Protein Alignment CG10445 and chd8

DIOPT Version :10

• Sequence 1: NP_649751.2
• Gene: CG10445 / 40938
• FlyBaseID: FBgn0037531
• Length: 945
• Species: Drosophila melanogaster
• Sequence 2: XP_012812626.1
• Gene: chd8 / 100192376
• XenbaseID: XB-GENE-966847
• Length: 2335
• Species: Xenopus tropicalis
• Alignment Length: 970
• Identity: 210/970 - (21%)
• Similarity: 331/970 - (34%)
• Gaps: 370/970 - (38%)

  Fly    25 VPVPDSSGEINNWMEPEPVDSLELSGEYADNESAI-------------------FVSASEYNEKK 70
            :|:|||          |.|.|::...|....|.|.                   :|...||..|.
 Frog   562 MPLPDS----------EAVPSMQFFVENPSEEDAAIVDKILSMRLAKKELPTGEYVEVEEYFVKY 616

  Fly    71 AQIDQLVQKILTMEQQQRQLEENASETKELCDLKLH--LEKLNARLEALGEFL--DTLRLREDQQ 131
            .....|..:..|:||.:|             |.::|  |::...::..:..||  |......|..
 Frog   617 KNYSYLHCEWATIEQLER-------------DKRIHQKLKRFKTKMTQMQHFLQEDEESFNPDYV 668

  Fly   132 EI-KIEDNSELVDHTE-QP------KWSNLYSGLNRYRQKANHTAAQFYQHKSNI----IDSLKT 184
            |: :|.|.|...|... :|      ||.:|     .|....       ::.|.::    |:..|.
 Frog   669 EVDRILDESHSTDKDNGEPVVYYLVKWCSL-----PYEDST-------WELKEDVDDGKIEEFKR 721

  Fly   185 LYEPIQP------RPAIDDLEKQPALLLVR-------LLKHQQSCLKWMQFR--ERQKISGGILA 234
            : |..||      |||....:|   |.|.|       |.::|...:.|:.|.  .||..   |||
 Frog   722 I-EARQPNLKRVARPAATSWKK---LELSREYQNGNQLREYQLEGVNWLLFNWYNRQNC---ILA 779

  Fly   235 DDMGLGKTLSMIALILASEETKNRKREEKKKALTLKWTQEFNRVYCKEIRKISMFDDEEESGKEE 299
            |:||||||:..|..:                       ||   ||...||
 Frog   780 DEMGLGKTIQSITFL-----------------------QE---VYNVGIR--------------- 803

  Fly   300 EQYEPPEKRTCHVKTKKINQFRILDDDDNDAGDKAVVEDEQKDLLAKTPEPEVFSSDEEEEHLSN 364
                                                                             
 Frog   804 ----------------------------------------------------------------- 803

  Fly   365 GRYPSANTLVVCPMSVMCQWAHEVASKVAQNAIRVLTFHGPNRHEIGIEAFRSY----------- 418
            |.:     ||:.|:|.:..|..|..|....|.|   .:||.......|:.:..|
 Frog   804 GPF-----LVIAPLSTITNWEREFGSWTQMNTI---VYHGSLASRQMIQQYEMYCKDSKGRLIPG 860

  Fly   419 ----DLVITSYNLVVNELKRYGNTSPLFAVYWNRVILDEAHIIRNSKTNCCNSVCQLRAHCHWAL 479
                |.:||::.:|:::...      |..:.|..||:||||.::|......:|:..:.......|
 Frog   861 AYKFDALITTFEMVLSDCPE------LREIEWRCVIIDEAHRLKNRNCKLLDSLKHMDLEHKVLL 919

  Fly   480 TGTPVQNRGVDVFALLRFVNVPNFQDLQQWKKNLNESMLGH--RRLNFIIKPLMLRRTKQKLQAS 542
            ||||:||...::|:||.|:....|....::.|:..:.....  ::|..|:||:||||.|:.::.:
 Frog   920 TGTPLQNTVEELFSLLHFLEPTQFSSEAEFLKDFGDLKTEEQVQKLQAILKPMMLRRLKEDVEKN 984

  Fly   543 GDMPALPSLKIELICVQLSKTEMAVYQILSAISKKIFTQFLLQREKGNSDLNYYSLERTPQFIAG 607
                 |...:..:|.|:|:..:...|:   ||.:|.|: ||   .||.|..|      ||.
 Frog   985 -----LAPKQETIIEVELTNIQKKYYR---AILEKNFS-FL---TKGASQSN------TPN---- 1027

  Fly   608 HMSDERYNEIYERFLKSLGYNPGEKILGIYILVLLLRLRQFCCHPGLMIGMLRGALTAEDVQNVK 672
                                          :|..::.||:.|.||.|:.|
 Frog  1028 ------------------------------LLNTMMELRKCCNHPYLITG--------------- 1047

  Fly   673 VDASDVEGQLKMDVLAELDKFDETDSEDDCCDEEDSTRRDGNFKLEVIKDEIKEENVPWDSGDDL 737
                           ||                            |.|..|.:|
 Frog  1048 ---------------AE----------------------------EKIISEFRE----------- 1058

  Fly   738 PTASSFEDQLDSARALKLLNPQNPIFQFIRPSAKLKMVIDKLEELLTGTNDKIIVTSQWVSYLAI 802
                          |..::.|...:...:|.|.|| ::||||...|.....|:::.||.|..|.|
 Frog  1059 --------------ATPVVPPDFHVQAMVRSSGKL-VLIDKLLPKLRAGGHKVLIFSQMVRCLDI 1108

  Fly   803 VRKRL--QDLSWETLDFNGQLTAKEREIVLRDFN-ANNEKRVLLLSLTAGGVGLNLNVANHMLIV 864
            :...|  :...:|.:|  |::....|:..:..|: .::::.|.||...|||:|:||..|:..:|.
 Frog  1109 LEDYLIQRRYLYERID--GRVRGNMRQAAIDRFSRPDSDRFVFLLCTRAGGLGINLTAADTCIIF 1171

  Fly   865 DLHWNPQLERQAQDRIYRYGQTKPTFIYRYMCQDTVEQRIKSLQDCKLEIAKVVLPEEGG 924
            |..||||.:.|||.|.:|.||:|...|||.:.:::.|:.:......||.:.|.||....|
 Frog  1172 DSDWNPQNDLQAQARCHRIGQSKAVKIYRLITRNSYEREMFDKASLKLGLDKAVLQSMSG 1231

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10445	NP_649751.2	HepA	<113..919	CDD:440319	185/854 (22%)
		DEAD-like_helicase_N	209..534	CDD:475120	70/343 (20%)
chd8	XP_012812626.1	Med15	35..>363	CDD:312941
		CD1_tandem_CHD5-9_like	582..647	CDD:349315	14/77 (18%)
		CD2_tandem_CHD5-9_like	665..723	CDD:349310	14/70 (20%)
		PLN03142	754..>1357	CDD:215601	161/739 (22%)
		DEXHc_CHD8	755..976	CDD:350818	70/343 (20%)
		BRK	2122..2165	CDD:462196