DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2678 and Neu2

DIOPT Version :9

Sequence 1:	NP_649750.1	Gene:	CG2678 / 40937	FlyBaseID:	FBgn0014931	Length:	434	Species:	Drosophila melanogaster
Sequence 2:	NP_649316.1	Gene:	Neu2 / 40375	FlyBaseID:	FBgn0037085	Length:	382	Species:	Drosophila melanogaster

Alignment Length:	395	Identity:	97/395 - (24%)
Similarity:	146/395 - (36%)	Gaps:	127/395 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 EPEMSLSHILARCTERPVKRGDLLPQFICVSCVLAVQNAFRFKWQSEQSYQHFFRVLNQSGAPEN 97
            ||.:|:::|:.:||...|::.|.|...||.||:...||||......|:|:| |:|.|......|:
  Fly    10 EPGLSIAYIIYKCTGWQVEKHDPLSNTICKSCLEDAQNAFDIIETYERSHQ-FYRFLKDVREEES 73

  Fly    98 QVHLAACNGDKNQIINQKMQLKSDRQQDTQQMTKTQKPDDDLSQKQTLQAKLQEG--NIDGPPES 160
            :...:.|:                                  .:.:..:..||:|  ::|...|
  Fly    74 ENDGSGCS----------------------------------EEVEAAERDLQDGADDVDSGNE- 103

  Fly   161 FTLHPRKRTCRTEEQADMIPKEATRSTKMICDADGYYNCPHCSKRFCSQTQLRTHITDLCNRCPY 225
                |....|      |:..||          ..|:                         .|.:
  Fly   104 ----PDINEC------DIKAKE----------KPGF-------------------------SCSH 123

  Fly   226 CPRTYMQKSNLKRHLRNHLSKPAHKCFHCSKAFMRKDHLKRHLRTHDSDGPLSCSQCSAVFIEHV 290
            ||:::..|||||.|:|:|..:....|..|.|:|.....|:.|:|||..:.|..||.|...|....
  Fly   124 CPKSFQVKSNLKVHMRSHTGERPFTCSLCPKSFGYSSGLQNHMRTHTGERPFQCSHCPRSFTAGH 188

  Fly   291 QLEIHRREHKQRPGSSKSESTKDPDSDDSDQAQDLKPKWTKNTFNGTCSIPPMLKPKPICDICQK 355
            .|:.|.:.|::| ||.:                                          |..|||
  Fly   189 HLKAHIQMHERR-GSLR------------------------------------------CPYCQK 210

  Fly   356 KFSSVYALKRHMLTHNRQHHLKKCTYCSEEFKTEKHLKRHERGHMGDLFRCEFCSLVFVDVNYLR 420
            .|.:...||:|:.||..:... ||:.||:.|:.|..|..|.|.|...||.|..||..|....||:
  Fly   211 CFLTSLILKQHLATHTDETQF-KCSQCSKSFQVEHELWMHMRVHQERLFTCGHCSKDFALHAYLK 274

  Fly   421 KHKKR 425
            :|..|
  Fly   275 RHLSR 279

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2678	NP_649750.1	zf-AD	8..85	CDD:214871	20/51 (39%)
		COG5048	220..>284	CDD:227381	24/63 (38%)
		C2H2 Zn finger	223..243	CDD:275368	10/19 (53%)
		zf-C2H2	249..271	CDD:278523	7/21 (33%)
		C2H2 Zn finger	251..271	CDD:275368	7/19 (37%)
		C2H2 Zn finger	279..299	CDD:275368	6/19 (32%)
		C2H2 Zn finger	350..370	CDD:275368	8/19 (42%)
		C2H2 Zn finger	379..399	CDD:275368	8/19 (42%)
		C2H2 Zn finger	406..427	CDD:275368	8/20 (40%)
Neu2	NP_649316.1	zf-AD	1..63	CDD:285071	21/53 (40%)
		COG5048	<119..241	CDD:227381	45/190 (24%)
		C2H2 Zn finger	121..141	CDD:275368	10/19 (53%)
		zf-H2C2_2	133..158	CDD:290200	10/24 (42%)
		C2H2 Zn finger	149..169	CDD:275368	7/19 (37%)
		zf-H2C2_2	162..185	CDD:290200	9/22 (41%)
		C2H2 Zn finger	177..197	CDD:275368	6/19 (32%)
		C2H2 Zn finger	205..225	CDD:275368	8/19 (42%)
		zf-C2H2_8	206..286	CDD:292531	29/75 (39%)
		C2H2 Zn finger	233..253	CDD:275368	8/19 (42%)
		C2H2 Zn finger	260..297	CDD:275368	8/20 (40%)
		C2H2 Zn finger	303..323	CDD:275368
		C2H2 Zn finger	353..373	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24409
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010