DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2678 and CG4496

DIOPT Version :9

Sequence 1:	NP_649750.1	Gene:	CG2678 / 40937	FlyBaseID:	FBgn0014931	Length:	434	Species:	Drosophila melanogaster
Sequence 2:	NP_001285707.1	Gene:	CG4496 / 34000	FlyBaseID:	FBgn0031894	Length:	580	Species:	Drosophila melanogaster

Alignment Length:	372	Identity:	79/372 - (21%)
Similarity:	132/372 - (35%)	Gaps:	116/372 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 HILARCTERPV-------------------KRGDLLPQFICVSCVLAVQNAFRFKWQSEQSYQHF 85
            |::....|||.                   :|....|||||:.|.|
  Fly   263 HMMIHTGERPFPCDLCERRFREFSDLKKHRRRHSHDPQFICMICHL------------------- 308

  Fly    86 FRVLNQSGAP--ENQVHLAACNGDKNQIINQKMQLKSDRQQDTQQMTKTQKPDDDLSQKQTLQAK 148
                   |||  ::....|.|. .||.::  |.|.:...::.|::.:...:.|||..::..|:.:
  Fly   309 -------GAPLEQDSTRCADCE-SKNLMV--KPQPEELGEKTTEEHSDEMEGDDDEIEEAALENE 363

  Fly   149 LQE-------------GNIDGPPESFTLH------PRKRTCRTEEQADMIPKEATRSTKMICDAD 194
            .|.             ..|..|||....|      |..|:|.:...:..:..:...:.|.:
  Fly   364 KQPQVATQPSLMVTLIPPIQSPPEKVPSHTQPSRPPLPRSCSSANSSSSLSNDGNIAGKSM---- 424

  Fly   195 GYYNCPHCSKRFCSQTQLRTHITDLCNRCPYCPRTYMQKSNLKRHLRNHLSKPAHKCFHCSKAFM 259
                         |:|: |::      .||.|.|.:..:.|||||...|..:....|..|.|.|.
  Fly   425 -------------SRTR-RSY------PCPLCHRPFGTRHNLKRHYMIHTGEKPFSCSKCRKPFR 469

  Fly   260 RKDHLKRHLRTHDSDGPLSCSQCSAVFIEHVQLEIHRREHKQRPGSSKSESTKDPDSDDSDQAQD 324
            ....||:|:.||..|....|.:|.:.|.::::...|:..|:.:..|.||...:..|..||
  Fly   470 ECSTLKKHMVTHVRDRWYKCLRCPSKFRDYLEYSDHKNNHQDQLSSRKSSIYESDDDGDS----- 529

  Fly   325 LKPKWTKNTFNGTCSIPPMLKPKPICDICQKKFSSVYALKRHMLTHN 371
                          |:...|:    |..||::|:.:.|...|:..|:
  Fly   530 --------------SVEDCLE----CCECQQRFTELDAYTAHLKKHD 558

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2678	NP_649750.1	zf-AD	8..85	CDD:214871	12/63 (19%)
		COG5048	220..>284	CDD:227381	22/63 (35%)
		C2H2 Zn finger	223..243	CDD:275368	9/19 (47%)
		zf-C2H2	249..271	CDD:278523	7/21 (33%)
		C2H2 Zn finger	251..271	CDD:275368	7/19 (37%)
		C2H2 Zn finger	279..299	CDD:275368	4/19 (21%)
		C2H2 Zn finger	350..370	CDD:275368	6/19 (32%)
		C2H2 Zn finger	379..399	CDD:275368
		C2H2 Zn finger	406..427	CDD:275368
CG4496	NP_001285707.1	zf-C2H2	245..267	CDD:278523	1/3 (33%)
		C2H2 Zn finger	247..267	CDD:275368	1/3 (33%)
		zf-H2C2_2	259..282	CDD:290200	4/18 (22%)
		C2H2 Zn finger	275..295	CDD:275368	0/19 (0%)
		zf-C2H2	431..453	CDD:278523	9/27 (33%)
		C2H2 Zn finger	433..453	CDD:275368	9/19 (47%)
		zf-H2C2_2	445..468	CDD:290200	9/22 (41%)
		C2H2 Zn finger	461..481	CDD:275368	7/19 (37%)
		C2H2 Zn finger	489..510	CDD:275368	4/20 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24409
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100