DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2678 and AgaP_AGAP011332

DIOPT Version :9

Sequence 1:	NP_649750.1	Gene:	CG2678 / 40937	FlyBaseID:	FBgn0014931	Length:	434	Species:	Drosophila melanogaster
Sequence 2:	XP_001237211.2	Gene:	AgaP_AGAP011332 / 4577561	VectorBaseID:	AGAP011332	Length:	323	Species:	Anopheles gambiae

Alignment Length:	420	Identity:	89/420 - (21%)
Similarity:	145/420 - (34%)	Gaps:	147/420 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 KNVCRTCMDETGTLVDIFAN--VRDPVLDEPEMSLSHILARCTERPVKRGDLLPQFICVSCVLAV 68
            :||||.|: ....:|.:|.|  :.:.::|..::.|.         .|...|.||..:|..|...:
Mosquito    13 ENVCRFCL-SLEDIVPLFINSTINEILIDAVDVLLP---------KVDEHDGLPNCVCARCHQRM 67

  Fly    69 QNAFRFKWQSEQSY---QHFFRVLNQSGAPENQVHLAACNGDKNQIINQKMQLKSDRQQDTQQMT 130
            .:..:|:..:.:.|   |.....|::.|..        ||...     |.|.
Mosquito    68 ADFSKFEATALEVYNKLQSVIAYLDEEGDD--------CNAGP-----QPMH------------- 106

  Fly   131 KTQKPDDDLSQKQTLQAKLQEGNIDGPP---ESFTL---------HPRKRTCRTEEQADMIPKEA 183
                 :||.:.:........|   |||.   ||..|         ||..:..|.       ||:|
Mosquito   107 -----EDDANDQLEPPPNAIE---DGPAQEMESIALETEIAATKTHPASKPTRR-------PKKA 156

  Fly   184 TRSTKMICDADGYYNCPHCSKRFCSQTQLRTHI---TDLCNR--CPYCPRTYMQKSNLKRHLRNH 243
                           ||.|.|..   :|:..|:   :....|  |..|.:.:...::|::||:.|
Mosquito   157 ---------------CPVCGKLV---SQISKHMSVHSSATKRFACEQCDKRFTLLASLRKHLKIH 203

  Fly   244 LSKPAHKCFHCSKAFMRKDHLKRHLRTHDSDGPLSCSQCSAVFIEHVQLEIHRR-EHKQRPGSSK 307
            .:...::|.||..:|..:..|:.||..|......:|..|...|....|.:.|:| .|::|
Mosquito   204 RNIRNYRCEHCGDSFCDRSSLRYHLAKHRGVPGFACEFCDRQFYTSSQWKQHQRLAHRER----- 263

  Fly   308 SESTKDPDSDDSDQAQDLKPKWTKNTFNGTCSIPPMLKPKPICDICQKKFSSVYALKRHMLTHNR 372
                                     ||.              ||:|.:.|    .||.|::.|.:
Mosquito   264 -------------------------TFR--------------CDVCGQAF----LLKHHLMEHAQ 285

  Fly   373 QH-----HLKKCTYCSEEFKTEKHLKRHER 397
            .|     |  :|..|.:.||.|::|..|:|
Mosquito   286 LHTDGRPH--ECDVCGKAFKRERYLHVHKR 313

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2678	NP_649750.1	zf-AD	8..85	CDD:214871	18/81 (22%)
		COG5048	220..>284	CDD:227381	17/65 (26%)
		C2H2 Zn finger	223..243	CDD:275368	5/19 (26%)
		zf-C2H2	249..271	CDD:278523	7/21 (33%)
		C2H2 Zn finger	251..271	CDD:275368	7/19 (37%)
		C2H2 Zn finger	279..299	CDD:275368	6/20 (30%)
		C2H2 Zn finger	350..370	CDD:275368	7/19 (37%)
		C2H2 Zn finger	379..399	CDD:275368	8/19 (42%)
		C2H2 Zn finger	406..427	CDD:275368
AgaP_AGAP011332	XP_001237211.2	zf-AD	15..86	CDD:285071	17/80 (21%)
		C2H2 Zn finger	157..174	CDD:275368	6/19 (32%)
		C2H2 Zn finger	183..203	CDD:275368	5/19 (26%)
		C2H2 Zn finger	211..231	CDD:275368	7/19 (37%)
		C2H2 Zn finger	239..259	CDD:275368	6/19 (32%)
		C2H2 Zn finger	267..287	CDD:275368	8/23 (35%)
		C2H2 Zn finger	295..316	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910