DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2678 and CG7963

DIOPT Version :9

Sequence 1:	NP_649750.1	Gene:	CG2678 / 40937	FlyBaseID:	FBgn0014931	Length:	434	Species:	Drosophila melanogaster
Sequence 2:	NP_649798.3	Gene:	CG7963 / 41001	FlyBaseID:	FBgn0037584	Length:	354	Species:	Drosophila melanogaster

Alignment Length:	436	Identity:	101/436 - (23%)
Similarity:	160/436 - (36%)	Gaps:	115/436 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 CRTCMDETGTLVDIFANVRDPVLDEPEMSLSHILARCTERPVKRGDLLPQFICVSCVLAVQNAFR 73
            ||.|:.:...||||:     .:::|.::.|..:|..|....|.|.|:.|.::|..|...:..|.:
  Fly    10 CRVCLKQDELLVDIY-----EIVEEMQVDLCTLLETCGGIKVDRRDVQPMYLCQECTNELLIAAK 69

  Fly    74 FK---WQSEQSYQHFFRVLNQSGAPENQVHLAACNGDKNQIINQKMQLKSDRQQDTQQMTKTQKP 135
            |:   .:||:.         :..|||..:..|.....:..||       .|.....:|::..:.|
  Fly    70 FRKICVESEKL---------RDMAPEINIDTAEPLASEEIII-------IDPSDYIEQLSAVEDP 118

  Fly   136 DDDLSQKQTLQAKLQEGNIDGPPESFTLHPRKRTCRTEEQADMIPKEATRSTKMICDADGYYNCP 200
            :::                                         |...:|           :||.
  Fly   119 ENE-----------------------------------------PIGVSR-----------WNCQ 131

  Fly   201 HCSKRFCSQTQLRTHITDL-----CNRCPYCPRTYMQKSNLKRHLRNHLSKP--AHKCFHCSKAF 258
            ||...|.....||.||.::     ...|....|.:.:....:.|..::...|  .|||..|.|..
  Fly   132 HCGAGFQLSEVLRRHIQEVHASITIIDCRERRRIFTKLGCYQVHNCSYAKTPKRGHKCLECGKCL 196

  Fly   259 MRKDHLKRHLRTHDSDGPLSCSQCSAVFIEHVQLEIHRREHKQ-------RPGSSKSESTKDPDS 316
            .....|..|:|.|..:.|.:|.||:..|..:..||:|:|.|||       ..|....||
  Fly   197 QSASSLASHIRLHTDEWPFTCDQCAKAFRTNGALEVHQRRHKQVLQHKCLHCGRGFVES------ 255

  Fly   317 DDSDQAQDLKPKWTKNTFNGTCSIPPMLKPKP-ICDICQKKFSSVYALKRHMLTHNRQHHLKKCT 380
              |:..:.:..:.|:.              :| :|::.|:.||.||.|:.|:.| |.......|.
  Fly   256 --SNLRRHIVNRHTEE--------------RPHLCNVYQRSFSRVYMLELHLRT-NTGERPYACQ 303

  Fly   381 YCSEEFKTEKHLKRHERGHMGD-LFRCEFCSLVFVDVNYLRKHKKR 425
            :..:.|.....||.|||.|.|: |.||:.|...|.....||||..|
  Fly   304 HRDKRFAQLGVLKIHERIHTGERLHRCQVCEKPFTRAGQLRKHALR 349

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2678	NP_649750.1	zf-AD	8..85	CDD:214871	21/78 (27%)
		COG5048	220..>284	CDD:227381	17/65 (26%)
		C2H2 Zn finger	223..243	CDD:275368	3/19 (16%)
		zf-C2H2	249..271	CDD:278523	8/21 (38%)
		C2H2 Zn finger	251..271	CDD:275368	6/19 (32%)
		C2H2 Zn finger	279..299	CDD:275368	8/19 (42%)
		C2H2 Zn finger	350..370	CDD:275368	8/19 (42%)
		C2H2 Zn finger	379..399	CDD:275368	7/19 (37%)
		C2H2 Zn finger	406..427	CDD:275368	8/20 (40%)
CG7963	NP_649798.3	zf-AD	10..80	CDD:285071	21/74 (28%)
		C2H2 Zn finger	159..179	CDD:275368	3/19 (16%)
		COG5048	184..>250	CDD:227381	21/65 (32%)
		C2H2 Zn finger	189..209	CDD:275368	6/19 (32%)
		C2H2 Zn finger	217..237	CDD:275368	8/19 (42%)
		C2H2 Zn finger	245..262	CDD:275368	4/24 (17%)
		C2H2 Zn finger	274..294	CDD:275368	9/20 (45%)
		C2H2 Zn finger	302..322	CDD:275368	7/19 (37%)
		zf-H2C2_2	315..339	CDD:290200	12/23 (52%)
		C2H2 Zn finger	330..350	CDD:275368	8/20 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910