DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG2678 and ZKSCAN2

DIOPT Version :9

Sequence 1:NP_649750.1 Gene:CG2678 / 40937 FlyBaseID:FBgn0014931 Length:434 Species:Drosophila melanogaster
Sequence 2:NP_001012999.3 Gene:ZKSCAN2 / 342357 HGNCID:25677 Length:967 Species:Homo sapiens


Alignment Length:504 Identity:98/504 - (19%)
Similarity:155/504 - (30%) Gaps:159/504 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 DETGTLVDIFANVRDPVLDEPEMSLSHILARCTERPVKRGDLLPQFICVSC-VLAVQNAFRFKWQ 77
            :||.|.:||....|          ....|..|..:....|.:..|.  ..| .|......|.|::
Human   503 EETKTFLDILRETR----------FYEALQACHRKSKLYGAVAEQL--RECGFLRTPEQCRTKFK 555

  Fly    78 S-EQSYQHFFRVLNQSGAPENQVHLAACNGDKNQIINQKMQLKS----------DRQQDTQQMTK 131
            | ::||:   :|.|     .:.:...|...:.:.:||.:....|          .||:......:
Human   556 SLQKSYR---KVKN-----GHVLESCAFYKEMDALINSRASAPSPSTPEEVPSPSRQERGGIEVE 612

  Fly   132 TQKP--------------DDDLSQKQTLQAKLQEGNIDGPP------------ESFTLHPRKRTC 170
            .|:|              :|..|::.:.:..:||....|||            .|....|.:...
Human   613 PQEPTGWEPEETSQEAVIEDSCSERMSEEEIVQEPEFQGPPGLLQSPNDFEIGSSIKEDPTQIVY 677

  Fly   171 RTEEQADMIPKEATRSTKMICDADGY----------------------------------YNCPH 201
            :..||...:.:::.|......|...|                                  :..|.
Human   678 KDMEQHRALIEKSKRVVSQSTDPSKYRKRECISGRQWENLQGIRQGKPMSQPRDLGKAVVHQRPF 742

  Fly   202 CSKR----------FCSQTQL---RTHITDLCNRCPYCPRTYMQKSNLKRHLRNHLSKPAHKCFH 253
            ..||          |...|:|   .||..:...:|..|.:.:.:..:|.||.|.|..:...||..
Human   743 VGKRPYRLLKYGESFGRSTRLMCRMTHHKENPYKCGVCGKCFGRSRSLIRHQRIHTGEKPFKCLD 807

  Fly   254 CSKAFMRKDHLKRHLRTHDSDGPLSCSQCSAVFIEHVQLEIHRREHKQRPGSSKSESTKDPDSDD 318
            |.|:|....:...|.|.|..:.|..|.:|...|.:...|.||:|.|...                
Human   808 CGKSFNDSSNFGAHQRIHTGEKPYRCGECGKCFSQSSSLIIHQRTHTGE---------------- 856

  Fly   319 SDQAQDLKPKWTKNTFNGTCSIPPMLKPKPI-CDICQKKFSSVYALKRHMLTHNRQH---HLKKC 379
                                        ||. |..|.|.|::    ..|...|.|.|   :..||
Human   857 ----------------------------KPYQCGECGKSFTN----SSHFSAHRRVHTGENPYKC 889

  Fly   380 TYCSEEFKTEKHLKRHERGHMGDL-FRCEFCSLVFVDVNYLRKHKKRIH 427
            ..|.:.|......:.|.|.|.|:. :.|..|...|...:.|.||:: :|
Human   890 VDCEKSFNNCTRFREHRRIHTGEKPYGCAQCGKRFSKSSVLTKHRE-VH 937

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG2678NP_649750.1 zf-AD 8..85 CDD:214871 17/72 (24%)
COG5048 220..>284 CDD:227381 18/63 (29%)
C2H2 Zn finger 223..243 CDD:275368 6/19 (32%)
zf-C2H2 249..271 CDD:278523 7/21 (33%)
C2H2 Zn finger 251..271 CDD:275368 6/19 (32%)
C2H2 Zn finger 279..299 CDD:275368 7/19 (37%)
C2H2 Zn finger 350..370 CDD:275368 5/19 (26%)
C2H2 Zn finger 379..399 CDD:275368 5/19 (26%)
C2H2 Zn finger 406..427 CDD:275368 6/20 (30%)
ZKSCAN2NP_001012999.3 SCAN 41..148 CDD:128708
SCAN 41..129 CDD:280241
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 150..205
KRAB_A-box 227..268 CDD:143639
KRAB <248..289 CDD:214630
Myb_DNA-bind_4 340..421 CDD:290549
Myb_DNA-bind_4 497..578 CDD:290549 20/94 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 586..626 5/39 (13%)
COG5048 771..>957 CDD:227381 49/216 (23%)
zf-C2H2 775..797 CDD:278523 6/21 (29%)
C2H2 Zn finger 777..797 CDD:275368 6/19 (32%)
zf-H2C2_2 789..813 CDD:290200 9/23 (39%)
zf-C2H2 803..825 CDD:278523 7/21 (33%)
C2H2 Zn finger 805..825 CDD:275368 6/19 (32%)
zf-C2H2 831..853 CDD:278523 7/21 (33%)
C2H2 Zn finger 833..853 CDD:275368 7/19 (37%)
zf-H2C2_2 845..870 CDD:290200 11/68 (16%)
C2H2 Zn finger 861..881 CDD:275368 7/23 (30%)
zf-H2C2_2 873..898 CDD:290200 8/24 (33%)
C2H2 Zn finger 889..909 CDD:275368 5/19 (26%)
zf-H2C2_2 902..925 CDD:290200 6/22 (27%)
C2H2 Zn finger 917..937 CDD:275368 6/20 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 941..967
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
00.000

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