DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2678 and Zfp189

DIOPT Version :9

Sequence 1:	NP_649750.1	Gene:	CG2678 / 40937	FlyBaseID:	FBgn0014931	Length:	434	Species:	Drosophila melanogaster
Sequence 2:	NP_001101400.1	Gene:	Zfp189 / 313219	RGDID:	1306510	Length:	608	Species:	Rattus norvegicus

Alignment Length:	484	Identity:	106/484 - (21%)
Similarity:	169/484 - (34%)	Gaps:	167/484 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 NGDKNQIINQKMQ------------LKSDRQQDTQ---------QMTKT------QKPDDDLSQK 142
            |.|:...:.::::            :||:..||..         ::.|.      :.|.|.|:::
  Rat    45 NEDEEPTVKEEIEKDIEPQGIIVTRIKSELDQDPMGSETFELVGRLDKQRGIFLWEIPRDSLTEE 109

  Fly   143 QTLQAKLQEG--NIDGPPES-------------------FTLHPRKRTCRTEEQADMIPKEATRS 186
            |    |:..|  |:...|.|                   |..|.|..|.....|.:...|..:||
  Rat   110 Q----KMFRGHTNVRKRPNSEEKCHKCEECGKRFVRKAHFIQHQRVHTGEKPFQCNECGKSFSRS 170

  Fly   187 T-----KMICDADGYYNCPHCSKRFCSQTQL----RTHITDLCNRCPYCPRTYMQKSNLKRHLRN 242
            :     :.|...:..|.|.:|.|.|...:.|    |.|..:...:|..|.:::.|:.:|.:|.|.
  Rat   171 SFVIEHQRIHTGERPYECNYCGKTFSVSSTLIRHQRIHTGERPYQCNQCKQSFSQRRSLVKHQRI 235

  Fly   243 HLSKPAHKCFHCSKAFMRKDHLKRHLRTHDSDGPLSCSQC------SAVFIEHVQLEIHRREHK- 300
            |..:..|||..|.|||..|.||..|.|||..:.|..|::|      :::.:||.::....|.||
  Rat   236 HTGEKPHKCSDCGKAFSWKSHLIEHQRTHTGEKPYHCTKCKKSFSRNSLLVEHQRIHTGERPHKC 300

  Fly   301 ----------------------QRP------GSSKSEST------KDPDSDDSDQAQDL------ 325
                                  ::|      |.|.|.|:      :....:...|.|:.
  Rat   301 GECGKAFRLSTYLIQHQKIHTGEKPFLCIECGKSFSRSSFLIEHQRIHTGERPYQCQECGKSFSQ 365

  Fly   326 --------------KP-------------------------------KWTKNTFNGTCS--IPPM 343
                          ||                               |.||.:|:..|.  |...
  Rat   366 LCNLTRHQRIHTGDKPHKCEECGKAFSRSSGLIQHQRIHIREKTSPFKETKGSFDPNCGLVIQQE 430

  Fly   344 LKPKP---ICDICQKKFSSVYALKRHMLTHNRQHHLKK---CTYCSEEFKTEKHLKRHERGHMGD 402
            :.||.   .||.|.|.||    :..|::.|.|.|..:|   ||.|.:.|.....|..|:|.|.|:
  Rat   431 VYPKEKSYKCDDCGKTFS----VSAHLVQHQRIHTGEKPYLCTVCGKSFSRSSFLIEHQRIHTGE 491

  Fly   403 L-FRCEFCSLVFVDVNYLRKHKKRIHSNN 430
            . :.|..|...|..:..|.:| :.:|:.|
  Rat   492 RPYLCRQCGKSFSQLCNLIRH-QGVHTGN 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2678	NP_649750.1	zf-AD	8..85	CDD:214871
		COG5048	220..>284	CDD:227381	24/69 (35%)
		C2H2 Zn finger	223..243	CDD:275368	6/19 (32%)
		zf-C2H2	249..271	CDD:278523	12/21 (57%)
		C2H2 Zn finger	251..271	CDD:275368	10/19 (53%)
		C2H2 Zn finger	279..299	CDD:275368	5/25 (20%)
		C2H2 Zn finger	350..370	CDD:275368	7/19 (37%)
		C2H2 Zn finger	379..399	CDD:275368	7/19 (37%)
		C2H2 Zn finger	406..427	CDD:275368	5/20 (25%)
Zfp189	NP_001101400.1	KRAB_A-box	<10..39	CDD:143639
		COG5048	116..506	CDD:227381	89/393 (23%)
		C2H2 Zn finger	132..152	CDD:275368	3/19 (16%)
		zf-H2C2_2	144..169	CDD:290200	6/24 (25%)
		C2H2 Zn finger	160..180	CDD:275368	3/19 (16%)
		zf-H2C2_2	175..196	CDD:290200	5/20 (25%)
		C2H2 Zn finger	188..208	CDD:275368	6/19 (32%)
		zf-H2C2_2	201..225	CDD:290200	5/23 (22%)
		C2H2 Zn finger	216..236	CDD:275368	6/19 (32%)
		zf-H2C2_2	228..252	CDD:290200	10/23 (43%)
		C2H2 Zn finger	244..264	CDD:275368	10/19 (53%)
		zf-H2C2_2	256..281	CDD:290200	9/24 (38%)
		C2H2 Zn finger	272..292	CDD:275368	4/19 (21%)
		zf-H2C2_2	285..307	CDD:290200	5/21 (24%)
		C2H2 Zn finger	300..320	CDD:275368	0/19 (0%)
		zf-H2C2_2	312..337	CDD:290200	3/24 (13%)
		C2H2 Zn finger	328..348	CDD:275368	4/19 (21%)
		zf-H2C2_2	341..365	CDD:290200	2/23 (9%)
		C2H2 Zn finger	356..376	CDD:275368	1/19 (5%)
		zf-H2C2_2	368..393	CDD:290200	2/24 (8%)
		C2H2 Zn finger	384..404	CDD:275368	0/19 (0%)
		C2H2 Zn finger	440..460	CDD:275368	9/23 (39%)
		zf-H2C2_2	452..477	CDD:290200	9/24 (38%)
		C2H2 Zn finger	468..488	CDD:275368	7/19 (37%)
		zf-H2C2_2	481..505	CDD:290200	8/23 (35%)
		C2H2 Zn finger	496..516	CDD:275368	5/20 (25%)
		zf-H2C2_2	508..533	CDD:290200	4/13 (31%)
		C2H2 Zn finger	524..544	CDD:275368
		zf-H2C2_2	537..561	CDD:290200
		C2H2 Zn finger	552..572	CDD:275368
		C2H2 Zn finger	583..603	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000