DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2678 and CG2202

DIOPT Version :9

Sequence 1:	NP_649750.1	Gene:	CG2678 / 40937	FlyBaseID:	FBgn0014931	Length:	434	Species:	Drosophila melanogaster
Sequence 2:	NP_572657.2	Gene:	CG2202 / 32014	FlyBaseID:	FBgn0030240	Length:	889	Species:	Drosophila melanogaster

Alignment Length:	649	Identity:	142/649 - (21%)
Similarity:	208/649 - (32%)	Gaps:	271/649 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 AKNVCRTCMDET---GTLVDIFANVRDPVLDEPEMSLSHILARCTERPVKRGDLLPQFICVSCVL 66
            |:.|||.|:.:.   |.|..||...  ||  |.:.:|:.||..||....:|.|.:|..:|.|||.
  Fly    42 AERVCRVCLKDVSLEGELHFIFNET--PV--EQDANLARILDECTLHQCERNDGMPPHMCSSCVE 102

  Fly    67 AVQNAFRFKWQSEQSYQHFFRVLNQS----------GAPENQVHLAACNGDKNQIINQKMQLKSD 121
            |.:||:|||..:|:||.....:|.:|          .:..:||.|..|....:|.:| .::|:..
  Fly   103 AARNAYRFKRHAERSYCSLVALLGRSPQLKARGAEAASQTDQVALLPCEMCHDQFLN-SLELRLH 166

  Fly   122 RQQ---DTQQMTKTQK---PDDDL---------------------SQKQTLQAKLQ--------- 150
            |.|   .|::.|....   |.:|.                     |.:||  |:||
  Fly   167 RNQVHRTTKEATSAGTDGLPSEDFKCKFCPQHFPHLRQLRSHLARSHEQT--ARLQCAHCQRTFS 229

  Fly   151 -------------------------------------------------EGNID----------- 155
                                                             |.|.|
  Fly   230 RRDHLLRHIRNQHRDVEEDLLRTWPPADENTMNSDGGDELVSAEVLLNEEDNEDEVVGEAFQCNT 294

  Fly   156 --------------GPPESFTLHPRKRTCRTEEQADM-----IPKEATRSTKM------------ 189
                          |..::..||.:...|...|:.|:     :.|:..|..|.
  Fly   295 NPISSNEDDGEEANGANQTLWLHIKPEPCLEAEEVDLAMQLKLEKKRRRREKAEAQAETSIDRTV 359

  Fly   190 ----ICDADGYYNCPHCSKRFCSQTQ--------LRTHI-------------------TDL---- 219
                |...|..::....::...|..:        ::.|:                   :||
  Fly   360 KNEHIAIGDSQFSIKEENQLVGSDDEAPMGVEDFMKLHVSGELPLSDEERFDGFADDDSDLDDDD 424

  Fly   220 ------------------------------------------------CNRCPYCPRTYMQKSNL 236
                                                            .|||..|.||:.:..:|
  Fly   425 DDDDEEDAGDDDDGEFRLKQEPLDGEKPLKKAKSGRRRRRRNKDEPNPDNRCEVCQRTFSRHCHL 489

  Fly   237 KRHLRNHLSKPAHKCFHCSKAFMRKDHLKRHLRTHDSDGPLSCSQCSAVFIEHVQLEIHR-REHK 300
            .||..:||.|..|.|.||.|||.|.||||.|:::..|:....||.|.|.|.....||.|: .:|.
  Fly   490 LRHKLSHLEKKPHNCPHCPKAFARSDHLKAHVQSLHSNKEHKCSLCEAAFSRLDALERHKVSKHN 554

  Fly   301 ---QRPGSSKSESTKDPDSDDSDQAQDLKPKWTKNTFNGTCSIPPMLKPKPICDICQKKFSSVYA 362
               ..|||                  :||.:..::|                |:.|.|:|||...
  Fly   555 GEGLEPGS------------------ELKLQLAEHT----------------CEYCSKRFSSKTY 585

  Fly   363 LKRHMLTHNRQHHLKKCTYCSEEFKTEKHLKRHERGHMGDL-FRCEFCSLVFVDVNYLRKHKKR 425
            |::|.|.|.  ..|..|..|.|.|:....|:.||:.|.|.. |.|..|...|...:|||.|.:|
  Fly   586 LRKHTLLHT--DFLYACKTCDETFRERAQLREHEKTHTGQRNFLCCICGDSFARNDYLRVHMRR 647

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2678	NP_649750.1	zf-AD	8..85	CDD:214871	32/79 (41%)
		COG5048	220..>284	CDD:227381	29/63 (46%)
		C2H2 Zn finger	223..243	CDD:275368	7/19 (37%)
		zf-C2H2	249..271	CDD:278523	13/21 (62%)
		C2H2 Zn finger	251..271	CDD:275368	12/19 (63%)
		C2H2 Zn finger	279..299	CDD:275368	8/20 (40%)
		C2H2 Zn finger	350..370	CDD:275368	9/19 (47%)
		C2H2 Zn finger	379..399	CDD:275368	7/19 (37%)
		C2H2 Zn finger	406..427	CDD:275368	8/20 (40%)
CG2202	NP_572657.2	zf-AD	45..121	CDD:285071	32/79 (41%)
		C2H2 Zn finger	150..171	CDD:275368	6/21 (29%)
		C2H2 Zn finger	192..213	CDD:275370	0/20 (0%)
		C2H2 Zn finger	221..239	CDD:275370	0/17 (0%)
		COG5048	<443..730	CDD:227381	70/241 (29%)
		C2H2 Zn finger	476..496	CDD:275368	7/19 (37%)
		zf-H2C2_2	488..513	CDD:290200	13/24 (54%)
		C2H2 Zn finger	504..525	CDD:275368	12/20 (60%)
		C2H2 Zn finger	532..548	CDD:275368	7/15 (47%)
		C2H2 Zn finger	573..593	CDD:275368	9/19 (47%)
		C2H2 Zn finger	600..620	CDD:275368	7/19 (37%)
		zf-H2C2_2	613..637	CDD:290200	9/23 (39%)
		C2H2 Zn finger	628..648	CDD:275368	8/20 (40%)
		zf-H2C2_2	640..663	CDD:290200	5/8 (63%)
		C2H2 Zn finger	656..676	CDD:275368
		C2H2 Zn finger	684..704	CDD:275368
		zf-C2H2	684..704	CDD:278523
		zf-H2C2_2	696..721	CDD:290200
		C2H2 Zn finger	712..732	CDD:275368
		C2H2 Zn finger	739..755	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006715
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.000