DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2678 and CG10543

DIOPT Version :9

Sequence 1:	NP_649750.1	Gene:	CG2678 / 40937	FlyBaseID:	FBgn0014931	Length:	434	Species:	Drosophila melanogaster
Sequence 2:	NP_001369100.1	Gene:	CG10543 / 37379	FlyBaseID:	FBgn0034570	Length:	1666	Species:	Drosophila melanogaster

Alignment Length:	416	Identity:	89/416 - (21%)
Similarity:	137/416 - (32%)	Gaps:	129/416 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 QHFFRVLNQSGAPENQVHLAACN--GDKNQIINQKMQLKSDRQQDTQQMTKTQKPDD---DLSQK 142
            ||...::|....|.    |||.:  ||...:..   ||.|..:.|...::..:..||   ||.:.
  Fly   622 QHGASMMNSRQMPA----LAALSNLGDTPAMSG---QLNSSLELDDNDLSADEDDDDLDHDLDEL 679

  Fly   143 QTLQAKLQEG------NIDGPPESFTLH-----------PRKRTCRTEEQADMIPKEATRSTKMI 190
            ...:.:|.:|      ::..||..   |           |..:..:......:.|| :.|..|.:
  Fly   680 DAAKQQLIDGGSSSSTSLQAPPSQ---HGSGSGGSGGQTPGSKKDKPSYNCLLCPK-SYRKRKSL 740

  Fly   191 CD----ADGYYNCPHCSKRFCSQTQ-----LRT-HITDLCNRCPYCPRTYMQKSNLKRH------ 239
            .|    ..||  |..|.:|..:..:     .|| |:.:....|..|..:|.:|.....|
  Fly   741 LDHYKMHPGY--CHDCGQRNGNTLEEIIHHNRTMHVKEFPFVCETCGESYSRKQQFHAHVESHNK 803

  Fly   240 -------------------LRNHLSKPAHK-----CFHCSKAFMRKDHLKRH-LRTHDSDGPLSC 279
                               |:.|..:..||     |..|.:.|..|:.|.:| :|.|..|....|
  Fly   804 KEIKTFPCGECGLKFPQKKLQQHFEETGHKADGAICEVCGEEFQSKNALYQHIIRVHKRDNFFEC 868

  Fly   280 SQCSAVFIEHVQLEIHRREHKQRPGSSKSESTKDPDSDDSDQAQDLKPKWTKNTFNGTCSIPPML 344
            ..|...|.....||.|.:.|.:                                          :
  Fly   869 HICHNRFTLKANLERHVQLHTE------------------------------------------I 891

  Fly   345 KPKPICDICQKKFSSVYALKRHMLTHNRQHHLKKCTYCSEEFKTEKHLKRH------ERGHMGDL 403
            |...:||:|...:.:..|||.|....:......|||.|.:.|.:.|.|:||      ||.|.
  Fly   892 KRPYVCDLCGSSYFTYPALKEHYSNAHVDVSECKCTLCGKRFGSAKSLQRHLPSHSEERPHC--- 953

  Fly   404 FRCEFCSLVFVDVNYLRKHKKRIHSN 429
              |.:|...|....:|.:||:.:|.|
  Fly   954 --CNYCDQTFKWKTHLVRHKQTMHGN 977

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2678	NP_649750.1	zf-AD	8..85	CDD:214871	1/1 (100%)
		COG5048	220..>284	CDD:227381	20/94 (21%)
		C2H2 Zn finger	223..243	CDD:275368	6/44 (14%)
		zf-C2H2	249..271	CDD:278523	9/27 (33%)
		C2H2 Zn finger	251..271	CDD:275368	7/20 (35%)
		C2H2 Zn finger	279..299	CDD:275368	6/19 (32%)
		C2H2 Zn finger	350..370	CDD:275368	7/19 (37%)
		C2H2 Zn finger	379..399	CDD:275368	10/25 (40%)
		C2H2 Zn finger	406..427	CDD:275368	6/20 (30%)
CG10543	NP_001369100.1	C2H2 Zn finger	727..747	CDD:275368	5/20 (25%)
		C2H2 Zn finger	751..773	CDD:275368	5/21 (24%)
		C2H2 Zn finger	781..801	CDD:275368	5/19 (26%)
		PHA00733	<804..860	CDD:177301	11/55 (20%)
		C2H2 Zn finger	811..827	CDD:275368	1/15 (7%)
		C2H2 Zn finger	839..860	CDD:275368	7/20 (35%)
		C2H2 Zn finger	868..888	CDD:275368	6/19 (32%)
		C2H2 Zn finger	897..913	CDD:275368	6/15 (40%)
		C2H2 Zn finger	926..946	CDD:275368	8/19 (42%)
		C2H2 Zn finger	954..975	CDD:275368	6/20 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24409
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100