DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2678 and ZNF574

DIOPT Version :9

Sequence 1:	NP_649750.1	Gene:	CG2678 / 40937	FlyBaseID:	FBgn0014931	Length:	434	Species:	Drosophila melanogaster
Sequence 2:	NP_001317448.1	Gene:	ZNF574 / 64763	HGNCID:	26166	Length:	986	Species:	Homo sapiens

Alignment Length:	395	Identity:	89/395 - (22%)
Similarity:	144/395 - (36%)	Gaps:	74/395 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 QSEQSYQHFFRVLNQSGAPENQVHLAACNGD----------KNQIINQKMQLKSD---------- 121
            |:..:.:|.:|...:.|........||...:          |....:|..||.:|
Human   264 QARVAVEHSYRKAEEGGEGATVPSAAATTTEVVTEVELLLYKCSECSQLFQLPADFLEHQATHFP 328

  Fly   122 ----------RQQDTQQMTKTQKPDDDLSQKQTLQA-----KLQEGNIDGPPESFTLHPRKRTCR 171
                      .||:.|..:..:.|   :||...|.|     :|:.|...|         |.|..|
Human   329 APVPESQEPALQQEVQASSPAEVP---VSQPDPLPASDHSYELRNGEAIG---------RDRRGR 381

  Fly   172 TEEQADMIPKEATRSTKMICDADGYYNCPHCSKRFCSQTQLRTHI---TDLCNRCPYCPRTYMQK 233
            ...:.:........:.::.|.|        |.:.|.|..||:.|:   .:...:||.|.|.:...
Human   382 RARRNNSGEAGGAATQELFCSA--------CDQLFLSPHQLQQHLRSHREGVFKCPLCSRVFPSP 438

  Fly   234 SNLKRHLRNHLSKPAHKCFHCSKAFMRKDHLKRHLRTHDSDGPLSCSQCSAVFIEHVQLEIHRRE 298
            |:|.:||.:|.|:....|..|..||..:..|..|.|.| :..||....|...|:...:...|||.
Human   439 SSLDQHLGDHSSESHFLCVDCGLAFGTEALLLAHRRAH-TPNPLHSCPCGKTFVNLTKFLYHRRT 502

  Fly   299 H---------KQRPGSSKSESTKDPDSDDSDQAQDLKPKWTKNTFNGTCSIPPMLKPKPICDICQ 354
            |         ...|.........:|...::.:.:..:|..::.|..|..: |...:    |.:|.
Human   503 HGVGGVPLPTTPVPPEEPVIGFPEPAPAETGEPEAPEPPVSEETSAGPAA-PGTYR----CLLCS 562

  Fly   355 KKFSSVYALKRHMLTHNRQHHLKKCTYCSEEFKTEKHLKRHERGHMGDL-FRCEFCSLVFVDVNY 418
            ::|.....|.||....:|.....||:.|.:.||.:.|::.|.|.|.|:. |.|..||..|.....
Human   563 REFGKALQLTRHQRFVHRLERRHKCSICGKMFKKKSHVRNHLRTHTGERPFPCPDCSKPFNSPAN 627

  Fly   419 LRKHK 423
            |.:|:
Human   628 LARHR 632

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2678	NP_649750.1	zf-AD	8..85	CDD:214871	1/7 (14%)
		COG5048	220..>284	CDD:227381	21/63 (33%)
		C2H2 Zn finger	223..243	CDD:275368	8/19 (42%)
		zf-C2H2	249..271	CDD:278523	7/21 (33%)
		C2H2 Zn finger	251..271	CDD:275368	7/19 (37%)
		C2H2 Zn finger	279..299	CDD:275368	5/19 (26%)
		C2H2 Zn finger	350..370	CDD:275368	6/19 (32%)
		C2H2 Zn finger	379..399	CDD:275368	7/19 (37%)
		C2H2 Zn finger	406..427	CDD:275368	6/18 (33%)
ZNF574	NP_001317448.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910