVPNFQ---DLQQWKKN-----------LNESMLGHRRLNFIIKPLMLRRTKQKLQASGDMPA 547
            |:....||   :.::|..|           .||.::  :||:.:::|.:|||.|..::..
Human   791 FLMPHVFQSHREFKEWFSNPLTGMIEGSQEYNEGLV--KRLHKVLRPFLLRRVKVDVEKQ----- 848

  Fly   548 LPSLKIELICVQLSKTEMAVYQILSAISKKIFTQFLLQREKGNSDLNYYSLERTPQFIA-GHMSD 611
            :|.....:|..:|||.:..:|.           .|:.|             ..|.:.:| ||.
Human   849 MPKKYEHVIRCRLSKRQRCLYD-----------DFMAQ-------------TTTKETLATGHF-- 887

  Fly   612 ERYNEIYERFLKSLGYNPGEKILGIYILVLLLRLRQFCCHPGL 654
                                    :.::.:|::||:.|.||.|
Human   888 ------------------------MSVINILMQLRKVCNHPNL 906

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10445	NP_649751.2	HepA	<113..919	CDD:440319	109/578 (19%)
		DEAD-like_helicase_N	209..534	CDD:475120	69/342 (20%)
SRCAP	NP_006653.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..71
		HSA	127..193	CDD:462194
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	253..547		24/104 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	559..581		3/21 (14%)
		DEXQc_SRCAP	618..840	CDD:350761	69/342 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1017..1045
		PHA03247	<1031..1592	CDD:223021
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1058..1125
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1138..1166
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1320..1366
		PHA03247	<1366..1834	CDD:223021
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1406..1425
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1629..1760
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1839..1893
		SF2_C_SNF	2032..2167	CDD:350180
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2214..2233
		COG4372	2241..>2362	CDD:443500
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2271..2298
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2327..2453
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2564..2583
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2598..3081
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	3095..3230